Non-Cochrane · aetiology · PM42798468
Dietary inflammatory potential and oral cancer risk: a meta-analysis of observational studies.
Li Bin, Chen Jie, Yu Pengkui · Frontiers in oncology · 2026 · PubMed · doi:10.3389/fonc.2026.1913476
Findings
Population People assessed for oral cancer risk
27 findings
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Trim-and-fill sensitivity analysis | OR 1.73 [1.28, 2.34] GRADE not reported 7 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: omitted Shivappa et al. (2017) Unresolved: the two extractors disagree on this row. | no estimate extracted GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: omitted Secchi et al. (2019) Unresolved: the two extractors disagree on this row. | no estimate extracted GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: omitted Mazul et al. (2018) Unresolved: the two extractors disagree on this row. | no estimate extracted GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: omitted Abe et al. (2018) Unresolved: the two extractors disagree on this row. | no estimate extracted GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: upper reported endpoint | OR 2.15 [1.62, 2.85] GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: lower reported endpoint | OR 1.82 [1.37, 2.2] GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: omitted Liang et al. (2024) | OR 2.15 [1.62, 2.85] GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: omitted Bao et al. (2020) Unresolved: the two extractors disagree on this row. | no estimate extracted GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Leave-one-out: omitted Narmcheshm et al. (2024) Unresolved: the two extractors disagree on this row. | no estimate extracted GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Overall | OR 1.92 [1.41, 2.62] GRADE not reported 7 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Study design: cohort | OR 0.98 [0.69, 1.39] GRADE not reported 1 study |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Study design: case-control | OR 2.15 [1.62, 2.85] GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Region: Asia | OR 2.00 [1.40, 2.85] GRADE not reported 3 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Region: Europe | OR 1.43 [0.68, 2.99] GRADE not reported 2 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Region: Americas | OR 5.22 [0.78, 35.09] GRADE not reported 2 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Number of cases: ≥ 200 | OR 2.27 [1.78, 2.88] GRADE not reported 3 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Number of cases: < 200 | OR 1.69 [1.03, 2.78] GRADE not reported 4 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Publication year: ≥ 2020 | OR 1.53 [0.99, 2.35] GRADE not reported 3 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Publication year: < 2020 | OR 2.37 [1.71, 3.29] GRADE not reported 4 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer NOS score: ≥ 7 | OR 1.78 [0.89, 3.60] GRADE not reported 3 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer NOS score: < 7 | OR 2.04 [1.42, 2.93] GRADE not reported 4 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Dietary index: IDI | OR 0.98 [0.69, 1.39] GRADE not reported 1 study |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Dietary index: DII | OR 2.15 [1.62, 2.85] GRADE not reported 6 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Adjusted variables: ≥ 5 | OR 2.01 [1.60, 2.54] GRADE not reported 5 studies |
| Highest category of dietary inflammatory potential | Lowest category of dietary inflammatory potential | Oral cancer Adjusted variables: < 5 | OR 3.52 [0.20, 61.08] GRADE not reported 2 studies |
| One-unit increase in dietary inflammatory potential score | One unit lower dietary inflammatory potential score | Oral cancer Overall | OR 1.19 [1.07, 1.32] GRADE not reported 5 studies |
Included primary studies 13
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Abe 2018 Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults. PMID:29844870 | 2018 | this review only | not stated | not extracted yet |
| Abe et al. 2018 Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults DOI:10.18632/oncotarget.25288 | 2018 | this review only | not stated | not extracted yet |
| Bao 2020 Association between dietary inflammatory index and the risk of oral cancer in the southeast of China. PMID:31575972 | 2020 | this review only | not stated | not extracted yet |
| Bao et al. 2020 Association between dietary inflammatory index and the risk of oral cancer in the southeast of China DOI:10.1038/s41430-019-0507-9 | 2019 | this review only | not stated | not extracted yet |
| Liang 2024 The association of the dietary inflammatory potential with risk of overall and site-specific cancers: A community-based longitudinal study… PMID:38582035 | 2024 | this review only | Oral cancer | not extracted yet |
| Liang et al. 2024 The association of the dietary inflammatory potential with risk of overall and site-specific cancers: A community-based longitudinal study… DOI:10.1016/j.jnha.2024.100225 | 2024 | this review only | not stated | not extracted yet |
| Mazul 2018 Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer. PMID:29696631 | 2018 | this review only | Oral cancer | not extracted yet |
| Mazul et al. 2018 Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer DOI:10.1002/ijc.31555 | 2018 | this review only | not stated | not extracted yet |
| Narmcheshm 2024 Dietary Inflammatory Index and Head and Neck Cancer: A Multicenter Case-Control Study in Iran. PMID:39311107 | 2024 | this review only | not stated | not extracted yet |
| Secchi 2019 The inflammatory potential of Argentinian diet and oral squamous cell carcinoma. PMID:31516012 | 2019 | this review only | not stated | not extracted yet |
| Secchi et al. 2019 The inflammatory potential of Argentinian diet and oral squamous cell carcinoma DOI:10.20960/nh.02613 | 2019 | this review only | not stated | not extracted yet |
| Shivappa 2017 Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy. PMID:28340515 | 2017 | this review only | not stated | not extracted yet |
| Shivappa et al. 2017 Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy DOI:10.1002/ijc.30711 | 2017 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Humans in observational studies with oral cancer confirmed by pathological or histological examination | Adults in China, Iran, Japan, Italy, UK, USA and Argentina; 27 to 295 cases; 86 to over 170,000 controls or cohort members (n=7) |
| Intervention | Dietary inflammatory potential score (e.g. DII, IDI) calculated from a validated FFQ; highest category and per 1-unit increment | Highest DII category (n=6) or IDI category (n=1); per 1-unit score increment (n=5) |
| Comparison | Lowest category of dietary inflammatory potential score | Lowest category of dietary inflammatory potential score (n=7) |
| Outcomes | Incidence of oral cancer (OR, RR or HR with 95% CI) | Oral cancer risk, highest vs lowest category (n=7); per 1-unit increment (n=5) |
| Study designs | Observational studies: cohort and case-control | 6 case-control studies and 1 cohort study (n=7) |
| Timing | Not specified | Not specified |