Non-Cochrane · aetiology · PM41517515
Temporomandibular Disorders and Orofacial Outcomes in Subjects with Neck Pain and/or Cervicogenic Headache: A Systematic Review with Meta-Analysis.
Bizzarri Paolo, Giusti Andrea, Pernici Marco, et al. · Journal of clinical medicine · 2025 · PubMed · doi:10.3390/jcm15010266
Findings
Population Adults with chronic neck pain and/or cervicogenic headache
11 findings
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Masseter pressure pain threshold | SMD -1.11 [-1.89, -0.32] Very low Downgraded: risk of bias, imprecision, inconsistency 3 studies |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | TMD prevalence (RDC/TMD) | OR 3.64 [1.35, 9.84] Very low Downgraded: risk of bias, imprecision, inconsistency 3 studies · 163 participants |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Temporalis pressure pain threshold Left anterior temporalis | SMD -0.78 [-1.19, -0.38] GRADE not reported 2 studies · 101 participants |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Masseter pressure pain threshold Right masseter origin | SMD -0.50 [-0.97, -0.03] GRADE not reported 2 studies · 109 participants |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Temporalis pressure pain threshold Right anterior temporalis | SMD -0.59 [-0.92, -0.27] GRADE not reported 3 studies · 153 participants |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Maximum assisted mouth opening (mm) Assisted opening subgroup | MD -6.16 [-10.05, -2.28] Very low Downgraded: risk of bias, imprecision, inconsistency 3 studies · 170 participants |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Masseter pressure pain threshold Sensitivity analysis excluding La Touche 2010 | SMD -0.38 [-0.65, -0.11] GRADE not reported 2 studies |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Temporalis pressure pain threshold Right posterior temporalis | SMD -0.41 [-0.81, -0.00] GRADE not reported 2 studies · 96 participants |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Temporalis pressure pain threshold Sensitivity analysis excluding La Touche 2010 | SMD -0.57 [-0.72, -0.42] GRADE not reported 4 studies |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Temporalis pressure pain threshold Right middle temporalis | SMD -0.53 [-0.93, -0.12] GRADE not reported 2 studies · 96 participants |
| Neck pain or cervicogenic headache (exposure) | Asymptomatic controls without neck pain or headache | Temporalis pressure pain threshold | SMD -0.77 [-1.04, -0.50] Very low Downgraded: risk of bias, imprecision, inconsistency 5 studies |
Included primary studies 16
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Bragatto 2016 Associations among temporomandibular disorders, chronic neck pain and neck pain disability in computer office workers: a pilot study DOI:10.1111/joor.12377 | 2016 | this review only | not stated | not extracted yet |
| Bragatto 2016 Associations among temporomandibular disorders, chronic neck pain and neck pain disability in computer office workers: a pilot study. PMID:26732204 | 2016 | this review only | TMD prevalence (RDC/TMD); Masseter pressure pain threshold; Temporalis pressure pain threshold | not extracted yet |
| De-la-Llave-Rincon 2012 Myofascial Trigger Points in the Masticatory Muscles in Patients With and Without Chronic Mechanical Neck Pain DOI:10.1016/j.jmpt.2012.10.008 | 2012 | this review only | not stated | not extracted yet |
| De-la-Llave-Rincon 2012 Myofascial trigger points in the masticatory muscles in patients with and without chronic mechanical neck pain. PMID:23206962 | 2012 | this review only | not stated | not extracted yet |
| Guzel 2022 Evaluation of Temporomandibular Joint Dysfunction in Patients with Chronic Neck Pain DOI:10.53811/ijtcmr.1184011 | 2022 | this review only | TMD prevalence (RDC/TMD); Maximum assisted mouth opening (mm) | not extracted yet |
| La Touche 2010 Bilateral Mechanical-Pain Sensitivity Over the Trigeminal Region in Patients With Chronic Mechanical Neck Pain DOI:10.1016/j.jpain.2009.07.003 | 2010 | this review only | not stated | not extracted yet |
| La Touche 2010 Bilateral mechanical-pain sensitivity over the trigeminal region in patients with chronic mechanical neck pain. PMID:19945351 | 2010 | this review only | Masseter pressure pain threshold; Temporalis pressure pain threshold | not extracted yet |
| Mingels 2019 Preclinical Signs of a Temporomandibular Disorder in Female Patients With Episodic Cervicogenic Headache Versus Asymptomatic Controls: A… DOI:10.1002/pmrj.12156 | 2019 | this review only | not stated | not extracted yet |
| Mingels 2019 Preclinical Signs of a Temporomandibular Disorder in Female Patients With Episodic Cervicogenic Headache Versus Asymptomatic Controls: A… PMID:30859716 | 2019 | this review only | Maximum assisted mouth opening (mm); Temporalis pressure pain threshold | not extracted yet |
| Munoz-Garcia 2016 Chronic Neck Pain and Cervico-Craniofacial Pain Patients Express Similar Levels of Neck Pain-Related Disability, Pain Catastrophizing, and… DOI:10.1155/2016/7296032 | 2016 | this review only | not stated | not extracted yet |
| Munoz-Garcia 2016 Chronic Neck Pain and Cervico-Craniofacial Pain Patients Express Similar Levels of Neck Pain-Related Disability, Pain Catastrophizing, and… PMID:27119020 | 2016 | this review only | Temporalis pressure pain threshold | not extracted yet |
| Munoz-Garcia 2017 Patients with Concomitant Chronic Neck Pain and Myofascial Pain in Masticatory Muscles Have More Widespread Pain and Distal Hyperalgesia… DOI:10.1093/pm/pnw274 | 2016 | this review only | not stated | not extracted yet |
| Munoz-Garcia 2017 Patients with Concomitant Chronic Neck Pain and Myofascial Pain in Masticatory Muscles Have More Widespread Pain and Distal Hyperalgesia… PMID:28034980 | 2017 | this review only | Maximum assisted mouth opening (mm); Masseter pressure pain threshold | not extracted yet |
| Pasinato 2016 Cervical-scapular muscles strength and severity of temporomandibular disorder in women with mechanical neck pain DOI:10.1590/0103-5150.029.002.ao05 | 2016 | this review only | TMD prevalence (RDC/TMD) | not extracted yet |
| Rodrigues 2024 Cervical muscle parameters and allodynia in migraine and cervical pain—A controlled study DOI:10.1002/ejp.2200 | 2023 | this review only | not stated | not extracted yet |
| Rodrigues 2024 Cervical muscle parameters and allodynia in migraine and cervical pain-A controlled study. PMID:37942706 | 2024 | this review only | Temporalis pressure pain threshold | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (18 years or older) with neck pain and/or cervicogenic headache | Adults with chronic neck pain (8 studies, n=400) or cervicogenic headache (1 study, n=44) |
| Intervention | Exposure: neck pain or cervicogenic headache (ICHD-3 or authors' criteria) | Chronic neck pain (8 studies); cervicogenic headache (1 study) |
| Comparison | Adults without neck pain or cervicogenic headache | Asymptomatic controls |
| Outcomes | TMD prevalence; TMD signs and symptoms (bruxism, orofacial pressure pain thresholds, myofascial trigger points, mandibular mobility) | TMD prevalence (n=3 studies); jaw mobility (n=4); masseter PPT (n=3); temporalis PPT (n=5); pain at palpation and myofascial trigger points |
| Study designs | Analytical cross-sectional studies, English language | Analytical cross-sectional studies (n=9) |
| Timing | Not specified | Not specified |