Non-Cochrane · prognostic · PM41859028
Role of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker.
Patil Gauri Vilas, Mahendra Jaideep, Ponnaiyan Deepa, et al. · Medicine international · 2026 · PubMed · doi:10.3892/mi.2026.307
Findings
Population Individuals with periodontitis and periodontally healthy controls
4 findings
| Lactoferrin concentration (ELISA) in saliva, serum or gingival crevicular fluid as a biomarker | Periodontally healthy controls | Association of lactoferrin with clinical attachment loss Saliva, serum and GCF samples; random-effects model | OR 49.430 [19.855, 123.053] GRADE not reported 15 studies · 798 participants |
| Lactoferrin concentration (ELISA) in saliva, serum or gingival crevicular fluid as a biomarker | Periodontally healthy controls | Lactoferrin concentration in periodontitis versus healthy controls Saliva, serum and GCF samples; random-effects model | OR 3.960 [1.140, 11.180] GRADE not reported 15 studies · 798 participants |
| Lactoferrin concentration (ELISA) in saliva, serum or gingival crevicular fluid as a biomarker | Periodontally healthy controls | Association of lactoferrin with probing pocket depth Saliva, serum and GCF samples; random-effects model | OR 39.270 [17.070, 90.340] GRADE not reported 15 studies · 798 participants |
| Lactoferrin concentration (ELISA) in saliva, serum or gingival crevicular fluid as a biomarker | Periodontally healthy controls | Association of lactoferrin with gingival index Saliva, serum and GCF samples; random-effects model | OR 7.173 [2.914, 17.654] GRADE not reported 15 studies · 798 participants |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Glimvall 2012 Elevated levels of salivary lactoferrin, a marker for chronic periodontitis? PMID:22471324 | 2012 | 1 other review | not stated | not extracted yet |
| Ramenzoni 2021 Origin of MMP-8 and Lactoferrin levels from gingival crevicular fluid, salivary glands and whole saliva. PMID:34353321 | 2021 | 1 other review | not stated | not extracted yet |
| Tsai 1998 Gingival crevicular fluid lactoferrin levels in adult periodontitis patients. PMID:9583225 | 1998 | 1 other review | not stated | not extracted yet |
| Wei 2004 The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1beta in gingival crevicular fluid: implications… PMID:15324348 | 2004 | 1 other review | not stated | not extracted yet |
| Wu 2009 Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and… PMID:19453860 | 2009 | 1 other review | not stated | not extracted yet |
| Yadav 2014 Effect of periodontal therapy on lactoferrin levels in gingival crevicular fluid. PMID:24913177 | 2014 | 1 other review | not stated | not extracted yet |
| Adonogianaki 1993 Lactoferrin in the gingival crevice as a marker of polymorphonuclear leucocytes in periodontal diseases. PMID:8421112 | 1993 | this review only | not stated | not extracted yet |
| Figueredo 1999 Increased interleukin-1beta concentration in gingival crevicular fluid as a characteristic of periodontitis. PMID:10632521 | 1999 | this review only | not stated | not extracted yet |
| Figueredo 2000 Increased amounts of laminin in GCF from untreated patients with periodontitis. PMID:10847534 | 2000 | this review only | not stated | not extracted yet |
| Mandra 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mandra 2018 [Diagnosis of small tumors of the auditory meatus by contrast cisternography]. PMID:462019 | 1979 | this review only | not stated | not extracted yet |
| Murray 1995 The relationship between elastase and lactoferrin in healthy, gingivitis and periodontitis sites. PMID:8705815 | 1995 | this review only | not stated | not extracted yet |
| Orhue 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Orhue 2022 Fermentation profiles of Manzanilla-Aloreña cracked green table olives in different chloride salt mixtures. PMID:20227606 | 2010 | this review only | not stated | not extracted yet |
| Shimizu 2011 Effects of orally administered lactoferrin and lactoperoxidase-containing tablets on clinical and bacteriological profiles in chronic… PMID:21747858 | 2011 | this review only | not stated | not extracted yet |
| Talib 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Vozna 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| The role of salivary lactoferrin as a potential biomarker for periodontal disease: a systematic review and meta-analysis. (2026) | 6 | 0.14 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human participants with periodontitis | 496 patients with periodontitis and 302 healthy controls (n=798) |
| Intervention | Periodontitis (exposure); lactoferrin as biomarker | Periodontitis (15 studies) |
| Comparison | Periodontally healthy controls | Healthy controls (n=302) |
| Outcomes | Lactoferrin concentration in saliva, serum or GCF (ELISA); association with PPD, CAL and GI | Lactoferrin concentration (saliva, serum, GCF); PPD; CAL; GI |
| Study designs | Case-control, cross-sectional, RCT and non-randomized controlled trials using ELISA | 9 case-control, 4 cross-sectional, 1 non-randomized interventional, 1 RCT |
| Timing | Not specified | Not specified |