Non-Cochrane · aetiology · PM41624667
Low bone density and periodontal disease in postmenopausal women: A systematic review and meta-analysis.
Joseph Betsy, Thomas Julie T, Porwal Priyanka, et al. · Journal of family medicine and primary care · 2025 · PubMed · doi:10.4103/jfmpc.jfmpc_1595_24
Findings
Population Postmenopausal women (peri- and postmenopausal, aged 45 years and above)
5 findings
| Low bone mineral density / osteoporosis (DEXA, WHO T-score < -2.5) (exposure) | Normal bone mineral density controls | Periodontitis severity: clinical attachment loss (CAL, mm) Community and clinic based postmenopausal women | SMD 0.75 [0.22, 1.28] GRADE not reported 6 studies · 1072 participants |
| Low bone mineral density / osteoporosis (DEXA, WHO T-score < -2.5) (exposure) | Normal bone mineral density controls | Periodontitis severity: clinical attachment loss (CAL, mm) Community and clinic based postmenopausal women · Sensitivity analysis excluding high risk of bias studies | SMD 0.92 [0.24, 1.6] GRADE not reported 4 studies · 932 participants |
| Low bone mineral density / osteoporosis (DEXA, WHO T-score < -2.5) (exposure) | Normal bone mineral density controls | Bone mineral density (BMD) Community and clinic based postmenopausal women | SMD -0.64 [-3.01, 1.73] GRADE not reported 5 studies · 912 participants |
| Low bone mineral density / osteoporosis (DEXA, WHO T-score < -2.5) (exposure) | Normal bone mineral density controls | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) Community and clinic based postmenopausal women · GRADE evidence profile estimate | OR 2.52 226 [-1000, 1000] more per 1,000 Low Downgraded: inconsistency 17 studies · 3689 participants |
| Low bone mineral density / osteoporosis (DEXA, WHO T-score < -2.5) (exposure) | Normal bone mineral density controls | Bone mineral density (BMD) Community and clinic based postmenopausal women · Sensitivity analysis | SMD -0.49 [-3.42, 2.45] GRADE not reported 3 studies · 772 participants |
Included primary studies 33
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ayed 2019 Evaluating the possible association between systemic osteoporosis and periodontal disease progression in postmenopausal women DOI:10.1016/j.disamonth.2018.11.001 | 2019 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) | not extracted yet |
| Ayed 2019 Evaluating the possible association between systemic osteoporosis and periodontal disease progression in postmenopausal women. PMID:30502098 | 2019 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) | not extracted yet |
| Darcey 2013 An observational study to assess the association between osteoporosis and periodontal disease DOI:10.1038/sj.bdj.2013.1191 | 2013 | this review only | not stated | not extracted yet |
| Darcey 2013 An observational study to assess the association between osteoporosis and periodontal disease. PMID:24357765 | 2013 | this review only | not stated | not extracted yet |
| Gil-Montoya 2021 Association between low bone mineral density and periodontitis in generally healthy perimenopausal women DOI:10.1002/jper.20-0029 | 2020 | this review only | Bone mineral density (BMD) | not extracted yet |
| Gil-Montoya 2021 Association between low bone mineral density and periodontitis in generally healthy perimenopausal women. PMID:32716051 | 2021 | this review only | Bone mineral density (BMD) | not extracted yet |
| Gondim 2013 Severe Loss of Clinical Attachment Level: An Independent Association With Low Hip Bone Mineral Density in Postmenopausal Females DOI:10.1902/jop.2012.120090 | 2013 | this review only | not stated | not extracted yet |
| Gondim 2013 Severe loss of clinical attachment level: an independent association with low hip bone mineral density in postmenopausal females. PMID:22548585 | 2013 | this review only | not stated | not extracted yet |
| Iwasaki 2013 Association Between Low Bone Mineral Density and Clinical Attachment Loss in Japanese Postmenopausal Females DOI:10.1902/jop.2013.120613 | 2013 | this review only | Bone mineral density (BMD) | not extracted yet |
| Iwasaki 2013 Association between low bone mineral density and clinical attachment loss in Japanese postmenopausal females. PMID:23451986 | 2013 | this review only | Bone mineral density (BMD) | not extracted yet |
| Juluri 2015 Photovoltaic universal joints: ball-and-socket interfaces in molecular photovoltaic cells. PMID:20157914 | 2010 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio); Bone mineral density (BMD) | not extracted yet |
| Juluri 2015 Association of Postmenopausal Osteoporosis and Periodontal Disease: A Double-Blind Case-Control Study. PMID:26435630 | 2015 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio); Bone mineral density (BMD) | not extracted yet |
| Marjanovic 2013 Do patients with osteoporosis have an increased prevalence of periodontal disease? A cross-sectional study DOI:10.1007/s00198-012-2246-9 | 2013 | this review only | Bone mineral density (BMD) | not extracted yet |
