Non-Cochrane · aetiology · PM42558143
Association of oxidative stress-related gst gene polymorphisms with periodontitis susceptibility: A systematic review and meta-analysis.
Motahari Paria, Neshanifard Negin · Journal of advanced periodontology & implant dentistry · 2026 · PubMed · doi:10.34172/japid.026.3866
Findings
Population Adults (18 years or older) with periodontitis versus periodontally healthy controls
35 findings
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) European | OR 1.42 [1.03, 1.95] GRADE not reported 3 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Sample size n>=100 | OR 2.54 [1.93, 3.35] GRADE not reported 3 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Sample size n<100 | OR 2.29 [1.47, 3.56] GRADE not reported 3 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Resende et al | OR 3.047 [1.004, 9.245] GRADE not reported 5 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Arshad et al | OR 1.807 [1.206, 2.708] GRADE not reported 5 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) | OR 2.94 [1.13, 7.63] Moderate Downgraded: risk of bias, imprecision, inconsistency 6 studies · 1444 participants |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Concolino et al | OR 2.434 [1.902, 3.115] GRADE not reported 5 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Asian | OR 4.71 [3.34, 6.65] GRADE not reported 3 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Kim et al | OR 2.559 [1.97, 3.324] GRADE not reported 5 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Msolly et al | OR 3.225 [1.046, 9.945] GRADE not reported 5 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Heavy smokers (high-frequency consumers) | OR 5.2 [1.07, 25.14] GRADE not reported 3 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Izakovicova et al | OR 3.658 [1.303, 10.268] GRADE not reported 5 studies |
| GSTM1-null genotype | GSTM1-present genotype | Odds of periodontitis (case-control genotype association) Light smokers (low-frequency consumers) | OR 1.51 [0.89, 2.57] GRADE not reported 3 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) | OR 0.64 [0.38, 1.09] Low Downgraded: imprecision 5 studies · 1305 participants |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Arshad et al | OR 0.78 [0.555, 1.096] GRADE not reported 4 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) European | OR 0.7 [0.48, 1.01] GRADE not reported 3 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Izakovicova et al | OR 0.651 [0.307, 1.381] GRADE not reported 4 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Sample size n>=100 | OR 0.44 [0.2, 0.95] GRADE not reported 2 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Sample size n<100 | OR 0.94 [0.58, 1.54] GRADE not reported 3 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Light smokers (low-frequency consumers) | OR 0.79 [0.53, 1.16] GRADE not reported 3 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Heavy smokers (high-frequency consumers) | OR 0.46 [0.18, 1.17] GRADE not reported 2 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Concolino et al | OR 0.616 [0.323, 1.175] GRADE not reported 4 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Msolly et al | OR 0.538 [0.318, 0.908] GRADE not reported 4 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Sensitivity: leave-one-out excluding Resende et al | OR 0.627 [0.339, 1.159] GRADE not reported 4 studies |
| GSTT1-null genotype | GSTT1-present genotype | Odds of periodontitis (case-control genotype association) Asian | OR 0.59 [0.15, 2.43] GRADE not reported 2 studies |
| GSTP1 rs1695 G allele | GSTP1 rs1695 A allele | Odds of periodontitis (case-control genotype association) Sensitivity: excluding Arshad et al (control HWE P=0.001) | OR 0.9 [0.67, 1.21] GRADE not reported 2 studies |
| GSTP1 rs1695 G allele | GSTP1 rs1695 A allele | Odds of periodontitis (case-control genotype association) Unresolved: the two extractors disagree on this row. | OR 1.56 [1.22, 1.99] Low Downgraded: inconsistency 3 studies · 1000 participants |
| GSTP1 rs1695 GG genotype | GSTP1 rs1695 AA genotype | Odds of periodontitis (case-control genotype association) Unresolved: the two extractors disagree on this row. | OR 1.98 [1.09, 3.6] Low Downgraded: inconsistency 3 studies · 1000 participants |
