Non-Cochrane · intervention · PM41950291
The impact of physical adjunctive interventions on outcomes of clear aligner treatment: A systematic review of randomized controlled trials.
Sirri Mohamad Radwan, Namera Mohammad Osama, Salahi Alasbahi Mohamad Yaman · PloS one · 2026 · PubMed · doi:10.1371/journal.pone.0346566
Findings
Population Healthy individuals undergoing clear aligner treatment
2 findings
| AcceleDent vibration device plus clear aligners | Clear aligners with sham device | Little's Irregularity Index, mandible Alignment stage · Orthodontic clinics · mandible | MD 0.44 [-0.80, 1.69] Very low Downgraded: risk of bias, imprecision, inconsistency 2 studies · 48 participants |
| AcceleDent vibration device plus clear aligners | Clear aligners with sham device | Little's Irregularity Index, maxilla Alignment stage · Orthodontic clinics · maxilla | MD 0.08 [-0.86, 1.02] Very low Downgraded: risk of bias, imprecision, inconsistency 2 studies · 49 participants |
Included primary studies 10
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Katchooi 2018 Effect of supplemental vibration on orthodontic treatment with aligners: A randomized trial. PMID:29501108 | 2018 | 2 other reviews | Little's Irregularity Index, maxilla; Little's Irregularity Index, mandible | not extracted yet |
| Alansari 2018 The effects of brief daily vibration on clear aligner orthodontic treatment DOI:10.1016/j.ejwf.2018.10.002 | 2018 | 1 other review | not stated | not extracted yet |
| Bragassa 2018 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Katchooi 2018 Effect of supplemental vibration on orthodontic treatment with aligners: A randomized trial DOI:10.1016/j.ajodo.2017.10.017 | 2018 | 1 other review | not stated | not extracted yet |
| Lombardo 2019 Does low-frequency vibration have an effect on aligner treatment? A single-centre, randomized controlled trial DOI:10.1093/ejo/cjy076 | 2018 | 1 other review | not stated | not extracted yet |
| Lombardo 2019 Does low-frequency vibration have an effect on aligner treatment? A single-centre, randomized controlled trial. PMID:30423130 | 2019 | 1 other review | not stated | not extracted yet |
| Pescheret 2017 matched by author and year (probable) | NR | 1 other review | Little's Irregularity Index, maxilla; Little's Irregularity Index, mandible | not extracted yet |
| Caccianiga 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Idarraga 2023 Randomized clinical trial on the effect of intermittent vibrational force application during orthodontic treatment with aligners on RANKL… PMID:37206229 | 2023 | this review only | not stated | not extracted yet |
| Perez Idarraga 2023 Randomized clinical trial on the effect of intermittent vibrational force application during orthodontic treatment with aligners on… DOI:10.1002/btm2.10491 | 2023 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Healthy individuals of any age undergoing clear aligner therapy | Clear aligner patients, 266 participants (n=7) |
| Intervention | Nonsurgical physical adjuncts (vibration, low-level laser/photobiomodulation, bioelectrical stimulation) | AcceleDent and VPro5 vibration devices (n=6); low-level laser therapy (n=1) |
| Comparison | Clear aligner treatment without acceleration adjunct or with sham | Sham device or aligners alone (n=7) |
| Outcomes | Total treatment time, Little's Irregularity Index, PCPDI reduction, tracking accuracy, pain, OHRQoL, biomarkers, periodontal indices, root resorption | Tooth-movement metrics, process/operational success, compliance, patient-reported outcomes, biomarkers, periodontal indices (n=7) |
| Study designs | Human RCTs (parallel or split-mouth) | RCTs, parallel-group (n=7) |
| Timing | Not specified | Leveling and alignment stage; follow-up 20 days to 12 months |