Non-Cochrane · aetiology · PM41618248
Association between periodontitis and acute myocardial infarction: a systematic review and meta-analysis.
Li Li, Wu Huan, Peng Li, et al. · BMC oral health · 2026 · PubMed · doi:10.1186/s12903-026-07699-8
Findings
Population Adults (18 years or older) without prior AMI
16 findings
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Univariable meta-regression: Definition: number of missing teeth/CAL vs CDC/AAP/EWP criteria | Meta-regression coefficient (lnOR difference) -0.13 GRADE not reported Studies not reported |
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Univariable meta-regression: Region: Europe vs America | Meta-regression coefficient (lnOR difference) 0.18 GRADE not reported Studies not reported |
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Univariable meta-regression: Study design: cross-sectional vs case-control | Meta-regression coefficient (lnOR difference) -0.29 GRADE not reported Studies not reported |
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Univariable meta-regression: Region: Asia vs America | Meta-regression coefficient (lnOR difference) -0.26 GRADE not reported Studies not reported |
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Univariable meta-regression: Study design: cohort vs case-control | Meta-regression coefficient (lnOR difference) -0.90 GRADE not reported Studies not reported |
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Univariable meta-regression: Definition: PBH vs CDC/AAP/EWP criteria | Meta-regression coefficient (lnOR difference) -0.03 GRADE not reported Studies not reported |
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Univariable meta-regression: Definition: ICD-10 vs CDC/AAP/EWP criteria | Meta-regression coefficient (lnOR difference) -0.97 GRADE not reported Studies not reported |
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) | OR 1.84 [1.51, 2.23] GRADE not reported 17 studies · 146001 participants |
| Periodontitis (moderate to severe; criteria vary by study) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Trim-and-fill adjusted for publication bias | OR 1.262 [1.027, 1.549] GRADE not reported 17 studies · 146001 participants |
| Periodontal parameter: bleeding on probing (BOP) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Parameter-specific subgroup: BOP | OR 2.901 [1.247, 6.749] GRADE not reported 3 studies |
| Periodontal parameter: clinical attachment loss (CAL) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Parameter-specific subgroup: CAL | OR 1.756 [1.308, 2.357] GRADE not reported 12 studies |
| Periodontal parameter: number of missing teeth | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Parameter-specific subgroup: Number of missing teeth | OR 1.064 [0.945, 1.196] GRADE not reported 5 studies |
| Periodontal parameter: probing depth (PD) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Parameter-specific subgroup: PD | OR 1.148 [1.076, 1.224] GRADE not reported 4 studies |
| Periodontal parameter: remaining bone height (RBH) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Parameter-specific subgroup: RBH | OR 1.590 [1.036, 2.439] GRADE not reported 3 studies |
| Periodontal parameter: radiographic bone loss (RBL) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Parameter-specific subgroup: RBL | OR 8.845 [4.324, 18.096] GRADE not reported 5 studies |
| Periodontal parameter: Community Periodontal Index (CPI) | No periodontitis (periodontally healthy) | Acute myocardial infarction (AMI) Parameter-specific subgroup: CPI | OR 0.905 [0.237, 3.459] GRADE not reported 3 studies |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Holmlund 2006 Severity of periodontal disease and number of remaining teeth are related to the prevalence of myocardial infarction and hypertension in a… PMID:16805679 | 2006 | 1 other review | Acute myocardial infarction (AMI) | not extracted yet |
| Noguchi 2015 Five-year follow-up study of the association between periodontal disease and myocardial infarction among Japanese male workers: MY Health… PMID:25293424 | 2015 | 1 other review | Acute myocardial infarction (AMI) | not extracted yet |
| Bashir 2021 PERIODONTITIS AND MYOCARDIAL INFARCTION RISK: A CASE-CONTROL STUDY DOI:10.47144/phj.v54i4.2141 | 2022 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Bazile 2002 Periodontal assessment of patients undergoing angioplasty for treatment of coronary artery disease. PMID:12083536 | 2002 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Beck 2020 Periodontal disease classifications and incident coronary heart disease in the Atherosclerosis Risk in Communities study. PMID:32449797 | 2020 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Cho 2021 Severe Periodontal Disease Increases Acute Myocardial Infarction and Stroke: A 10-Year Retrospective Follow-up Study. PMID:33478309 | 2021 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Cueto 2005 Periodontitis as risk factor for acute myocardial infarction. A case control study of Spanish adults. PMID:15613077 | 2005 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Gomes-Filho 2020 Severe and moderate periodontitis are associated with acute myocardial infarction. PMID:32219849 | 2020 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Górski 2016 The Association Between Dental Status and Risk of Acute Myocardial Infarction Among Poles: Case-control Study. PMID:28028948 | 2016 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Khosravi Samani 2013 The relationship between acute myocardial infarction and periodontitis. PMID:24009957 | 2013 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Kodovazenitis 2014 Association between periodontitis and acute myocardial infarction: a case-control study of a nondiabetic population. PMID:23713486 | 2014 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Łysek 2018 Relationship between past myocardial infarction, periodontal disease and Porphyromonas gingivalis serum antibodies: A case-control study. PMID:28151544 | 2018 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Nordendahl 2018 Severe Periodontitis Is Associated with Myocardial Infarction in Females. PMID:29596754 | 2018 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Persson 2003 Chronic periodontitis, a significant relationship with acute myocardial infarction. PMID:14643271 | 2003 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Rydén 2016 Periodontitis Increases the Risk of a First Myocardial Infarction: A Report From the PAROKRANK Study. PMID:26762521 | 2016 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Seoane 2022 Periodontitis and Other Risk Factors Related to Myocardial Infarction and Its Follow-Up. PMID:35566746 | 2022 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
| Song 2021 Cardiovascular risks of periodontitis and oral hygiene indicators in patients with diabetes mellitus. PMID:33862198 | 2021 | this review only | Acute myocardial infarction (AMI) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults aged 18 years or older without a prior history of AMI at baseline | Adults; 146,001 participants, 3,199 AMI cases (n=17) |
| Intervention | Periodontitis per established criteria (2017 AAP/EFP, CDC/AAP, EWP, PPC, ICD-10); CAL and PD primary indicators; BOP, RBL, RBH extracted as parameters | Periodontitis (moderate to severe) defined by CDC/AAP, AAP/EFP, EWP, PPC, ICD-10, CAL, PD, radiographic bone loss/height (n=17) |
| Comparison | Adults without periodontitis or periodontally healthy | No periodontitis / periodontally healthy (n=17) |
| Outcomes | Acute myocardial infarction (ESC or universal definition, or ICD-10 codes) | Acute myocardial infarction (n=17) |
| Study designs | Observational studies (case-control, cohort, cross-sectional) | Case-control (n=10), cohort (n=4), cross-sectional (n=2), case-control with prospective follow-up (n=1) |
| Timing | Not specified | Not specified |