Non-Cochrane · other · PM42480137
Structural Neuroimaging Alterations in Primary Burning Mouth Syndrome: A Seed-Based d Mapping (SDM-PSI) Meta-Analysis.
Lu Chenghui, Jiang Mengyu, Wang Yanni, et al. · International dental journal · 2026 · PubMed · doi:10.1016/j.identj.2026.109754
Findings
Population Adults with primary burning mouth syndrome (pBMS) and healthy controls
4 findings
| Primary burning mouth syndrome (pBMS) | Healthy controls | Regional grey matter volume (voxel-wise SDM-PSI meta-analysis) Decreased GMV: left medial superior frontal gyrus (mPFC), MNI -8, 58, -2 | SDM-Z -3.341 GRADE not reported 4 studies · 122 participants |
| Primary burning mouth syndrome (pBMS) | Healthy controls | Regional grey matter volume (voxel-wise SDM-PSI meta-analysis) Jackknife sensitivity analysis of left mSFG reduction | Reduced GMV in the left mSFG remained significant in 2 of 4 leave-one-out combinations (remained when Sinding et al. or Lee et al. omitted; not when Khan et al. or Tan et al. omitted) GRADE not reported 4 studies · 122 participants |
| Primary burning mouth syndrome (pBMS) | Healthy controls | Regional grey matter volume (voxel-wise SDM-PSI meta-analysis) Increased GMV: no significant region | Structural meta-analysis, positive correlation with regional GMV: None GRADE not reported 4 studies · 122 participants |
| pBMS (resting-state functional connectivity, seed medial prefrontal cortex) | Healthy controls | Resting-state functional connectivity from mPFC seed (SDM meta-analysis) Increased connectivity: left amygdala, MNI -32, 0, -14 | SDM-Z 5.909 GRADE not reported 2 studies · 71 participants |
Included primary studies 8
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Sinding et al. 2016 Degradation of benzenesulfonate to sulfite in bacterial extract. PMID:201612 | 1977 | 2 other reviews | not stated | not extracted yet |
| Lee et al. 2018 The cyclic AMP control system in the development of Dictyostelium discoideum. I. Cellular dynamics. PMID:201810 | 1977 | 1 other review | not stated | not extracted yet |
| Khan 2014 Altered structure and function in the hippocampus and medial prefrontal cortex in patients with burning mouth syndrome. PMID:24769366 | 2014 | this review only | not stated | not extracted yet |
| Khan et al. 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lee 2018 Change in gray matter volume and cerebral blood flow in patients with burning mouth syndrome. PMID:30735586 | 2019 | this review only | not stated | not extracted yet |
| Sinding 2016 Grey matter changes of the pain matrix in patients with burning mouth syndrome. PMID:26741696 | 2016 | this review only | not stated | not extracted yet |
| Tan 2019 Structural and Functional Connectivity Between the Amygdala and Orbital Frontal Cortex in Burning Mouth Syndrome: An fMRI Study. PMID:31404248 | 2019 | this review only | not stated | not extracted yet |
| Tan et al. 2019 Central nervous system infections: long-term complications and management. PMID:201911 | 1977 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients diagnosed with primary burning mouth syndrome (ICHD criteria) | pBMS patients (n=59 structural; n=35 functional) from 4 VBM studies |
| Intervention | Neuroimaging: voxel-based grey matter analyses (T1-weighted) and resting-state functional connectivity (BOLD fMRI) | pBMS neuroimaging: 4 VBM studies; 2 resting-state fMRI studies (same participants as 2 of the VBM studies) |
| Comparison | Healthy controls or comparable reference group | Healthy controls (n=63 structural; n=36 functional) |
| Outcomes | Regional grey matter volume differences (peak coordinates); resting-state functional connectivity | Decreased GMV in left medial superior frontal gyrus (mPFC); exploratory increased mPFC-left amygdala functional connectivity |
| Study designs | Original human case-control studies in English or Chinese reporting MNI or Talairach coordinates | Case-control MRI studies (n=4) |
| Timing | Not specified | Not specified |