Non-Cochrane · DTA · PM42708877
Primary pulmonary salivary gland-type tumors in cytopathology practice: A systematic review and meta-analysis.
Lagerstam Henri, Kalfert David, Kholová Ivana · Cancer cytopathology · 2026 · PubMed · doi:10.1002/cncy.70153
Findings
14 findings
| Population | ||||
|---|---|---|---|---|
| Patients with histologically confirmed primary pulmonary salivary gland-type tumors | Final cytologic diagnosis | Histologic diagnosis | Cytohistologic concordance | Proportion .481 GRADE not reported 106 participants |
| Patients with histologically confirmed primary pulmonary salivary gland-type tumors | Fine-needle aspiration | Histologic diagnosis | Cytohistologic concordance | Proportion .750 GRADE not reported 44 participants |
| Patients with histologically confirmed primary pulmonary salivary gland-type tumors | Bronchoalveolar lavage | Histologic diagnosis | Cytohistologic concordance | Proportion .167 GRADE not reported 12 participants |
| Patients with histologically confirmed primary pulmonary salivary gland-type tumors | Bronchial aspiration | Histologic diagnosis | Cytohistologic concordance | Proportion .000 GRADE not reported 14 participants |
| Patients with histologically confirmed primary pulmonary salivary gland-type tumors | Bronchial/tracheal washing | Histologic diagnosis | Cytohistologic concordance | Proportion .381 GRADE not reported 21 participants |
| Patients with histologically confirmed primary pulmonary salivary gland-type tumors | Bronchial brushing | Histologic diagnosis | Cytohistologic concordance | Proportion .342 GRADE not reported 38 participants |
| Patients with histologically confirmed primary pulmonary salivary gland-type tumors | Sputum | Histologic diagnosis | Cytohistologic concordance | Proportion .077 GRADE not reported 13 participants |
| Patients with histologically confirmed primary pulmonary salivary gland-type tumors | Sampling method not determined | Histologic diagnosis | Cytohistologic concordance | Proportion .000 GRADE not reported 3 participants |
| Patients with histologically confirmed pulmonary adenoid cystic carcinoma | Cytologic diagnosis | Histologic diagnosis | Cytohistologic concordance | Proportion .567 [.438, .696] GRADE not reported Studies not reported |
| Patients with histologically confirmed pulmonary mucoepidermoid carcinoma | Cytologic diagnosis | Histologic diagnosis | Cytohistologic concordance | Proportion .540 [.299, .782] GRADE not reported Studies not reported |
| Patients with histologically confirmed pulmonary adenoid cystic carcinoma | Fine-needle aspiration | Histologic diagnosis | Cytohistologic concordance | Proportion .659 [.534, .784] GRADE not reported 18 studies · 23 participants |
| Patients with histologically confirmed pulmonary adenoid cystic carcinoma | Bronchial/tracheal washing | Histologic diagnosis | Cytohistologic concordance | Proportion .485 [.260, .710] GRADE not reported 11 studies · 20 participants |
| Patients with histologically confirmed pulmonary adenoid cystic carcinoma | Bronchial brushing | Histologic diagnosis | Cytohistologic concordance | Proportion .504 [.359, .650] GRADE not reported 26 participants |
| Patients with histologically confirmed pulmonary adenoid cystic carcinoma | Bronchial brushing | Histologic diagnosis | Cytohistologic concordance Unresolved: the two extractors disagree on this row. | Proportion .485 [.260, .710] GRADE not reported 11 studies · 20 participants |
Included primary studies 92
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Zhou 2023 matched by author and year (probable) | NR | 2 other reviews | not stated | not extracted yet |
| Kaur 2019 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Ayed 2024 Tracheal adenoid cystic carcinoma presenting as a locally advanced thyroid gland carcinoma DOI:10.1016/j.radcr.2024.11.058 | 2025 | this review only | not stated | not extracted yet |
| Ayed 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bhalara 2022 A Rare Case about Cytomorphology of Primary Adenoid Cystic Carcinoma of Lung DOI:10.9734/bpi/idmmr/v10/1744b | 2022 | this review only | not stated | not extracted yet |
| Bhalara 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Brooks & Baandrup 1992 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Brooks 1992 Peripheral low-grade mucoepidermoid carcinoma of the lung--needle aspiration cytodiagnosis and histology. PMID:1421009 | 1992 | this review only | not stated | not extracted yet |
| Charles 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Charles 2022 Pulmonary epithelial-myoepithelial carcinoma (P-EMC) with focal high grade transformation: Molecular and cytologic findings. PMID:35100487 | 2022 | this review only | not stated | not extracted yet |
| Chen 1996 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chen 1996 Exfoliative cytology of tracheobronchial adenoid cystic carcinoma. PMID:8872436 | 1996 | this review only | not stated | not extracted yet |
| Chon 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chon 2011 Primary peripheral pulmonary adenoid cystic carcinoma: report of a case diagnosed by fine needle aspiration cytology. PMID:20607807 | 2011 | this review only | not stated | not extracted yet |
| Chuah 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chuah 2007 Diagnosis of adenoid cystic carcinoma of the lung by bronchial brushing: a case report. PMID:17718122 | 2007 | this review only | not stated | not extracted yet |
