Non-Cochrane · aetiology · PM42529147
Diversity and taxonomic differences in the oral microbiota of stroke patients: a systematic review and meta-analysis.
Chen Yinlian, Tian Yunxue, Jin Yingju, et al. · Frontiers in microbiology · 2026 · PubMed · doi:10.3389/fmicb.2026.1874193
Findings
Population Adults with clinically or radiologically confirmed stroke (any type)
14 findings
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Chao1 alpha diversity Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall | SMD 0.17 [-0.4, 0.73] Low Downgraded: imprecision, inconsistency 8 studies · 661 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Actinomycetota relative abundance Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall | SMD -0.04 [-0.24, 0.17] Low 2 studies · 368 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Fusobacteriota relative abundance Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall | SMD -0.1 [-0.46, 0.27] Very low Downgraded: imprecision, inconsistency 3 studies · 499 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Bacteroidota relative abundance Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall | SMD 0.36 [0.18, 0.54] Low 3 studies · 499 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Proteobacteria (Pseudomonadota) relative abundance Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall | SMD -0.48 [-1.02, 0.06] Low Downgraded: inconsistency 3 studies · 499 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Proteobacteria (Pseudomonadota) relative abundance Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Sensitivity analysis omitting Manzoor 2024 | SMD -0.68 GRADE not reported 2 studies |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Bacteroidota relative abundance Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Sensitivity analysis omitting Manzoor 2024 | SMD 0.62 GRADE not reported 2 studies |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Bacteroidota relative abundance Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall (estimate in GRADE table) | SMD 0.43 [0.14, 0.71] Low 3 studies · 499 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Observed species alpha diversity Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Sensitivity analysis omitting Sun 2023 | SMD 0.13 [-0.06, 0.33] GRADE not reported 6 studies |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Shannon alpha diversity Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Sensitivity analysis omitting Sun 2023 | SMD 0.18 [-0.04, 0.4] GRADE not reported 9 studies |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Shannon alpha diversity Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall | SMD 0.31 [0.02, 0.61] Low Downgraded: inconsistency 10 studies · 1241 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Observed species alpha diversity Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall | SMD 0.39 [0.05, 0.72] Low Downgraded: inconsistency 7 studies · 1099 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Proteobacteria (Pseudomonadota) relative abundance Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall (estimate in GRADE table) | SMD -0.26 [-0.44, -0.07] Low Downgraded: inconsistency 3 studies · 499 participants |
| Stroke (oral microbiota of stroke patients) | Healthy adult controls without history of stroke | Simpson alpha diversity Single oral sample; collection from 24 h to 3 months after stroke (varies by study) · Overall | SMD 0.18 [-0.05, 0.41] Low 5 studies · 307 participants |
Included primary studies 11
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Yang 2022 matched by author and year (probable) | NR | 1 other review | Chao1 alpha diversity; Observed species alpha diversity; Shannon alpha diversity; Simpson alpha diversity | not extracted yet |
| Zhao 2025 matched by author and year (probable) | NR | 1 other review | Chao1 alpha diversity; Shannon alpha diversity; Simpson alpha diversity | not extracted yet |
| Chang 2024 matched by author and year (probable) | NR | this review only | Chao1 alpha diversity; Shannon alpha diversity; Simpson alpha diversity | not extracted yet |
| He 2024 The impact of dysbiosis in oropharyngeal and gut microbiota on systemic inflammatory response and short-term prognosis in acute ischemic… PMID:39238889 | 2024 | this review only | Chao1 alpha diversity; Shannon alpha diversity; Simpson alpha diversity; Actinomycetota relative abundance; Bacteroidota relative abundance; Proteobacteria (Pseudomonadota) relative abundance; Fusobacteriota relative abundance | not extracted yet |
| Huang 2024 matched by author and year (probable) | NR | this review only | Chao1 alpha diversity; Observed species alpha diversity; Shannon alpha diversity | not extracted yet |
| Manzoor 2024 Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke DOI:10.1093/ismeco/ycae088 | 2024 | this review only | Observed species alpha diversity; Shannon alpha diversity; Actinomycetota relative abundance; Bacteroidota relative abundance; Proteobacteria (Pseudomonadota) relative abundance; Fusobacteriota relative abundance | not extracted yet |
| Manzoor 2025 Association of Subgingival Microbiota Composition With Risk, Severity, and Outcome of Cryptogenic Ischemic Stroke in Young Adults DOI:10.1161/jaha.125.043495 | 2025 | this review only | Observed species alpha diversity; Shannon alpha diversity | not extracted yet |
| Sun 2023 The oral microbiome of patients with ischemic stroke predicts their severity and prognosis. PMID:37138888 | 2023 | this review only | Chao1 alpha diversity; Observed species alpha diversity; Shannon alpha diversity | not extracted yet |
| Wang 2022 The Spouses of Stroke Patients Have a Similar Oral Microbiome to Their Partners with an Elevated Risk of Stroke. PMID:36422358 | 2022 | this review only | Chao1 alpha diversity; Observed species alpha diversity; Shannon alpha diversity; Simpson alpha diversity | not extracted yet |
| Yao 2025 Multi-omics profiling reveals key microbial and metabolic variations in ischemic stroke: insights into gut and oral microbiota DOI:10.1007/s00203-025-04494-x | 2025 | this review only | not stated | not extracted yet |
| Zheng 2026 DOI:10.13406/j.cnki.cyxb.004041 | NR | this review only | Chao1 alpha diversity; Observed species alpha diversity; Shannon alpha diversity; Bacteroidota relative abundance; Proteobacteria (Pseudomonadota) relative abundance; Fusobacteriota relative abundance | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (18 y or older) with clinically or radiologically confirmed stroke (any subtype) and healthy controls | 746 stroke patients and 552 healthy controls (n=11 studies) |
| Intervention | Stroke (oral microbiota from saliva, gingival crevicular fluid, subgingival plaque or oropharyngeal swabs) | Stroke; oral microbiota (n=11) |
| Comparison | Healthy adults without stroke history, comparable in age and sex | Healthy controls (n=11) |
| Outcomes | Alpha diversity, beta diversity, relative abundance at phylum and genus level | Chao1 (n=8), Observed species (n=7), Shannon (n=10), Simpson (n=5), beta diversity (n=9), phyla Actinomycetota (n=2), Bacteroidota (n=3), Proteobacteria (n=3), Fusobacteriota (n=3) |
| Study designs | Observational studies comparing stroke patients and healthy controls | Case-control studies (n=11) |
| Timing | Not specified | Samples collected 24 h to 3 months after stroke |