Non-Cochrane · intervention · PM42186652
Clinical Effectiveness of Resin Infiltration and Fluoride Varnish for Managing White Spot Lesions (International Caries Detection and Assessment System (ICDAS) ≤ 2) During Multibracket Orthodontic Treatment: A Systematic Review and Meta-Analysis.
Kosys Vilius, Streimikyte Gabija, Trakiniene Giedre · Cureus · 2026 · PubMed · doi:10.7759/cureus.107633
Findings
Population Patients undergoing fixed multibracket orthodontic treatment with white spot lesions (ICDAS 1-2)
1 finding
| Resin infiltration | Fluoride varnish | Esthetic improvement: color change (delta E) Approximately 6 months or until debonding · Clinical trials in orthodontic patients | MD -3.43 [-4.20, -2.66] Moderate Downgraded: risk of bias, imprecision 2 studies · 51 participants |
Included primary studies 6
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Kashash 2024 Resin infiltration versus fluoride varnish for visual improvement of white spot lesions during multibracket treatment. A… PMID:38733458 | 2024 | 2 other reviews | Esthetic improvement: color change (delta E) | not extracted yet |
| Wierichs 2023 (J Dent) Masking-efficacy and caries arrestment after resin infiltration or fluoridation of initial caries lesions in adolescents during… PMID:37730095 | 2023 | 2 other reviews | Esthetic improvement: color change (delta E) | not extracted yet |
| Kashash 2024 Resin infiltration versus fluoride varnish for visual improvement of white spot lesions during multibracket treatment. A… DOI:10.1007/s00784-024-05695-2 | 2024 | this review only | Esthetic improvement: color change (delta E) | not extracted yet |
| Wierichs 2023 (Eur J Orthod) Short-term efficacy of caries resin infiltration during treatment with orthodontic fixed appliances. A randomized controlled trial. PMID:36200478 | 2023 | this review only | not stated | not extracted yet |
| Wierichs 2023 (short-term, 1 week) Short-term efficacy of caries resin infiltration during treatment with orthodontic fixed appliances. A randomized controlled trial DOI:10.1093/ejo/cjac040 | 2022 | this review only | not stated | not extracted yet |
| Wierichs 2023 (until debonding) Masking-efficacy and caries arrestment after resin infiltration or fluoridation of initial caries lesions in adolescents during… DOI:10.1016/j.jdent.2023.104713 | 2023 | this review only | Esthetic improvement: color change (delta E) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human patients of any sex and ethnicity up to 70 years undergoing fixed multibracket orthodontic treatment with or at risk of enamel WSLs classified ICDAS <= 2 | Orthodontic patients with ICDAS <= 2 WSLs (n=66 across 3 RCTs: 15, 15, 36) |
| Intervention | Resin infiltration | Resin infiltration (n=3 RCTs) |
| Comparison | Fluoride varnish (or placebo) | Fluoride varnish (n=3 RCTs) |
| Outcomes | Esthetic improvement (delta E) primary; lesion regression, ICDAS change, caries activity (QLF, DIAGNOdent), adverse effects | delta E (2 RCTs, pooled); ICDAS, DIAGNOdent, QLF (narrative, 3 RCTs) |
| Study designs | RCTs and controlled clinical trials | RCTs (n=3): two split-mouth, one parallel-group |
| Timing | Not specified | 1 week to about 12 months or until debonding |