| Cwierzyk 1985 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Cwierzyk 1985 Pulmonary oncocytoma. Report of a case with cytologic, histologic and electron microscopic study. PMID:2992204 | 1985 | this review only | not stated | not extracted yet |
| Daneshbod 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Daneshbod 2007 Exfoliative cytologic findings of primary pulmonary adenoid cystic carcinom: a report of 2 cases with a review of the cytologic features. PMID:17718121 | 2007 | this review only | not stated | not extracted yet |
| Delpiano 2000 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Delpiano 2000 Cytological appearance of papillary mucous gland adenoma of the left lobar bronchus with histological confirmation. PMID:10877281 | 2000 | this review only | not stated | not extracted yet |
| Doxtader 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Doxtader 2019 Primary salivary gland-type tumors of the tracheobronchial tree diagnosed by transbronchial fine needle aspiration: Clinical and… PMID:31343850 | 2019 | this review only | not stated | not extracted yet |
| Dyhdalo 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Dyhdalo 2013 Endobronchial ultrasound-guided fine-needle aspiration cytology of bronchial low-grade mucoepidermoid carcinoma: Rapid on-site evaluation… PMID:23008143 | 2013 | this review only | not stated | not extracted yet |
| Fei 2024 Adenoid cystic carcinoma of trachea mimicking a thyroid follicular tumor: A case report and literature review DOI:10.1016/j.radcr.2024.08.085 | 2024 | this review only | not stated | not extracted yet |
| Florentine 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Florentine 2006 Extra-salivary gland presentations of adenoid cystic carcinoma: a report of three cases. PMID:16783770 | 2006 | this review only | not stated | not extracted yet |
| Gao 2021 A Case of Solid Variant of Adenoid Cystic Carcinoma from Trachea: A Case Report and Review of Literature DOI:10.2147/ott.s296400 | 2021 | this review only | not stated | not extracted yet |
| Gupta & McHutchison 1992 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gupta 1992 Cytologic findings of adenoid cystic carcinoma in a tracheal wash specimen. PMID:1314732 | 1992 | this review only | not stated | not extracted yet |
| Idowu 2004 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Idowu 2004 Adenoid cystic carcinoma: a pitfall in aspiration cytology of the thyroid. PMID:15080307 | 2004 | this review only | not stated | not extracted yet |
| Ishikawa 2022 Histopathology and Cytology of Pulmonary Myoepithelial Neoplasms: 2 Cases DOI:10.1159/000524769 | 2022 | this review only | not stated | not extracted yet |
| Ishikawa 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Jayaprakash 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Jayaprakash 2014 Mucoepidermoid lung carcinoma in child. PMID:24761253 | 2014 | this review only | not stated | not extracted yet |
| Jikuzono 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Jikuzono 2022 Clinical Utility of Fine-Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report. PMID:33867428 | 2022 | this review only | not stated | not extracted yet |
| Kagotani 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kagotani 2014 Cytological features of dedifferentiated adenoid cystic carcinoma of the trachea: a case report. PMID:24574373 | 2014 | this review only | not stated | not extracted yet |
| Kapatia 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kapatia 2020 Fine-needle aspiration cytology of extra-salivary adenoid cystic carcinoma. PMID:31743547 | 2020 | this review only | not stated | not extracted yet |
| Kaur 2019 Fine-needle aspiration cytology of an adenoid cystic carcinoma of trachea: Common tumor in uncommon location. PMID:30953393 | 2019 | this review only | not stated | not extracted yet |
| Kim 2011 Bronchial Brushing Cytologic Finding of Primary Pulmonary Adenoid Cystic Carcinoma Misinterpretated as Small Cell Carcinoma - A Case… DOI:10.4132/koreanjpathol.2011.45.4.441 | 2011 | this review only | not stated | not extracted yet |
| Kim 2015 Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid… PMID:26477588 | 2015 | this review only | not stated | not extracted yet |
| Kukwa 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kukwa 2014 Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report. PMID:25120714 | 2014 | this review only | not stated | not extracted yet |
| Kumar & Monabati 1998 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kumar 1998 Bronchial oncocytoma diagnosed by brushing cytology. PMID:9684608 | 1998 | this review only | not stated | not extracted yet |
| Laforga & Aranda 1999 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Laforga 1999 Multicentric oncocytoma of the lung diagnosed by fine-needle aspiration. PMID:10405810 | 1999 | this review only | not stated | not extracted yet |
| Lozowski 1983 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lozowski 1983 Cytopathologic features of adenoid cystic carcinoma. Case report and literature review. PMID:6306972 | 1983 | this review only | not stated | not extracted yet |
| Mohammadnia 2020 Tracheal Adenoid Cystic Carcinoma Presented with Chronic Asthma Diagnosed by Bronchial Washing Cytology DOI:10.1155/2020/6543097 | 2020 | this review only | not stated | not extracted yet |
| Mohammadnia 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Monaco 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Monaco 2012 The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: a report of 16 patients. PMID:21591276 | 2012 | this review only | not stated | not extracted yet |
