Non-Cochrane · prognostic · PM42032726
Impact of root canal treatment timing on the prognosis of autotransplanted teeth with complete root formation: a systematic review and meta-analysis.
Li Shuangting, Chen Jiazhu, Li Shuangjing, et al. · BMC oral health · 2026 · PubMed · doi:10.1186/s12903-026-08413-4
Findings
Population Autotransplanted teeth with complete root formation
38 findings
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth | Pooled proportion (%) 92 [80, 97] GRADE not reported 19 studies · 778 participants |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Fixation analysis: overall | Pooled proportion (%) 84 [65, 93] GRADE not reported 10 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Survival rate of the autotransplanted tooth (tooth present at follow-up) | Pooled proportion (%) 95 [91, 97] GRADE not reported 24 studies · 1473 participants |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Fixation: rigid | Pooled proportion (%) 41 [10, 81] GRADE not reported 3 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Follow-up more than 5 years · Follow-up more than 5 years | Pooled proportion (%) 80 [68, 88] GRADE not reported 3 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Fixation analysis: overall | Pooled proportion (%) 18 [8, 35] GRADE not reported 10 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Follow-up more than 5 years · Follow-up more than 5 years | Pooled proportion (%) 16 [12, 22] GRADE not reported 4 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Follow-up up to 5 years · Follow-up up to 5 years | Pooled proportion (%) 77 [57, 90] GRADE not reported 8 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Survival rate of the autotransplanted tooth (tooth present at follow-up) Study design: prospective cohort studies | Pooled proportion (%) 98 [93, 99] GRADE not reported 11 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Survival rate of the autotransplanted tooth (tooth present at follow-up) Study design: retrospective cohort studies | Pooled proportion (%) 91 [89, 93] GRADE not reported 14 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Fixation: flexible | Pooled proportion (%) 11 [6, 20] GRADE not reported 7 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Follow-up up to 5 years · Follow-up up to 5 years | Pooled proportion (%) 30 [11, 60] GRADE not reported 7 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Follow-up up to 3 years · Follow-up up to 3 years | Pooled proportion (%) 99 [97, 100] GRADE not reported 1 study |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Follow-up up to 3 years · Follow-up up to 3 years | Pooled proportion (%) 6 [1, 22] GRADE not reported 3 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Fixation: rigid | Pooled proportion (%) 88 [66, 96] GRADE not reported 3 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Fixation: flexible | Pooled proportion (%) 81 [52, 94] GRADE not reported 7 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) | Pooled proportion (%) 16 [8, 30] GRADE not reported 16 studies · 833 participants |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Follow-up duration analysis: overall | Pooled proportion (%) 83 [67, 92] GRADE not reported 12 studies |
| Root canal treatment of any timing (all teeth pooled) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Follow-up duration analysis: overall | Pooled proportion (%) 17 [8, 33] GRADE not reported 14 studies |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Tooth type: all (panel total) | Pooled proportion (%) 94 [80, 99] GRADE not reported 9 studies |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Tooth type: canines | Pooled proportion (%) 16 [9, 27] GRADE not reported 3 studies |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth | Pooled proportion (%) 92 [78, 98] GRADE not reported 12 studies · 586 participants |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Tooth type: all (panel total) | Pooled proportion (%) 14 [9, 23] GRADE not reported 8 studies |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Survival rate of the autotransplanted tooth (tooth present at follow-up) | Pooled proportion (%) 95 [89, 98] GRADE not reported 15 studies · 879 participants |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Tooth type: canines | Pooled proportion (%) 92 [68, 98] GRADE not reported 3 studies |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Tooth type: third molars | Pooled proportion (%) 95 [75, 99] GRADE not reported 6 studies |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Tooth type: third molars | Pooled proportion (%) 13 [6, 26] GRADE not reported 5 studies |
