Non-Cochrane · intervention · PM42278933
Effect of Melatonin as an Adjunct to NSPT on Periodontal and Systemic Outcomes in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs.
Angelopoulou Thaleia, Bobetsis Yiorgos A · Journal of clinical medicine · 2026 · PubMed · doi:10.3390/jcm15114071
Findings
Population Patients with type 2 diabetes mellitus and periodontitis
7 findings
| Systemic melatonin (oral tablets, 6 mg/day for 8 weeks) as an adjunct to NSPT | NSPT plus placebo | CAL (clinical attachment level), change from baseline 8 weeks post-treatment · Periodontal clinics (Iran, Romania) | SMD -1.49 [-2.03, -0.95] Low Downgraded: risk of bias, imprecision 2 studies · 94 participants |
| Systemic melatonin (oral tablets, 6 mg/day for 8 weeks) as an adjunct to NSPT | NSPT plus placebo | Serum IL-6, change from baseline 8 weeks post-treatment · Periodontal clinics (Iran, Romania) | SMD -5.04 [-13.97, 3.89] Low Downgraded: risk of bias, imprecision 2 studies · 94 participants |
| Systemic melatonin (oral tablets, 6 mg/day for 8 weeks) as an adjunct to NSPT | NSPT plus placebo | Serum TAC (total antioxidant capacity), change from baseline 8 weeks post-treatment · Periodontal clinics (Iran, Romania) | SMD 0.08 [-0.05, 0.20] Low Downgraded: risk of bias, imprecision 2 studies · 94 participants |
| Systemic melatonin (oral tablets, 6 mg/day for 8 weeks) as an adjunct to NSPT | NSPT plus placebo | Serum hs-CRP, change from baseline 8 weeks post-treatment · Periodontal clinics (Iran, Romania) | SMD -0.97 [-1.22, -0.73] Low Downgraded: risk of bias, imprecision 2 studies · 94 participants |
| Systemic melatonin (oral tablets, 6 mg/day for 8 weeks) as an adjunct to NSPT | NSPT plus placebo | PPD (probing pocket depth), change from baseline 8 weeks post-treatment · Periodontal clinics (Iran, Romania) | SMD -1.99 [-2.54, -1.43] Low Downgraded: risk of bias, imprecision 2 studies · 94 participants |
| Systemic melatonin (oral tablets, 6 mg/day for 8 weeks) as an adjunct to NSPT | NSPT plus placebo | HbA1c, change from baseline 8 weeks post-treatment · Periodontal clinics (Iran, Romania) | SMD -1.15 [-1.63, -0.68] Low Downgraded: risk of bias, imprecision 2 studies · 94 participants |
| Systemic melatonin (oral tablets, 6 mg/day for 8 weeks) as an adjunct to NSPT | NSPT plus placebo | Serum TNF-alpha, change from baseline 8 weeks post-treatment · Periodontal clinics (Iran, Romania) | SMD -0.51 [-1.92, 0.90] Low Downgraded: risk of bias, imprecision 2 studies · 94 participants |
Included primary studies 3
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Anton 2021 Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and… PMID:33562452 | 2021 | 1 other review | not stated | not extracted yet |
| Bazyar 2019 The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and… PMID:30328031 | 2019 | this review only | not stated | not extracted yet |
| Sarac Gul 2024 Melatonin supports nonsurgical periodontal treatment in patients with Type 2 diabetes mellitus and periodontitis: A randomized clinical… PMID:38055628 | 2024 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Effects of Nutritional Supplements Alone or as an Adjunct to Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis. (2026) | 1 | 0.01 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (18 years or older) with periodontitis and confirmed type 2 diabetes mellitus | Patients with T2DM and periodontitis (n=149 in 3 RCTs; n=94 in 2 pooled RCTs) |
| Intervention | Systemic melatonin as an adjunct to NSPT | Oral melatonin 6 mg/day plus NSPT (n=75) |
| Comparison | NSPT alone or NSPT plus placebo | NSPT plus placebo (2 RCTs) or NSPT alone (1 RCT) (n=74) |
| Outcomes | Primary: clinical periodontal parameters (PPD, CAL, gingival inflammation, plaque). Secondary: biochemical periodontal parameters; systemic glycemic control, oxidative stress and inflammation | PPD, CAL, BoP, GI, PI, GCF MMP-8, RANKL, OPG, HbA1c, FBG, serum TAC, hs-CRP, TNF-alpha, IL-6, IL-1beta, MDA, SOD, CAT, GPx, TOS |
| Study designs | Randomized controlled trials | RCTs (3) |
| Timing | Minimum follow-up of 1.5 months | 8 weeks (pooled); 3 and 6 months (one trial) |