evidencegaps
Primary study · included by 2 reviews

Influence of leukocyte- and platelet-rich fibrin (L-PRF) on the outcomes of impacted mandibular third molar removal surgery: A split-mouth randomized clinical trial.

Daugela 2018 · Daugela Povilas, Grimuta Vaidas, Sakavicius Dalius, et al. · Quintessence international (Berlin, Germany : 1985) · 2018

Included by

Efficacy and Safety of Regenerative Periodontal Therapy on Recovery After Surgical Removal of Impacted Third Molars: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Daugela 2018 · Table 1; References
Outcome this study informsPooled effectEvidenceCertainty
Adverse events
Regenerative periodontal therapy (any modality) vs Conventional treatment or spontaneous healing
OR 0.64 [0.34, 1.19]22 studiesModerate
The Effect of Platelet-Rich Fibrin in Preventing Alveolar Osteitis Following Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Daugela 2018 · Table 2; Figure 3; reference list
Outcome this study informsPooled effectEvidenceCertainty
Incidence of alveolar osteitis
Platelet-rich fibrin placed in the extraction socket immediately after tooth removal vs No PRF, empty socket or conventional postoperative care · Third to seventh postoperative day
RR 0.33 [0.20, 0.55]7 studies · 776 participantsModerate

2 including reviews in total.