| GSTP1 rs1695 GG genotype | GSTP1 rs1695 AA genotype | Odds of periodontitis (case-control genotype association) Sensitivity: excluding Arshad et al (control HWE P=0.001) | OR 0.92 [0.45, 1.88] GRADE not reported 2 studies |
| GSTP1 rs1695 AG genotype | GSTP1 rs1695 AA genotype | Odds of periodontitis (case-control genotype association) Unresolved: the two extractors disagree on this row. | OR 1.47 [1.07, 2.03] Low Downgraded: inconsistency 3 studies · 1000 participants |
| GSTP1 rs1695 AG genotype | GSTP1 rs1695 AA genotype | Odds of periodontitis (case-control genotype association) Sensitivity: excluding Arshad et al (control HWE P=0.001) | OR 0.84 [0.57, 1.25] GRADE not reported 2 studies |
| GSTP1 rs1695 AG+GG genotypes | GSTP1 rs1695 AA genotype | Odds of periodontitis (case-control genotype association) Sensitivity: excluding Arshad et al (control HWE P=0.001) | OR 0.85 [0.59, 1.24] GRADE not reported 2 studies |
| GSTP1 rs1695 AG+GG genotypes | GSTP1 rs1695 AA genotype | Odds of periodontitis (case-control genotype association) Unresolved: the two extractors disagree on this row. | OR 1.64 [1.22, 2.22] Low Downgraded: inconsistency 3 studies · 1000 participants |
| GSTP1 rs1695 GG genotype | GSTP1 rs1695 AG+AA genotypes | Odds of periodontitis (case-control genotype association) Unresolved: the two extractors disagree on this row. | OR 1.84 [1.03, 3.3] Low Downgraded: inconsistency 3 studies · 1000 participants |
| GSTP1 rs1695 GG genotype | GSTP1 rs1695 AG+AA genotypes | Odds of periodontitis (case-control genotype association) Sensitivity: excluding Arshad et al (control HWE P=0.001) | OR 0.98 [0.49, 1.96] GRADE not reported 2 studies |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Arshad 2023 Association of GSTTI, M1 and Polymorphism in GSTPI with Chronic Periodontal Disease in a Pakistani Population. PMID:36833382 | 2023 | 1 other review | Odds of periodontitis (case-control genotype association) | not extracted yet |
| Concolino 2007 Association of periodontitis with GSTM1/GSTT1-null variants--a pilot study. PMID:17524385 | 2007 | 1 other review | Odds of periodontitis (case-control genotype association) | not extracted yet |
| Izakovicova 2024 Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study. PMID:38419025 | 2024 | 1 other review | Odds of periodontitis (case-control genotype association) | not extracted yet |
| Kim 2004 Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis. PMID:15491310 | 2004 | 1 other review | Odds of periodontitis (case-control genotype association) | not extracted yet |
| Saravanan 2023 Genetic association between rs1695 in glutathione S-transferase P1 and risk of periodontitis: a pilot study. PMID:37886736 | 2023 | 1 other review | Odds of periodontitis (case-control genotype association) | not extracted yet |
| Msolly 2015 matched by author and year (probable) | NR | this review only | Odds of periodontitis (case-control genotype association) | not extracted yet |
| Resende 2013 Rethinking patient-ventilator asynchronies: toward a mechanism-based framework-Author's reply. PMID:42201358 | 2026 | this review only | Odds of periodontitis (case-control genotype association) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Association of GSTM1, GSTT1, and GSTP1 Gene Polymorphisms With Susceptibility to Periodontitis: A Systematic Review and Meta-Analysis With… (2026) | 5 | 0.31 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (>=18 years) with clinically or radiographically defined periodontitis | Adults with periodontitis and healthy controls; 752 cases and 773 controls (n=1525; 7 studies) |
| Intervention | Presence of GSTM1, GSTT1 or GSTP1 (rs1695) variants | GSTM1-null (n=6 studies); GSTT1-null (n=5 studies); GSTP1 rs1695 (n=3 studies) |
| Comparison | Periodontally healthy controls | Periodontally healthy controls (n=773) |
| Outcomes | Odds of periodontitis (OR, 95% CI) | Odds of periodontitis (OR) |
| Study designs | Observational studies (case-control, cohort, cross-sectional); full-text English articles | Case-control studies (n=7) |
| Timing | Not specified | Not specified |