| Ng 2023 Bronchial cytology of pulmonary adenoid cystic carcinoma - A multi-institute series with emphasis on immunocytochemistry. PMID:36963153 | 2023 | this review only | not stated | not extracted yet |
| Nguyen 1988 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nguyen 1988 Cytology of bronchial gland carcinoma. PMID:2831689 | 1988 | this review only | not stated | not extracted yet |
| Nuwal 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nuwal 2010 Primary adenoid cystic carcinoma of trachea presenting as midline neck swelling and mimicking thyroid tumor: A case report and review of… PMID:20931039 | 2010 | this review only | not stated | not extracted yet |
| Özkara & Turan 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Özkara 2009 Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report. PMID:20014565 | 2009 | this review only | not stated | not extracted yet |
| Puzyrenko 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Puzyrenko 2021 Primary pulmonary mucoepidermoid carcinoma: Cyto-histologic correlation and review of the literature. PMID:33450549 | 2021 | this review only | not stated | not extracted yet |
| Qiu 2004 Primary pulmonary adenoid cystic carcinoma: report of a case diagnosed by fine-needle aspiration cytology. PMID:14696146 | 2004 | this review only | not stated | not extracted yet |
| Radhika 1993 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Radhika 1993 Adenoid cystic carcinoma in a bronchial washing. A case report. PMID:7679538 | 1993 | this review only | not stated | not extracted yet |
| Romagosa 2002 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Romagosa 2002 Intranuclear inclusions in fine needle aspirates of bronchial low grade mucoepidermoid carcinoma with clear cell change: a report of two… PMID:11843560 | 2002 | this review only | not stated | not extracted yet |
| Saglietti 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Saglietti 2017 Cytology of Primary Salivary Gland-Type Tumors of the Lower Respiratory Tract: Report of 15 Cases and Review of the Literature. PMID:28484699 | 2017 | this review only | not stated | not extracted yet |
| Scherl 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Scherl 2013 Rare tracheal tumors and lesions initially diagnosed as isolated differentiated thyroid cancers. PMID:23072609 | 2013 | this review only | not stated | not extracted yet |
| Segletes 1999 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Segletes 1999 Cytology of primary pulmonary mucoepidermoid and adenoid cystic carcinoma. A report of four cases. PMID:10578983 | 1999 | this review only | not stated | not extracted yet |
| Tao & Robertson 1978 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tao 1978 Cytologic diagnosis of bronchial mucoepidermoid carcinoma by fine needle aspiration biopsy. PMID:281824 | 1978 | this review only | not stated | not extracted yet |
| Vallonthaiel 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Vallonthaiel 2017 c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas. PMID:27974718 | 2017 | this review only | not stated | not extracted yet |
| Watanabe 2004 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Watanabe 2004 Fine-needle aspiration cytology of bronchial acinic cell carcinoma: a case report. PMID:15108238 | 2004 | this review only | not stated | not extracted yet |
| White 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| White 2021 A Rare Case of Primary Pulmonary Adenoid Cystic Carcinoma and the Diagnostic Challenges on Cytology. PMID:34449997 | 2021 | this review only | not stated | not extracted yet |
| Yokouchi 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yokouchi 2007 Primary peripheral adenoid cystic carcinoma of the lung and literature comparison of features. PMID:17978538 | 2007 | this review only | not stated | not extracted yet |
| Zhou 2019 Challenges in diagnosis of pulmonary mucoepidermoid carcinoma DOI:10.1097/md.0000000000017684 | 2019 | this review only | not stated | not extracted yet |
| Zhou 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zhou 2023 A cytodiagnosis of adenoid cystic carcinoma of the tracheobronchial tree through a systematic clinical case comparison and analysis DOI:10.1186/s12890-023-02628-9 | 2023 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with a histologically confirmed primary salivary gland-type tumor of the lung or tracheobronchial tree with cytologic evaluation | 106 patients from 49 studies (67 AdCC, 27 MEC, 4 oncocytoma, 3 EMC, 1 each acinic cell carcinoma, myoepithelioma, myoepithelial carcinoma, mucous gland adenoma, HCCC) |
| Intervention | Cytologic sampling (fine-needle aspiration, bronchial brushing, bronchial/tracheal washing, BAL, bronchial aspiration, sputum) | FNA (n=44), bronchial brushing (n=38), bronchial/tracheal washing (n=21), bronchial aspiration (n=14), sputum (n=13), BAL (n=12), not determined (n=3) |
| Comparison | Histologic diagnosis (reference standard) | Final histologic diagnosis |
| Outcomes | Cytohistologic concordance; clinical characteristics, treatment and follow-up outcome | Cytohistologic concordance overall 48.1%; FNA 75.0%, washing 38.1%, brushing 34.2%, BAL 16.7%, sputum 7.7%; pooled AdCC 56.7%, MEC 54.0% |
| Study designs | Not specified | Case reports and small case series (49 studies) |
| Timing | Not specified | Not specified |