Non-Cochrane · aetiology · PM42001252
Association between periodontitis and oral health-related quality of life in patients with systemic conditions: A meta-analysis.
Bortolaso Rafael Vargas, Del' Agnese Catiusse Crestani, Oliveira Leandro Machado, et al. · Journal of periodontology · 2026 · PubMed · doi:10.1002/jper.70130
Findings
Population Adults (18 years or older) with systemic conditions
16 findings
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Study quality (NOS): Low (9 data sets) | SMD 0.51 [-0.15, 1.18] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Geographic location: Europe (11 data sets) | SMD 0.38 [-0.13, 0.89] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Comorbidity: Rheumatoid arthritis or ankylosing spondylitis (4 data sets) | SMD 0.01 [-0.44, 0.46] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | Negative impact on OHRQoL (binary, adjusted) Cross-sectional · Overall | OR 2.53 [1.08, 5.89] Very low Downgraded: imprecision, inconsistency 3 studies · 505 participants |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Comorbidity: Leukemia (2 data sets) | SMD -0.39 [-1.24, 0.46] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Comorbidity: Transplantation (3 data sets) | SMD 0.25 [-0.69, 1.18] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, OHIP-14 total score (0 to 56) Cross-sectional · Overall | MD 2.29 [0.24, 4.33] Very low Downgraded: risk of bias, inconsistency 15 studies · 1377 participants |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Comorbidity: Psoriasis (2 data sets) | SMD 0.70 [0.39, 1.01] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Study quality (NOS): Moderate (10 data sets) | SMD 0.19 [-0.08, 0.45] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Geographic location: Asia (2 data sets) | SMD 0.18 [-0.54, 0.90] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Comorbidity: Diabetes or cardiovascular disease (5 data sets) | SMD 0.43 [-0.69, 1.56] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Comorbidity: End-stage renal or liver diseases (3 data sets) | SMD 0.47 [-0.16, 1.11] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Geographic location: Latin America (6 data sets) | SMD 0.28 [-0.09, 0.65] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Periodontitis diagnosis: 2017 EFP/AAP classification (4 data sets) | SMD 0.83 [0.18, 1.47] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Periodontitis diagnosis: Earlier criteria (15 data sets) | SMD 0.10 [-0.08, 0.29] GRADE not reported Studies not reported |
| Periodontitis (clinical periodontal examination) | No periodontitis or milder forms of periodontitis | OHRQoL, all instruments (continuous) Cross-sectional · Overall | SMD 0.31 [0.03, 0.59] Very low Downgraded: risk of bias, imprecision 16 studies · 1672 participants |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Oliveira 2020 Periodontitis is associated with oral health‐related quality of life in individuals with end‐stage renal disease DOI:10.1111/jcpe.13233 | 2020 | 1 other review | OHRQoL, all instruments (continuous) | not extracted yet |
| Angst 2020 Association between oral health-related quality of life and periodontal status in patients with leukemia DOI:10.1111/idj.12576 | 2020 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Costa 2021 Periodontitis and the impact of oral health on the quality of life of psoriatic individuals: a case-control study DOI:10.1007/s00784-020-03600-1 | 2020 | this review only | OHRQoL, all instruments (continuous); Negative impact on OHRQoL (binary, adjusted) | not extracted yet |
| Drumond-Santana 2007 Impacto da doença periodontal na qualidade de vida de indivíduos diabéticos dentados DOI:10.1590/s0102-311x2007000300022 | 2007 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Falcón-Flores 2024 [Impact of self-reported periodontal status on oral health-related quality of life in adult population with Type 2 Diabetes from Mexico… PMID:38516881 | 2024 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Han 2020 Impact of periodontitis on quality of life among subjects with rheumatoid arthritis: a cross sectional study DOI:10.1186/s12903-020-01275-4 | 2020 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Kabisch 2022 Periodontitis, age-related diseases and diabetes in an endocrinological outpatient setting (PARADIES): a cross-sectional analysis on… DOI:10.1007/s00592-021-01838-z | 2022 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Lazureanu 2022 The Influence of Periodontal Disease on Oral Health Quality of Life in Patients with Cardiovascular Disease: A Cross-Sectional… PMID:35630001 | 2022 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Mishra 2024 Impact of periodontitis on oral health‐related quality of life of patients with psoriatic arthritis DOI:10.1111/scd.12938 | 2023 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Mühlberg 2017 Oral health-related quality of life depending on oral health in patients with rheumatoid arthritis DOI:10.1007/s00784-017-2068-4 | 2017 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Posada-López 2023 Oral health-related quality of life in a group of patients with rheumatoid arthritis DOI:10.17219/dmp/149455 | 2023 | this review only | OHRQoL, all instruments (continuous); Negative impact on OHRQoL (binary, adjusted) | not extracted yet |
| Schmalz 2016 Oral health‐related quality of life in patients on chronic haemodialysis and after kidney transplantation DOI:10.1111/odi.12519 | 2016 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Schmalz 2018a Oral health-related quality of life is associated with disease specific parameters in patients with ankylosing spondylitis DOI:10.1007/s00784-018-2375-4 | 2018 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Schmalz 2018b Oral health related quality of life depending on oral health and specific factors in patients after lung transplantation DOI:10.1111/crj.12625 | 2017 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Schmalz 2018c Oral health-related quality of life depending on dental and periodontal health in different patients before and after liver transplantation DOI:10.1007/s00784-017-2298-5 | 2017 | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Schmalz 2020 DOI:10.3290/j.ohpd.a44685 | NR | this review only | OHRQoL, all instruments (continuous) | not extracted yet |
| Sousa 2019 Evaluation of oral health-related quality of life in individuals with type 2 diabetes mellitus DOI:10.20396/bjos.v18i0.8655466 | 2019 | this review only | Negative impact on OHRQoL (binary, adjusted) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Influence of periodontal conditions on quality of life in patients with chronic kidney disease: A systematic review and meta-analysis. (2026) | 1 | 0.03 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (18 years or older) with systemic conditions or diseases | Adults with systemic conditions: diabetes, cardiovascular disease, rheumatoid arthritis, psoriasis, leukemia, end-stage renal or liver disease, transplantation (n=17 studies) |
| Intervention | Exposure: periodontitis or severe periodontitis diagnosed by PPD and/or CAL | Periodontitis (Page and Eke, Eke et al. 2012, 2017 EFP/AAP and other definitions) |
| Comparison | Absence of periodontitis or milder forms of periodontitis | No periodontitis or no/mild periodontitis |
| Outcomes | OHRQoL measured with validated instruments | OHRQoL: OHIP-14 (n=16 studies), OIDP (n=1 study); continuous (n=16) and binary adjusted OR (n=3) |
| Study designs | Observational studies (longitudinal, case-control, cross-sectional) | 16 cross-sectional studies and 1 case-control study (analyzed as cross-sectional) |
| Timing | Not specified | Not specified |