| Postoperative prophylactic root canal treatment | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) | Pooled proportion (%) 11 [6, 18] GRADE not reported 11 studies · 671 participants |
| Immediate intraoperative root canal treatment | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Tooth type: canines | Pooled proportion (%) 18 [9, 34] GRADE not reported 2 studies |
| Immediate intraoperative root canal treatment | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) | Pooled proportion (%) 40 [9, 83] GRADE not reported 3 studies · 119 participants |
| Immediate intraoperative root canal treatment | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Tooth type: third molars | Pooled proportion (%) 97 [88, 100] GRADE not reported 1 study |
| Immediate intraoperative root canal treatment | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) Tooth type: third molars | Pooled proportion (%) 86 [75, 94] GRADE not reported 1 study |
| Immediate intraoperative root canal treatment | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth Tooth type: canines | Pooled proportion (%) 96 [11, 100] GRADE not reported 2 studies |
| Immediate intraoperative root canal treatment | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth | Pooled proportion (%) 95 [57, 100] GRADE not reported 3 studies · 129 participants |
| Immediate intraoperative root canal treatment | Not applicable (single-arm pooled proportions) | Survival rate of the autotransplanted tooth (tooth present at follow-up) | Pooled proportion (%) 96 [87, 99] GRADE not reported 3 studies · 129 participants |
| Clinical observation-based root canal treatment (treatment only when symptoms or radiographic signs appear) | Not applicable (single-arm pooled proportions) | Survival rate of the autotransplanted tooth (tooth present at follow-up) | Pooled proportion (%) 93 [91, 95] GRADE not reported 7 studies · 434 participants |
| Clinical observation-based root canal treatment (treatment only when symptoms or radiographic signs appear) | Not applicable (single-arm pooled proportions) | Success rate of the autotransplanted tooth | Pooled proportion (%) 84 [35, 98] GRADE not reported 4 studies · 63 participants |
| Clinical observation-based root canal treatment (treatment only when symptoms or radiographic signs appear) | Not applicable (single-arm pooled proportions) | Root resorption rate (radiographic resorptive signs) | Pooled proportion (%) 40 [5, 89] GRADE not reported 2 studies · 43 participants |
Included primary studies 47
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Arikan 2008 5-year longitudinal study of survival rate and periodontal parameter changes at sites of maxillary canine autotransplantation. PMID:18380551 | 2008 | 1 other review | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Cui 2021 Effect of Root Canal Therapy on the Success Rate of Teeth with Complete Roots in Autogenous Tooth Transplantation. PMID:33936357 | 2021 | 1 other review | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Han 2025 Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China. PMID:39802186 | 2025 | 1 other review | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Watanabe 2010 Long-term observation of autotransplanted teeth with complete root formation in orthodontic patients. PMID:21130330 | 2010 | 1 other review | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Xia 2025 Prognostic factors for autotransplanted third molars with completely formed roots: A retrospective cohort study. PMID:39580736 | 2025 | 1 other review | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Yan 2010 Immediate autotransplantation of mandibular third molar in China. PMID:20452259 | 2010 | 1 other review | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Ahlberg 1983 Long-Term Evaluation of Autotransplanted Maxillary Canines with Completed Root Formation DOI:10.3109/00016358309162300 | 1983 | this review only | not stated | not extracted yet |
| Ahlberg 1983 Long-term evaluation of autotransplanted maxillary canines with completed root formation. PMID:6575571 | 1983 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Akiyama 1998 A clinical and radiographic study of 25 autotransplanted third molars DOI:10.1046/j.1365-2842.1998.00215.x | 1998 | this review only | not stated | not extracted yet |
| Akiyama 1998 A clinical and radiographic study of 25 autotransplanted third molars. PMID:9781869 | 1998 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Andreasen 1970 A clinical and radiographic study of 76 autotransplanted third molars DOI:10.1111/j.1600-0722.1970.tb02104.x | 1970 | this review only | not stated | not extracted yet |
