Non-Cochrane · prognostic · PM42516003
Prevalence of Peri-Implantitis Around Zirconia Implants: A Systematic Review and Meta-Analysis of Current Evidence.
Moraschini Vittorio, de Moraes João Baptista, de Oliveira Silva Alice Maria, et al. · Clinical implant dentistry and related research · 2026 · PubMed · doi:10.1111/cid.70176
Findings
8 findings
| Population | ||||
|---|---|---|---|---|
| Patients with zirconia implants in function for at least 12 months | Zirconia implants | None (single-arm prevalence) | Peri-implantitis prevalence (implant level) Follow-up <= 3 years · Dental implant clinics · Follow-up <= 3 years | Prevalence (%) 2 [0, 6] GRADE not reported 10 studies · 533 participants |
| Patients with zirconia implants in function for at least 12 months | Zirconia implants | None (single-arm prevalence) | Peri-implantitis prevalence (implant level) Follow-up > 3 to 5 years · Dental implant clinics · Follow-up > 3 to 5 years | Prevalence (%) 2 [0, 8] GRADE not reported 5 studies · 149 participants |
| Patients with zirconia implants in function for at least 12 months | Zirconia implants | None (single-arm prevalence) | Peri-implantitis prevalence (implant level) Follow-up > 5 years · Dental implant clinics · Follow-up > 5 years | Prevalence (%) 10 [0, 32] Very low Downgraded: imprecision, inconsistency 3 studies · 137 participants |
| Patients with zirconia implants in function for at least 12 months | Zirconia implants | None (single-arm prevalence) | Peri-implantitis prevalence (implant level) Follow-up <= 3 years · Dental implant clinics · Follow-up <= 3 years | Prevalence (%) 1 [0, 5] Very low Downgraded: risk of bias, imprecision, inconsistency 11 studies · 579 participants |
| Patients with zirconia implants in function for at least 12 months | Zirconia implants | None (single-arm prevalence) | Peri-implantitis prevalence (implant level) Follow-up > 5 years · Dental implant clinics · Follow-up > 5 years | Prevalence (%) 8 [0, 23] GRADE not reported 4 studies · 165 participants |
| Patients with zirconia implants in function for at least 12 months | Zirconia implants | None (single-arm prevalence) | Peri-implantitis prevalence (implant level) Follow-up > 3 to 5 years · Dental implant clinics · Follow-up > 3 to 5 years | Prevalence (%) 2 [0, 5] Low Downgraded: risk of bias, imprecision 6 studies · 221 participants |
| Patients receiving zirconia or titanium implants in RCTs | Zirconia implants | Titanium implants | Peri-implantitis prevalence (implant level) 12 to 60 months follow-up · Dental implant clinics | RR 1.13 [0.33, 3.91] Low Downgraded: risk of bias, imprecision 6 studies · 313 participants |
| Patients receiving zirconia or titanium implants in RCTs | Zirconia implants | Titanium implants | Peri-implantitis prevalence (implant level) 12 to 60 months follow-up · Dental implant clinics | RR 1.66 [0.48, 5.71] GRADE not reported 5 studies · 211 participants |
Included primary studies 19
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Balmer 2020 Zirconia implants restored with single crowns or fixed dental prostheses: 5-year results of a prospective cohort investigation. PMID:31981374 | 2020 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Borgonovo 2015 Zirconia Implants in Esthetic Areas: 4-Year Follow-Up Evaluation Study. PMID:26124836 | 2015 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Brunello 2022 Two-piece zirconia implants in the posterior mandible and maxilla: A cohort study with a follow-up period of 9 years. PMID:36184914 | 2022 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| da Silva 2024 Clinical and radiographic outcomes of a two-piece ceramic implant: one year results from a prospective clinical trial. PMID:38886209 | 2024 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| de Beus 2024 A randomized clinical trial on zirconia versus titanium implants in maxillary single tooth replacement. PMID:38567929 | 2024 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Grassi 2015 Immediate occlusal loading of one-piece zirconia implants: five-year radiographic and clinical evaluation. PMID:26009919 | 2015 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Hassouna 2022 Clinical and radiographic prospective study of customized one-piece titanium and one-piece fusion-sputtered zirconia implants: five-year… PMID:36424624 | 2022 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Henao 2024 Single-piece zirconia versus single-piece titanium, narrow-diameter dental implants in the anterior maxilla: 5-year post-loading results… PMID:38940623 | 2024 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Hollander 2016 Zirconia Dental Implants: Investigation of Clinical Parameters, Patient Satisfaction, and Microbial Contamination. PMID:27447153 | 2016 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Jung 2016 Evaluation of a one-piece ceramic implant used for single-tooth replacement and three-unit fixed partial dentures: a prospective cohort… PMID:26212100 | 2016 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Karapataki 2023 Clinical Performance of Two-Piece Zirconia Dental Implants After 5 and Up to 12 Years. PMID:38085741 | 2023 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Kniha 2018 Peri-implant Crestal Bone Changes Around Zirconia Implants in Periodontally Healthy and Compromised Patients. PMID:29028851 | 2018 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Kohal 2018 One-piece zirconia oral implants for single-tooth replacement: Three-year results from a long-term prospective cohort study. PMID:28902420 | 2018 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Kohal 2023 One-Piece Zirconia Oral Implants for the Support of Three-Unit Fixed Dental Prostheses: Three-Year Results from a Prospective Case Series. PMID:36662092 | 2023 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Kohal 2025 One-piece zirconia oral implants supporting three-unit fixed dental prostheses: Ten-year results from a prospective case series. PMID:40518040 | 2025 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Lorenz 2019 Prospective controlled clinical study investigating long-term clinical parameters, patient satisfaction, and microbial contamination of… PMID:30714303 | 2019 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Payer 2015 All-ceramic restoration of zirconia two-piece implants--a randomized controlled clinical trial. PMID:24502675 | 2015 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Rodriguez 2018 Zirconia dental implants: A clinical and radiographic evaluation. PMID:30253041 | 2018 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
| Zuercher 2024 Clinical, radiographic and patient-reported outcomes of zirconia and titanium implants in the posterior zone after 1 year of loading-A… PMID:39056305 | 2024 | this review only | Peri-implantitis prevalence (implant level) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients who received zirconia implants in function for at least 12 months | 687 patients with 995 implants (891 zirconia, 104 titanium) |
| Intervention | Prosthetic rehabilitation supported by zirconia implants (single-unit, partial, or full-arch) | Zirconia implants, mostly one-piece (14 of 19 studies), mostly single crowns |
| Comparison | Titanium implants, when comparative data are available | Titanium implants in 5 RCTs (109 ZIs and 106 TIs) |
| Outcomes | Primary: implant-level (and patient-level when available) peri-implantitis prevalence; secondary: ZI versus TI difference in peri-implantitis prevalence; peri-implant clinical and radiographic parameters (PD, BOP, PI, MBL) | Implant-level peri-implantitis prevalence by follow-up (pooled); ZI vs TI RR (5 RCTs); PD, BOP, MBL, PI described only (no meta-analysis) |
| Study designs | RCTs, controlled clinical trials, and cohort studies | 5 RCTs, 12 prospective cohort studies, 2 retrospective studies |
| Timing | Zirconia implants in function at least 12 months | Mean follow-up 49 months (range 12 to 144) |