Non-Cochrane · prognostic · PM42092891
Survival rate and risk factors of implants in patients with head and neck neoplasms: a systematic review and meta-analysis.
Liu Yingman, Yang Chunhao, Song Yafan, et al. · BMC oral health · 2026 · PubMed · doi:10.1186/s12903-026-08304-8
Findings
Population Patients with head and neck neoplasms who received dental implants
18 findings
| Dental implant therapy | None | Implant survival Follow-up 3-5 years · Follow-up 3-5 years | Pooled proportion 0.85 [0.81, 0.90] GRADE not reported 20 studies |
| Dental implant therapy | None | Implant survival Follow-up >5 years · Follow-up >5 years | Pooled proportion 0.89 [0.83, 0.95] GRADE not reported 8 studies |
| Dental implant therapy | None | Implant survival Longest available follow-up (minimum 12 months) | Pooled proportion 0.88 [0.85, 0.90] GRADE not reported 42 studies · 2448 participants |
| Dental implant therapy | None | Implant survival Follow-up 1-3 years · Follow-up 1-3 years | Pooled proportion 0.90 [0.86, 0.94] GRADE not reported 14 studies |
| Female sex | Male sex | Implant survival | RR 0.98 [0.93, 1.03] GRADE not reported 6 studies |
| Smoking | No smoking | Implant survival Longest available follow-up (minimum 12 months) | RR 1.04 [0.94, 1.15] GRADE not reported 9 studies |
| T1-T2 tumor stage | T3-T4 tumor stage | Implant survival Longest available follow-up (minimum 12 months) | RR 1.03 [0.96, 1.11] GRADE not reported 3 studies |
| Radiotherapy (irradiated bone) | No radiotherapy (non-irradiated bone) | Implant survival Longest available follow-up (minimum 12 months) | RR 0.95 [0.91, 0.99] GRADE not reported 18 studies |
| Irradiation dose 50 Gy or less | Irradiation dose above 50 Gy | Implant survival Longest available follow-up (minimum 12 months) | RR 1.08 [0.98, 1.20] GRADE not reported 8 studies |
| Hyperbaric oxygen therapy (HBO) | No HBO | Implant survival Longest available follow-up (minimum 12 months) | RR 1.47 [1.06, 2.03] GRADE not reported 5 studies |
| Chemotherapy | No chemotherapy | Implant survival Longest available follow-up (minimum 12 months) | RR 0.99 [0.93, 1.04] GRADE not reported 7 studies |
| Grafted bone | Native bone | Implant survival Longest available follow-up (minimum 12 months) | RR 0.92 [0.88, 0.97] GRADE not reported 15 studies |
| Fibula flap | Iliac flap | Implant survival Longest available follow-up (minimum 12 months) | RR 0.97 [0.92, 1.03] GRADE not reported 6 studies |
| Grafted soft tissue | No grafted soft tissue | Implant survival Longest available follow-up (minimum 12 months) | RR 0.94 [0.87, 1.02] GRADE not reported 3 studies |
| Maxilla implant site | Mandible implant site | Implant survival Longest available follow-up (minimum 12 months) | RR 1.00 [0.99, 1.02] GRADE not reported 16 studies |
| Anterior implant site | Posterior implant site | Implant survival Longest available follow-up (minimum 12 months) | RR 1.07 [1.02, 1.12] GRADE not reported 6 studies |
| Immediate implant placement | Delayed implant placement | Implant survival Longest available follow-up (minimum 12 months) | RR 0.97 [0.86, 1.10] GRADE not reported 4 studies |
| Fixed prosthesis | Removable prosthesis | Implant survival Longest available follow-up (minimum 12 months) | RR 0.90 [0.76, 1.06] GRADE not reported 3 studies |
Included primary studies 76
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Buddula 2011 Survival of dental implants in native and grafted bone in irradiated head and neck cancer patients: a retrospective analysis. PMID:22406706 | 2011 | 1 other review | not stated | not extracted yet |
| Laverty 2019 Outcomes of implant-based oral rehabilitation in head and neck oncology patients-a retrospective evaluation of a large, single regional… PMID:30834461 | 2019 | 1 other review | not stated | not extracted yet |
| Lee 2022 Risk factor analysis of dental implants in patients with irradiated head and neck cancer. PMID:35546491 | 2022 | 1 other review | not stated | not extracted yet |
| Mancha de la Plata 2012 Osseointegrated implant rehabilitation of irradiated oral cancer patients. PMID:21778009 | 2012 | 1 other review | not stated | not extracted yet |
| Pompa 2015 Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study. PMID:25599761 | 2015 | 1 other review | not stated | not extracted yet |
| Rana 2016 Assessment of the Survival of Dental Implants in Irradiated Jaws Following Treatment of Oral Cancer: A Retrospective Study. PMID:27843270 | 2016 | 1 other review | not stated | not extracted yet |
| Schiegnitz 2021 Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients. PMID:34255187 | 2021 | 1 other review | not stated | not extracted yet |
| Schweyen 2022 Factors Influencing the Survival Rate of Teeth and Implants in Patients after Tumor Therapy to the Head and Neck Region-Part 2: Implant… PMID:36362546 | 2022 | 1 other review | not stated | not extracted yet |
| Shaw 2005 Oral rehabilitation after treatment for head and neck malignancy. PMID:15880417 | 2005 | 1 other review | not stated | not extracted yet |
| Visch 2002 A clinical evaluation of implants in irradiated oral cancer patients. PMID:12454102 | 2002 | 1 other review | not stated | not extracted yet |
| Buddula 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Burgess 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Burgess 2016 Osseointegrated implants into a variety of composite free flaps: A comparative analysis. PMID:27880030 | 2017 | this review only | not stated | not extracted yet |
| Cao 2003 Comparison of maxillary implant-supported prosthesis in irradiated and non-irradiated patients. PMID:12973954 | 2003 | this review only | not stated | not extracted yet |
| Cuesta-Gil 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Cuesta-Gil 2009 Oral rehabilitation with osseointegrated implants in oncologic patients. PMID:19837322 | 2009 | this review only | not stated | not extracted yet |
| Dholam 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Dholam 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Dholam 2013 Implant-retained dental rehabilitation in head and neck cancer patients: an assessment of success and failure. PMID:24149001 | 2013 | this review only | not stated | not extracted yet |
| Ernst 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ernst 2016 Changes in Peri-Implant Bone Level and Effect of Potential Influential Factors on Dental Implants in Irradiated and Nonirradiated Patients… PMID:27376183 | 2016 | this review only | not stated | not extracted yet |
| Fenlon 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Fenlon 2009 Factors affecting survival and usefulness of implants placed in vascularized free composite grafts used in post-head and neck cancer… PMID:19843102 | 2012 | this review only | not stated | not extracted yet |
| Goker 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Goker 2022 Oral rehabilitation of oncology patients with dental implants after reconstruction surgery with autogenous flaps. PMID:36591879 | 2022 | this review only | not stated | not extracted yet |
| Granstrom 1999 Osseointegrated implants in irradiated bone: a case-controlled study using adjunctive hyperbaric oxygen therapy. PMID:10319821 | 1999 | this review only | not stated | not extracted yet |
| Granström 1999 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Heberer 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Heberer 2011 Rehabilitation of irradiated patients with modified and conventional sandblasted acid-etched implants: preliminary results of a… PMID:21121960 | 2011 | this review only | not stated | not extracted yet |
| Hessling 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hessling 2015 Implant-based rehabilitation in oncology patients can be performed with high long-term success. PMID:25773649 | 2015 | this review only | not stated | not extracted yet |
| Huang 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Huang 2012 Long-term results for maxillary rehabilitation with dental implants after tumor resection. PMID:22882292 | 2014 | this review only | not stated | not extracted yet |
| Katsoulis 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Katsoulis 2013 Prosthetic rehabilitation, implant survival and quality of life 2 to 5 years after resection of oral tumors. PMID:21435159 | 2013 | this review only | not stated | not extracted yet |
| Khadembaschi 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khadembaschi 2021 Outcomes of osseointegrated implants in patients with benign and malignant pathologies of the head and neck: a 10-year single-centre study. PMID:33642153 | 2021 | this review only | not stated | not extracted yet |
| Klein 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Klein 2009 Functional rehabilitation of mandibular continuity defects using autologous bone and dental implants - prognostic value of bone origin,… PMID:19628944 | 2009 | this review only | not stated | not extracted yet |
| Korfage 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Korfage 2010 Five-year follow-up of oral functioning and quality of life in patients with oral cancer with implant-retained mandibular overdentures. PMID:21560179 | 2011 | this review only | not stated | not extracted yet |
