Non-Cochrane · intervention · PM41841054
The Effect of Platelet-Rich Fibrin in Preventing Alveolar Osteitis Following Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis.
Brar Gursimrat, Sodhi Asmita, Brar Gurmeet Singh, et al. · Cureus · 2026 · PubMed · doi:10.7759/cureus.103522
Findings
Population Patients undergoing surgical extraction of mandibular third molars without alveolar osteitis at baseline
1 finding
| Platelet-rich fibrin placed in the extraction socket immediately after tooth removal | No PRF, empty socket or conventional postoperative care | Incidence of alveolar osteitis Third to seventh postoperative day · Mandibular third molar surgery | RR 0.33 [0.20, 0.55] 100 per 1,000 vs 33 per 1,000 Moderate Downgraded: risk of bias, imprecision 7 studies · 776 participants |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Asutay 2017 An evaluation of effects of platelet-rich-fibrin on postoperative morbidities after lower third molar surgery. PMID:29378982 | 2017 | 1 other review | Incidence of alveolar osteitis | not extracted yet |
| Daugela 2018 Influence of leukocyte- and platelet-rich fibrin (L-PRF) on the outcomes of impacted mandibular third molar removal surgery: A split-mouth… PMID:29629438 | 2018 | 1 other review | Incidence of alveolar osteitis | not extracted yet |
| Eshghpour 2014 Effect of platelet-rich fibrin on frequency of alveolar osteitis following mandibular third molar surgery: a double-blinded randomized… PMID:25037182 | 2014 | 1 other review | Incidence of alveolar osteitis | not extracted yet |
| Iqbal 2023 Assessment of Dry Socket after Mandibular Third Molar Surgery Using Platelet-Rich Fibrin - A Prospective Clinical Study. PMID:37190682 | 2023 | 1 other review | Incidence of alveolar osteitis | not extracted yet |
| Unsal 2018 Evaluation of the Effect of Platelet-Rich Fibrin on the Alveolar Osteitis Incidence and Periodontal Probing Depth after Extracting… PMID:29465055 | 2018 | 1 other review | Incidence of alveolar osteitis | not extracted yet |
| Al-Hamed 2017 matched by author and year (probable) | NR | this review only | Incidence of alveolar osteitis | not extracted yet |
| Asif 2023 Comparative Study of Frequency of Alveolar Osteitis, with and without using Platelet-Rich Fibrin in Mandibular Third Molar Surgery. PMID:37033125 | 2023 | this review only | Incidence of alveolar osteitis | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Efficacy and Safety of Regenerative Periodontal Therapy on Recovery After Surgical Removal of Impacted Third Molars: A Systematic Review… (2026) | 5 | 0.15 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients undergoing surgical extraction of mandibular third molars with no clinical diagnosis of AO at baseline | Mandibular third molar extraction sites (776 sites: 388 PRF, 388 control) |
| Intervention | PRF placed in the extraction socket immediately after tooth removal | PRF with centrifugation 2,700 to 3,000 rpm for 10 to 12 minutes (n=7) |
| Comparison | No PRF, empty socket, or conventional postoperative care without platelet concentrate | No PRF or conventional extraction care (n=7) |
| Outcomes | Incidence of AO (pain with partial or complete clot loss and exposed bone within 1 to 7 days); secondary: pain, soft tissue healing, swelling, trismus, probing depth | Incidence of AO (n=7); secondary outcomes not pooled |
| Study designs | RCTs and prospective controlled clinical studies with comparative design | 7 RCTs (4 parallel-group, 3 split-mouth) |
| Timing | 1 to 7 days after extraction | Third or seventh postoperative day |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | No | No | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes | NRSI: N/A · RCT: Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes | NRSI: N/A · RCT: Yes | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |