Non-Cochrane · intervention · PM41572858
Incisor extrusion with or without molar intrusion for the correction of anterior open bite with clear aligners and comparison of outcomes with fixed appliances incorporating temporary anchorage devices: A systematic review and meta-analysis.
Charoenrat Thanit, Uengkajornkul Phuntin, Changsiripun Chidsanu · Korean journal of orthodontics · 2026 · PubMed · doi:10.4041/kjod25.064
Findings
25 findings
| Population | ||||
|---|---|---|---|---|
| Adult patients with anterior open bite | Clear aligner treatment (CAT) | Fixed appliances incorporating temporary anchorage devices (FATADs) | Vertical position of mandibular first molar (L6) End of treatment (change from pre-treatment) · Retrospective cephalometric studies | MD 0.45 [0.04, 0.86] Very low Downgraded: risk of bias, imprecision 2 studies · 81 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT) | Fixed appliances incorporating temporary anchorage devices (FATADs) | Vertical position of maxillary central incisor (U1) End of treatment (change from pre-treatment) · Retrospective cephalometric studies | MD 0.6 [-0.08, 1.29] Very low Downgraded: risk of bias, imprecision, inconsistency 2 studies · 81 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT) | Fixed appliances incorporating temporary anchorage devices (FATADs) | Vertical position of maxillary first molar (U6) End of treatment (change from pre-treatment) · Retrospective cephalometric studies | MD 1.88 [1.41, 2.35] Very low Downgraded: risk of bias, inconsistency 2 studies · 81 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT) | Fixed appliances incorporating temporary anchorage devices (FATADs) | Vertical position of mandibular central incisor (L1) End of treatment (change from pre-treatment) · Retrospective cephalometric studies | MD 2.35 [0.06, 4.64] Very low Downgraded: risk of bias, imprecision, inconsistency 2 studies · 81 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT) | Fixed appliances incorporating temporary anchorage devices (FATADs) | Overbite End of treatment (change from pre-treatment) · Retrospective cephalometric studies | MD -1.64 [-2.43, -0.86] Very low Downgraded: risk of bias, imprecision, inconsistency 2 studies · 81 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of mandibular first molar (L6) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Suh et al. 2023 (possible overlapping participants) | MD -0.25 [-0.7, 0.19] GRADE not reported 9 studies · 594 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of mandibular central incisor (L1) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies | MD 1.06 [0.63, 1.5] Low 10 studies · 704 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of maxillary central incisor (U1) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies | MD 0.87 [0.47, 1.27] Low 10 studies · 704 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of maxillary first molar (U6) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Harris et al. 2020 (manual tracing, no magnification calibration) | MD -0.01 [-0.34, 0.32] GRADE not reported 9 studies · 614 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of maxillary central incisor (U1) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Suh et al. 2023 (possible overlapping participants) | MD 0.83 [0.4, 1.26] GRADE not reported 9 studies · 600 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of maxillary first molar (U6) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Suh et al. 2023 (possible overlapping participants) | MD 0.03 [-0.31, 0.38] GRADE not reported 9 studies · 600 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of mandibular first molar (L6) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Harris et al. 2020 (manual tracing, no magnification calibration) | MD -0.2 [-0.64, 0.23] GRADE not reported 9 studies · 608 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of mandibular central incisor (L1) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Suh et al. 2023 (possible overlapping participants) | MD 1.03 [0.57, 1.49] GRADE not reported 9 studies · 600 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of mandibular first molar (L6) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies | MD -0.22 [-0.63, 0.19] Low 10 studies · 698 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of maxillary central incisor (U1) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Harris et al. 2020 (manual tracing, no magnification calibration) | MD 0.85 [0.44, 1.26] GRADE not reported 9 studies · 614 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Overbite Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Suh et al. 2023 (possible overlapping participants) | MD 2.71 [2.34, 3.09] GRADE not reported 9 studies · 600 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Overbite Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Harris et al. 2020 (manual tracing, no magnification calibration) | MD 2.71 [2.34, 3.08] GRADE not reported 9 studies · 614 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of mandibular central incisor (L1) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies · Sensitivity analysis excluding Harris et al. 2020 (manual tracing, no magnification calibration) | MD 1.11 [0.66, 1.57] GRADE not reported 9 studies · 614 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Overbite Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies | MD 2.77 [2.42, 3.12] Low 10 studies · 704 participants |