| Kovacs 2001 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kovács 2001 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Landes 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Landes 2006 Comparison of early telescope loading of non-submerged ITI implants in irradiated and non-irradiated oral cancer patients. PMID:16907766 | 2006 | this review only | not stated | not extracted yet |
| Laverty 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Linsen 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Linsen 2012 Long-term results of endosteal implants following radical oral cancer surgery with and without adjuvant radiation therapy. PMID:19843104 | 2012 | this review only | not stated | not extracted yet |
| Lodders 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lodders 2021 Long-term outcomes of implant-based dental rehabilitation in head and neck cancer patients after reconstruction with the free vascularized… PMID:33985871 | 2021 | this review only | not stated | not extracted yet |
| Mancha de la Plata 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mattila 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mattila 2024 Survival of dental implants and occurrence of mucosal overgrowth in patients with head and neck cancer treated with/without radiotherapy… PMID:38273180 | 2024 | this review only | not stated | not extracted yet |
| Nack 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pompa 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Rana 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sammartino 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sammartino 2011 Implant therapy in irradiated patients. PMID:21403560 | 2011 | this review only | not stated | not extracted yet |
| Schepers 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Schepers 2006 Effect of postoperative radiotherapy on the functional result of implants placed during ablative surgery for oral cancer. PMID:16697146 | 2006 | this review only | not stated | not extracted yet |
| Schiegnitz 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Schweyen 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Shaw 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Visch 2002 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wagner 1998 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Weischer 1999 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Weischer 1999 Ten-year experience in oral implant rehabilitation of cancer patients: treatment concept and proposed criteria for success. PMID:10453667 | 1999 | this review only | not stated | not extracted yet |
| Weischer 2001 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Werkmeister 1999 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Werkmeister 1999 Rehabilitation with dental implants of oral cancer patients. PMID:10188126 | 1999 | this review only | not stated | not extracted yet |
| Wolf 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wolf 2021 Significance of site-specific radiation dose and technique for success of implant-based prosthetic rehabilitation in irradiated head and… PMID:33949108 | 2021 | this review only | not stated | not extracted yet |
| Woods 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Woods 2019 A Comparison of Immediate and Delayed Dental Implant Placement in Head and Neck Surgery Patients. PMID:30851250 | 2019 | this review only | not stated | not extracted yet |
| Yerit 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yerit 2006 Implant survival in mandibles of irradiated oral cancer patients. PMID:16672031 | 2006 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with benign or malignant head and neck neoplasms who underwent surgical resection and dental implant rehabilitation | Patients with head and neck neoplasms with dental implants (n=2,448 patients; 10,164 implants) |
| Intervention | Dental implant treatment and rehabilitation; exposures include predefined risk factors (e.g., radiotherapy, bone grafting) | Dental implants; exposures: radiotherapy, chemotherapy, HBO, bone and soft tissue grafting, implant site, timing, prosthesis type (n=42 studies) |
| Comparison | Absence of the specific exposure or a different state of the factor (e.g., non-irradiated vs irradiated bone) | No radiotherapy; no chemotherapy; no HBO; native bone; mandible; posterior site; delayed placement; removable prosthesis; male sex; non-smokers; T3-T4 |
| Outcomes | Implant survival rate (primary); factors influencing implant survival (secondary) | Implant survival: pooled 88% (95% CI 85 to 90); RR for 14 risk factors |
| Study designs | RCTs, prospective cohort, retrospective cohort and case-control studies; minimum 12 months follow-up; English language | Observational studies (42 studies; NOS scores 6 to 9) |
| Timing | Minimum follow-up 12 months | Follow-up 1 to 12 years |