| Andreasen 1970 A clinical and radiographic study of 76 autotransplanted third molars. PMID:5275523 | 1970 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Aoyama 2012 Prognostic factors for autotransplantation of teeth with complete root formation DOI:10.1016/j.oooo.2011.09.037 | 2012 | this review only | not stated | not extracted yet |
| Aoyama 2012 Prognostic factors for autotransplantation of teeth with complete root formation. PMID:22705233 | 2012 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Arikan 2008 5‐Year Longitudinal Study of Survival Rate and Periodontal Parameter Changes at Sites of Maxillary Canine Autotransplantation DOI:10.1902/jop.2008.070409 | 2008 | this review only | not stated | not extracted yet |
| Azaz (Badri) 1978 Clinical and roentgenographic evaluation of thirty-seven autotransplanted impacted maxillary canines DOI:10.1016/0030-4220(78)90216-5 | 1978 | this review only | not stated | not extracted yet |
| Azaz 1978 Clinical and roentgenographic evaluation of thirty-seven autotransplanted impacted maxillary canines. PMID:271292 | 1978 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Cui 2021 Effect of Root Canal Therapy on the Success Rate of Teeth with Complete Roots in Autogenous Tooth Transplantation DOI:10.1155/2021/6675604 | 2021 | this review only | not stated | not extracted yet |
| Ferreira 2011 Autogenous tooth transplantation: Evaluation of pulp tissue regeneration DOI:10.4317/medoral.16926 | 2011 | this review only | not stated | not extracted yet |
| Heslop 1967 Autogenous replantation of the maxillary canine DOI:10.1016/s0007-117x(67)80038-6 | 1967 | this review only | not stated | not extracted yet |
| Heslop 1967 Autogenous replantation of the maxillary canine. PMID:5235085 | 1967 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Hwang 2022 Rapid prototyping-assisted tooth autotransplantation is associated with a reduced root canal treatment rate: a retrospective cohort study DOI:10.1186/s12903-022-02058-9 | 2022 | this review only | not stated | not extracted yet |
| Hwang 2022 Rapid prototyping-assisted tooth autotransplantation is associated with a reduced root canal treatment rate: a retrospective cohort study. PMID:35105368 | 2022 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Jakobsen 2018 Autotransplantation of premolars: does surgeon experience matter? DOI:10.1016/j.ijom.2018.08.003 | 2018 | this review only | not stated | not extracted yet |
| Jakobsen 2018 Autotransplantation of premolars: does surgeon experience matter? PMID:30170776 | 2018 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Jonsson 2004 Autotransplantation of premolars to premolar sites. A long-term follow-up study of 40 consecutive patients DOI:10.1016/j.ajodo.2003.12.002 | 2004 | this review only | not stated | not extracted yet |
| Jonsson 2004 Autotransplantation of premolars to premolar sites. A long-term follow-up study of 40 consecutive patients. PMID:15179391 | 2004 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Kristerson (Eur J Orthod) 1991 Autotransplantation of teeth in cases with agenesis or traumatic loss of maxillary incisors DOI:10.1093/ejo/13.6.486 | 1991 | this review only | not stated | not extracted yet |
| Kristerson (J Clin Periodontol) 1991 Autotransplantation of third molars as treatment in advanced periodontal disease DOI:10.1111/j.1600-051x.1991.tb00084.x | 1991 | this review only | not stated | not extracted yet |
| Kristerson 1991 (Eur J Orthod) Autotransplantation of teeth in cases with agenesis or traumatic loss of maxillary incisors. PMID:1817075 | 1991 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Kristerson 1991 (J Clin Periodontol) Autotransplantation of third molars as treatment in advanced periodontal disease. PMID:1894746 | 1991 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Krupp 2024 Survival of retained permanent canines after autotransplantation: A retrospective cohort study DOI:10.1016/j.ajodo.2023.11.011 | 2024 | this review only | not stated | not extracted yet |
| Krupp 2024 Survival of retained permanent canines after autotransplantation: A retrospective cohort study. PMID:38340133 | 2024 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Marques-Ferreira 2011 Autogenous tooth transplantation: evaluation of pulp tissue regeneration. PMID:21743431 | 2011 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Nethander 1998 Autogenous free tooth transplantation by the two-stage operation technique: An analysis of treatment factors DOI:10.1080/00016359850136085 | 1998 | this review only | not stated | not extracted yet |
| Nethander 1998 Autogenous free tooth transplantation by the two-stage operation technique. An analysis of treatment factors. PMID:9669463 | 1998 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Sagne 1986 Transalveolar transplantation of maxillary canines an alternative to orthodontic treatment in adult patients DOI:10.1016/0889-5406(86)90047-8 | 1986 | this review only | not stated | not extracted yet |
| Sagne 1986 Transalveolar transplantation of maxillary canines. An alternative to orthodontic treatment in adult patients. PMID:3461707 | 1986 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Schatz 1993 A clinical and radiologic study of autotransplanted impacted canines DOI:10.1016/s0901-5027(05)80663-0 | 1993 | this review only | not stated | not extracted yet |
| Schatz 1993 A clinical and radiologic study of autotransplanted impacted canines. PMID:8106807 | 1993 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Tanaka 2008 Autotransplantation of 28 Premolar Donor Teeth in 24 Orthodontic Patients DOI:10.2319/120706-495.1 | 2008 | this review only | not stated | not extracted yet |
| Tanaka 2008 Autotransplantation of 28 premolar donor teeth in 24 orthodontic patients. PMID:18193971 | 2008 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Thomsson 1984 A clinical and radiographic evaluation of cultivated and autotransplanted human teeth DOI:10.1016/s0300-9785(84)80006-x | 1984 | this review only | not stated | not extracted yet |
| Thomsson 1984 A clinical and radiographic evaluation of cultivated and autotransplanted human teeth. PMID:6430828 | 1984 | this review only | Survival rate of the autotransplanted tooth (tooth present at follow-up) | not extracted yet |
| Watanabe 2010 Long-term observation of autotransplanted teeth with complete root formation in orthodontic patients DOI:10.1016/j.ajodo.2009.03.043 | 2010 | this review only | not stated | not extracted yet |
| Xia 2025 Prognostic factors for autotransplanted third molars with completely formed roots DOI:10.1016/j.adaj.2024.10.004 | 2025 | this review only | not stated | not extracted yet |
| Yan 2010 Immediate autotransplantation of mandibular third molar in China DOI:10.1016/j.tripleo.2010.02.026 | 2010 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Clinical outcomes of tooth autotransplantation: a systematic review and meta-analysis of survival. (2026) | 6 | 0.07 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients who underwent any type of autologous tooth transplantation; teeth with complete root formation | Autotransplanted teeth with complete root formation (n=1473 teeth) |
| Intervention | Different timings of root canal treatment on autotransplanted teeth with complete root formation | Postoperative prophylactic RCT (n=879 teeth, 15 studies); intraoperative immediate RCT (n=129, 3 studies); clinical observation-based RCT (n=434, 7 studies) |
| Comparison | Indirect or concurrent comparison of different RCT timings | No direct comparison; indirect between-group comparisons only |
| Outcomes | Survival rate (primary); success rate and root resorption (secondary) | Survival rate (24 studies); success rate (19 studies, 778 teeth); root resorption (16 studies, 833 teeth) |
| Study designs | Primary human studies reporting or allowing inference of survival, success and root resorption; English language | 24 non-controlled cohort studies (12 prospective, 12 retrospective), 1967 to 2025, 11 countries |
| Timing | Not specified | Follow-up from 6 months to about 22 years |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | NR | Yes | no |
| 2Protocol established before the reviewcritical | NR | Partial Yes | no |
| 3Choice of study designs explained | NR | No | no |
| 4Comprehensive literature searchcritical | NR | Partial Yes | no |
| 5Study selection in duplicate | NR | Yes | no |
| 6Data extraction in duplicate | NR | Yes | no |
| 7List of excluded studies with reasonscritical | NR | No | no |
| 8Included studies described in detail | NR | Partial Yes | no |
| 9Risk of bias assessed satisfactorilycritical | NR | RCT: N/A · NRSI: Partial Yes | no |
| 10Funding of included studies reported | NR | No | no |
| 11Appropriate meta-analysis methodscritical | NR | RCT: N/A · NRSI: Yes | no |
| 12Impact of risk of bias on the pooled results | NR | No | no |
| 13Risk of bias accounted for in interpretationcritical | NR | Yes | no |
| 14Heterogeneity explained | NR | Yes | no |
| 15Publication bias investigatedcritical | NR | No | no |
| 16Conflicts of interest reported | NR | Yes | no |
| Overall | NR | Critically Low | no |