| Adult patients with anterior open bite | Clear aligner treatment (CAT), post-treatment | Pre-treatment (before-and-after within CAT group) | Vertical position of maxillary first molar (U6) Pre-treatment vs end of treatment · Retrospective cephalometric or CBCT studies | MD -0.03 [-0.35, 0.29] Low 10 studies · 704 participants |
| Adult patients with anterior open bite after CAT | Clear aligner treatment (CAT), follow-up (retention, at least 6 months after treatment) | End of CAT treatment (post-treatment) | Vertical position of maxillary central incisor (U1) Post-treatment to retention follow-up (6 months to at least 1 year) · Retrospective cephalometric studies | MD 0.34 [-0.38, 1.05] Very low Downgraded: imprecision 2 studies · 120 participants |
| Adult patients with anterior open bite after CAT | Clear aligner treatment (CAT), follow-up (retention, at least 6 months after treatment) | End of CAT treatment (post-treatment) | Overbite Post-treatment to retention follow-up (6 months to at least 1 year) · Retrospective cephalometric studies | MD 0.02 [-0.34, 0.38] Very low Downgraded: imprecision, inconsistency 2 studies · 120 participants |
| Adult patients with anterior open bite after CAT | Clear aligner treatment (CAT), follow-up (retention, at least 6 months after treatment) | End of CAT treatment (post-treatment) | Vertical position of mandibular central incisor (L1) Post-treatment to retention follow-up (6 months to at least 1 year) · Retrospective cephalometric studies | MD 0.25 [-0.56, 1.05] Very low Downgraded: imprecision 2 studies · 120 participants |
| Adult patients with anterior open bite after CAT | Clear aligner treatment (CAT), follow-up (retention, at least 6 months after treatment) | End of CAT treatment (post-treatment) | Vertical position of maxillary first molar (U6) Post-treatment to retention follow-up (6 months to at least 1 year) · Retrospective cephalometric studies | MD 0.29 [-0.27, 0.84] Very low Downgraded: imprecision 2 studies · 120 participants |
| Adult patients with anterior open bite after CAT | Clear aligner treatment (CAT), follow-up (retention, at least 6 months after treatment) | End of CAT treatment (post-treatment) | Vertical position of mandibular first molar (L6) Post-treatment to retention follow-up (6 months to at least 1 year) · Retrospective cephalometric studies | MD 0.17 [-0.55, 0.89] Very low Downgraded: imprecision 2 studies · 120 participants |
Included primary studies 10
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Chamberland 2024 Noninvasive conservative management of anterior open bite treated with TADs versus clear aligner therapy. PMID:38556610 | 2024 | 1 other review | not stated | not extracted yet |
| Garnett 2019 Cephalometric comparison of adult anterior open bite treatment using clear aligners and fixed appliances. PMID:30280928 | 2019 | 1 other review | not stated | not extracted yet |
| Harris 2020 Evaluation of open bite closure using clear aligners: a retrospective study. PMID:32830306 | 2020 | 1 other review | not stated | not extracted yet |
| Moshiri 2017 Cephalometric evaluation of adult anterior open bite non-extraction treatment with Invisalign. PMID:29160342 | 2017 | 1 other review | not stated | not extracted yet |
| Steele 2022 A comparative assessment of the dentoskeletal effects of clear aligners vs miniplate-supported posterior intrusion with fixed appliances… PMID:35339320 | 2022 | 1 other review | not stated | not extracted yet |
| Suh 2022 Treatment of anterior open bites using non-extraction clear aligner therapy in adult patients. PMID:35527369 | 2022 | 1 other review | not stated | not extracted yet |
| Finkleman 2024 Does planned molar intrusion with aligners assist with closure of anterior open bite? PMID:38970571 | 2024 | this review only | not stated | not extracted yet |
| Khosravi 2017 Management of overbite with the Invisalign appliance. PMID:28364892 | 2017 | this review only | not stated | not extracted yet |
| Pokorna 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Suh 2023 Short-term stability of anterior open bite treatment with clear aligners in adults. PMID:37552148 | 2023 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Clear aligner therapy for adult anterior open bite: a systematic review, descriptive evidence map, and certainty appraisal of reported… (2026) | 6 | 0.43 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Healthy adult patients of any sex and ethnicity with anterior open bite (growing patients and craniofacial anomalies excluded) | Adults with anterior open bite (n=704 in the before-after meta-analysis, 10 studies) |
| Intervention | Clear aligner treatment (CAT); CAT combined with TADs excluded | Invisalign clear aligner treatment (10 studies) |
| Comparison | Fixed appliances incorporating temporary anchorage devices (FATADs); pre-treatment vs post-treatment within CAT; post-treatment vs stability (retention) within CAT; fixed appliances without TADs excluded | FATADs with miniscrews or miniplates (2 studies in meta-analysis, n=81); pre-treatment (10 studies, n=704); post-treatment for stability (2 studies, n=120) |
| Outcomes | Primary: overbite change; secondary: vertical position of U1, L1, U6 and L6 (lateral cephalograms or CBCT) | Overbite, U1, L1, U6 and L6 vertical position, all as mean differences in mm |
| Study designs | Randomized and non-randomized clinical trials, cohort, case-control and before-and-after studies | Four non-randomized controlled trials and six before-and-after studies, all retrospective |
| Timing | Pre-treatment, post-treatment, and at least 6 months after treatment completion (stability) | Pre-treatment, post-treatment, retention follow-up of 6 months to at least 1 year (2 studies) |