| Marjanovic 2013 Do patients with osteoporosis have an increased prevalence of periodontal disease? A cross-sectional study. PMID:23340948 | 2013 | this review only | Bone mineral density (BMD) | not extracted yet |
| Mashalkar 2018 A Cross-Sectional Study to Assess and Correlate Osteoporosis and Periodontitis among Postmenopausal Women: A Dual Energy X-Ray… PMID:29628721 | 2018 | this review only | not stated | not extracted yet |
| Moeintaghavi 2013 matched by author and year (probable) | NR | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio); Bone mineral density (BMD) | not extracted yet |
| Moeintaghavi 2013 Evaluation of the association between periodontal parameters, osteoporosis and osteopenia in post menopausal women. PMID:24910652 | 2013 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio); Bone mineral density (BMD) | not extracted yet |
| Passos 2013 Osteoporosis/osteopenia as an independent factor associated with periodontitis in postmenopausal women: a case–control study DOI:10.1007/s00198-012-2130-7 | 2012 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) | not extracted yet |
| Passos 2013 Osteoporosis/osteopenia as an independent factor associated with periodontitis in postmenopausal women: a case-control study. PMID:23001114 | 2013 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) | not extracted yet |
| Penoni 2016 Association of osteoporosis and bone medication with the periodontal condition in elderly women DOI:10.1007/s00198-015-3437-y | 2015 | this review only | not stated | not extracted yet |
| Penoni 2016 Association of osteoporosis and bone medication with the periodontal condition in elderly women. PMID:26626187 | 2016 | this review only | not stated | not extracted yet |
| Pepelassi 2012 The relationship between osteoporosis and periodontitis in women aged 45–70 years DOI:10.1111/j.1601-0825.2011.01881.x | 2011 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) | not extracted yet |
| Pepelassi 2012 The relationship between osteoporosis and periodontitis in women aged 45-70 years. PMID:22151499 | 2012 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) | not extracted yet |
| Richa 2017 Association between osteoporosis and periodontal disease among postmenopausal Indian women DOI:10.1111/jicd.12223 | 2016 | this review only | not stated | not extracted yet |
| Richa 2017 Association between osteoporosis and periodontal disease among postmenopausal Indian women. PMID:27339765 | 2017 | this review only | not stated | not extracted yet |
| Savic Pavicin 2017 The relationship between periodontal disease, tooth loss and decreased skeletal bone mineral density in ageing women DOI:10.1111/ger.12290 | 2017 | this review only | not stated | not extracted yet |
| Savic Pavicin 2017 The relationship between periodontal disease, tooth loss and decreased skeletal bone mineral density in ageing women. PMID:28812320 | 2017 | this review only | not stated | not extracted yet |
| Singh 2014 Association of bone mineral density with periodontal status in postmenopausal women DOI:10.1111/jicd.12047 | 2013 | this review only | not stated | not extracted yet |
| Singh 2014 Association of bone mineral density with periodontal status in postmenopausal women. PMID:23766246 | 2014 | this review only | not stated | not extracted yet |
| Vishwanath 2011 Correlation of periodontal status and bone mineral density in postmenopausal women: A digital radiographic and quantitative ultrasound study DOI:10.4103/0970-9290.84303 | 2011 | this review only | not stated | not extracted yet |
| Vishwanath 2011 Correlation of periodontal status and bone mineral density in postmenopausal women: a digital radiographic and quantitative ultrasound… PMID:21891899 | 2011 | this review only | not stated | not extracted yet |
| Zamani 2022 Tricinonoic acid and tricindiol, two new irregular sesquiterpenes from an endophytic strain of Fusarium tricinctum. PMID:20221941 | 2010 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) | not extracted yet |
| Zamani 2022 Evaluation of the association between osteoporosis and periodontitis in postmenopausal women: A clinical and radiographic study. PMID:35915711 | 2022 | this review only | Periodontitis severity: clinical attachment loss (CAL, mm) (GRADE table, meta-analysis odds ratio) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Postmenopausal women aged 45 years and above | Peri- and postmenopausal women aged 45 to 80 years (n=3689) |
| Intervention | Low bone mineral density / osteoporosis (DEXA, WHO T-score < -2.5) | Osteoporosis / low BMD by DEXA (hip, lumbar or femoral) |
| Comparison | Individuals with normal BMD | Women with normal BMD |
| Outcomes | Periodontitis assessed by clinical attachment loss (CAL) or CAL and probing depth | Clinical attachment loss; BMD levels; probing depth and other periodontal parameters |
| Study designs | Case-control, cross-sectional and cohort studies conducted 2010 to 2023 | 15 cross-sectional and 2 case-control studies (n=17); 9 in meta-analysis |
| Timing | Not specified | Not specified |