Non-Cochrane · intervention · PM41755378
To do or not to do extraction in temporomandibular joint pain: a systematic review background and rationale.
Aggarwal Pratish, Bhagat Bhushan, Ambildhok Kadambari, et al. · Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2026 · PubMed · doi:10.5125/jkaoms.2026.52.1.3
Findings
Population Patients undergoing or with a history of dental extraction, mainly third molar extraction, including patients with temporomandibular disorders
1 finding
| Dental extraction (predominantly third molar extraction) | Non-extraction, pre-extraction baseline or non-extraction controls | TMJ pain or TMD symptoms (presence or persistence, coded so that values below 1 favor extraction) Variable (baseline only to 6 years follow-up) | RR/OR 0.49 [0.31, 0.66] GRADE not reported 6 studies |
Included primary studies 8
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Barbosa 2021 Are oral overuse behaviours associated with painful temporomandibular disorders? A cross-sectional study in Portuguese university students. PMID:34273189 | 2021 | this review only | TMJ pain or TMD symptoms (presence or persistence, coded so that values below 1 favor extraction) | not extracted yet |
| Damasceno 2020 (systematic review) Is the extraction of third molars a risk factor for the temporomandibular disorders? A systematic review. PMID:32776170 | 2020 | this review only | not stated | not extracted yet |
| DeAngelis 2009 Temporomandibular joint disorders in patients referred for third molar extraction. PMID:20415930 | 2009 | this review only | not stated | not extracted yet |
| Gururaj 2023 The Role of Supraerupted and Distoverted Maxillary Third Molars in the Treatment of Temporomandibular Disorder: A Randomised Controlled… PMID:37525765 | 2023 | this review only | TMJ pain or TMD symptoms (presence or persistence, coded so that values below 1 favor extraction) | not extracted yet |
| Huang 2008 Age and third molar extraction as risk factors for temporomandibular disorder. PMID:18296615 | 2008 | this review only | TMJ pain or TMD symptoms (presence or persistence, coded so that values below 1 favor extraction) | not extracted yet |
| Huang and Rue 2006 Third-molar extraction as a risk factor for temporomandibular disorder. PMID:17082281 | 2006 | this review only | TMJ pain or TMD symptoms (presence or persistence, coded so that values below 1 favor extraction) | not extracted yet |
| Munawar 2016 The Incidence of Signs and Symptoms of Temporomandibular Disorders Following Third Molar Surgery DOI:10.22452/adum.vol23no1.4 | 2016 | this review only | TMJ pain or TMD symptoms (presence or persistence, coded so that values below 1 favor extraction) | not extracted yet |
| Uppgaard 2024 Occurrence and Predictors of Postoperative Preauricular and Masticatory Muscle Pain Symptoms After Surgical Removal of Third Molars: A… PMID:37898152 | 2024 | this review only | TMJ pain or TMD symptoms (presence or persistence, coded so that values below 1 favor extraction) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Humans with clinically diagnosed TMD | Young to middle-aged adults with TMD or referred for third molar surgery; university students; large insurance cohorts (n=42 to over 34,000) |
| Intervention | Third molar or other dental extraction | Third molar extraction (6 studies), therapeutic extraction of supraerupted maxillary third molars (1 study) |
| Comparison | No extraction, pre-extraction baseline or non-extraction controls | Non-extracted individuals or no surgical intervention |
| Outcomes | TMJ pain, function, patient-reported quality of life | TMJ pain, TMD incidence, function, patient-reported outcomes |
| Study designs | Human comparative studies; case reports and case series excluded | 2 RCTs, 1 prospective cohort, 2 retrospective or matched cohorts, 2 cross-sectional studies, 1 systematic review (n=8) |
| Timing | Not specified | Baseline only to 6 years |