Non-Cochrane · intervention · PM42523940
Comparison of Remineralization Potential of Different Remineralizing Agents on Carious Lesion of Primary Teeth: A Systematic Review and Meta-analysis.
Oza Aditi S, Salunkhe Bhagyashree, Patil Raju Umaji, et al. · International journal of clinical pediatric dentistry · 2026 · PubMed · doi:10.5005/jp-journals-10005-3535
Findings
Population Primary (deciduous) tooth specimens with artificially induced enamel caries-like lesions
5 findings
| Nanohydroxyapatite (nHA) | Sodium fluoride (NaF) | Vickers microhardness After remineralization · In vitro laboratory | SMD 0.01 [-1.13, 1.15] GRADE not reported 3 studies · 122 participants |
| Nanosilver fluoride (NSF) | Sodium fluoride (NaF) | Vickers microhardness After remineralization · In vitro laboratory | SMD 0.77 [0.13, 1.42] GRADE not reported 3 studies · 78 participants |
| Bioactive glass (BAG, including nano-BAG) | Sodium fluoride (NaF) | Vickers microhardness After remineralization · In vitro laboratory · Overall (BAG and nano-BAG subgroups combined) | SMD 1.00 [0.14, 1.86] GRADE not reported 4 studies · 200 participants |
| Bioactive glass (Novamin, BAG) | Sodium fluoride (NaF) | Vickers microhardness After remineralization · In vitro laboratory · Subgroup 1.2.1 BAG (Novamin) | SMD 0.27 [-0.13, 0.67] GRADE not reported 2 studies · 98 participants |
| Nano bioactive glass (nano-BAG) | Sodium fluoride (NaF) | Vickers microhardness After remineralization · In vitro laboratory · Subgroup 1.2.2 Nano-BAG | SMD 1.87 [0.27, 3.46] GRADE not reported 2 studies · 102 participants |
Included primary studies 16
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Sherif 2023 matched by author and year (probable) | NR | 1 other review | Vickers microhardness | not extracted yet |
| Baghal 2023 An In-vitro Comparative Study of Fluoride Varnish and Two Calcium-containing Fluoride Products on the Remineralization of Primary Teeth… DOI:10.18502/fid.v20i23.13167 | 2023 | this review only | not stated | not extracted yet |
| Bajaj 2016 Comparison of CPP-ACP, Tri-Calcium Phosphate and Hydroxyapatite on Remineralization of Artificial Caries Like Lesions on Primary Enamel… DOI:10.17796/1053-4628-40.5.404 | 2016 | this review only | not stated | not extracted yet |
| Benjasuwantep 2017 Biochemical cost of a fight in fed and fasted Betta splendens. PMID:2017485 | 1991 | this review only | not stated | not extracted yet |
| Deulkar 2023 matched by author and year (probable) | NR | this review only | Vickers microhardness | not extracted yet |
| El-Desouky 2022 Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study DOI:10.1186/s12903-022-02271-6 | 2022 | this review only | Vickers microhardness | not extracted yet |
| Elmancy 2022 matched by author and year (probable) | NR | this review only | Vickers microhardness | not extracted yet |
| Geleel 2022 Uncommon neurologic complications of burns in infants: a parkinsonian extrapyramidal disorder and massive cerebral infarction. PMID:2022683 | 1991 | this review only | Vickers microhardness | not extracted yet |
| Kocyigit 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Koçyiğit 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Meshki 2024 Comparison of the Effect of Bioglass, Chitosan, and SDF Compounds on Remineralization of Primary Caries Lesions in Primary Teeth: An in… PMID:39371959 | 2024 | this review only | not stated | not extracted yet |
| Nozari 2017 Impact of Nano Hydroxyapatite, Nano Silver Fluoride and Sodium Fluoride Varnish on Primary Teeth Enamel Remineralization: An In Vitro Study. PMID:29207844 | 2017 | this review only | Vickers microhardness | not extracted yet |
| Rakha 2020 matched by author and year (probable) | NR | this review only | Vickers microhardness | not extracted yet |
| Salama 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sebastian 2022 Comparison of Remineralization Potential of Casein Phosphopeptide: Amorphous Calcium Phosphate, Nano-hydroxyapatite and Calcium Sucrose… PMID:35528489 | 2022 | this review only | not stated | not extracted yet |
| Shihabi 2020 Comparative Remineralization Efficacy of Topical NovaMin and Fluoride on Incipient Enamel Lesions in Primary Teeth: Scanning Electron… DOI:10.1055/s-0040-1721311 | 2020 | this review only | Vickers microhardness | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| The importance of power in photobiomodulation: a systematic review and meta-analysis of high-intensity laser therapy. (2026) | 1 | 0.00 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | 6 to 14 years with primary dentition or tooth samples of deciduous teeth having incipient/early enamel caries | Primary (deciduous) tooth enamel specimens with artificial carious lesions (in vitro; 15 studies) |
| Intervention | Bioactive glass, nano bioactive glass, nano hydroxyapatite, nano silver fluoride | Bioactive glass, nano-BAG, nano-hydroxyapatite, nanosilver fluoride, hydroxyapatite |
| Comparison | Sodium fluoride, CPP-ACP, SDF, TCP, or plain fluoride | NaF (varnish, toothpaste, solution), CPP-ACP, TCP, SDF |
| Outcomes | Remineralization, microhardness, mineral content (also calcium and phosphorus concentration, surface roughness) | Vickers microhardness (meta-analysed; 8 studies), mineral density, lesion depth, surface roughness |
| Study designs | Clinical trials, in vivo and in vitro studies published in English until December 31, 2023 | 15 in vitro studies (8 in meta-analysis) |
| Timing | Not specified | After remineralization |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | Yes | No | no |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: N/A · NRSI: N/A | NRSI: No · RCT: N/A | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | NRSI: Yes · RCT: N/A | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | No | No | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |