Non-Cochrane · aetiology · PM41439318
Exploring the Bidirectional Association Between Migraine and Temporomandibular Disorders: A Systematic Review and Meta-Analysis.
Dias Marlon Ferreira, Ferro Amanda Costa, Spavieri Juliana Homem Padilha, et al. · Journal of oral rehabilitation · 2026 · PubMed · doi:10.1111/joor.70110
Findings
Population Adults of both sexes
8 findings
| Migraine (exposure) | No migraine (general population controls) | Temporomandibular disorders (TMD) Clinical and community samples (cross-sectional) · All six studies; fixed effect | OR 2.25 [1.91, 2.66] GRADE not reported 6 studies · 4038 participants |
| Migraine (exposure) | No migraine (general population controls) | Temporomandibular disorders (TMD) Clinical and community samples (cross-sectional) · After Baujat exclusion of Memmedova 2021; fixed effect | OR 6.08 [4.8, 7.68] High 5 studies · 3342 participants |
| Migraine (exposure) | No migraine (general population controls) | Temporomandibular disorders (TMD) Clinical and community samples (cross-sectional) · All six studies; random effects | OR 4.25 [0.94, 19.3] GRADE not reported 6 studies · 4038 participants |
| Migraine (exposure) | No migraine (general population controls) | Temporomandibular disorders (TMD) Clinical and community samples (cross-sectional) · After Baujat exclusion of Memmedova 2021; random effects | OR 7.3 [2.5, 21.32] GRADE not reported 5 studies · 3342 participants |
| TMD (exposure) | No TMD (controls) | Migraine Clinical and community samples (cross-sectional) · All six studies; random effects | OR 1.39 [0.12, 16.41] GRADE not reported 6 studies · 4038 participants |
| TMD (exposure) | No TMD (controls) | Migraine Clinical and community samples (cross-sectional) · All six studies; fixed effect | OR 0.5 [0.44, 0.56] GRADE not reported 6 studies · 4038 participants |
| TMD (exposure) | No TMD (controls) | Migraine Clinical and community samples (cross-sectional) · After Baujat exclusion of Cioffi 2014; random effects | OR 3.45 [0.73, 16.31] GRADE not reported 5 studies · 2476 participants |
| TMD (exposure) | No TMD (controls) | Migraine Clinical and community samples (cross-sectional) · After Baujat exclusion of Cioffi 2014; fixed effect | OR 2.64 [2.19, 3.18] High 5 studies · 2476 participants |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Calixtre 2024 The Association Between the Central Sensitisation Inventory and Temporomandibular Disorders Is Confounded by Migraine, Depression,… PMID:39287359 | 2024 | this review only | not stated | not extracted yet |
| Cioffi 2014 Social impairment of individuals suffering from different types of chronic orofacial pain. PMID:24935241 | 2014 | this review only | Temporomandibular disorders (TMD); Migraine | not extracted yet |
| Contreras 2018 Systemic diseases and other painful conditions in patients with temporomandibular disorders and migraine. PMID:30043839 | 2018 | this review only | not stated | not extracted yet |
| da Silva Junior 2010 Chronic headache and comorbidities: a two-phase, population-based, cross-sectional study. PMID:20163479 | 2010 | this review only | not stated | not extracted yet |
| Dahan 2016 Self-Reported Migraine and Chronic Fatigue Syndrome Are More Prevalent in People with Myofascial vs Nonmyofascial Temporomandibular… PMID:26817027 | 2016 | this review only | not stated | not extracted yet |
| Di Paolo 2009 ID migraine questionnaire in temporomandibular disorders with craniofacial pain: a study by using a multidisciplinary approach. PMID:19495559 | 2009 | this review only | not stated | not extracted yet |
| Fernandes 2013 Temporomandibular disorders, sleep bruxism, and primary headaches are mutually associated. PMID:23424716 | 2013 | this review only | Temporomandibular disorders (TMD); Migraine | not extracted yet |
| Fragoso 2010 Prevalence of parafunctional habits and temporomandibular dysfunction symptoms in patients attending a tertiary headache clinic. PMID:20602039 | 2010 | this review only | not stated | not extracted yet |
| Glaros 2007 Headache and temporomandibular disorders: evidence for diagnostic and behavioural overlap. PMID:17441972 | 2007 | this review only | not stated | not extracted yet |
| Goncalves 2011 Temporomandibular disorders are differentially associated with headache diagnoses: a controlled study. PMID:21368664 | 2011 | this review only | Temporomandibular disorders (TMD); Migraine | not extracted yet |
| Goncalves 2013 Do women with migraine have higher prevalence of temporomandibular disorders? PMID:23117652 | 2013 | this review only | Temporomandibular disorders (TMD); Migraine | not extracted yet |
| Memmedova 2021 Evaluation of temporomandibular joint disorder in headache patients. PMID:33604763 | 2021 | this review only | Temporomandibular disorders (TMD); Migraine | not extracted yet |
| Proenca 2024 Clinical features of chronic primary pain in individuals presenting painful temporomandibular disorder and comorbidities. PMID:37727030 | 2024 | this review only | not stated | not extracted yet |
| Sharma 2020 Attributes Germane to Temporomandibular Disorders and Their Associations with Five Chronic Overlapping Pain Conditions. PMID:32975541 | 2020 | this review only | not stated | not extracted yet |
| Silva Junior 2014 Temporo-mandibular disorders are an important comorbidity of migraine and may be clinically difficult to distinguish them from… PMID:24604361 | 2014 | this review only | not stated | not extracted yet |
| Troeltzsch 2011 Prevalence and association of headaches, temporomandibular joint disorders, and occlusal interferences. PMID:21640243 | 2011 | this review only | not stated | not extracted yet |
| Wieckiewicz 2020 Prevalence and Overlaps of Headaches and Pain-Related Temporomandibular Disorders Among the Polish Urban Population. PMID:31465030 | 2020 | this review only | Temporomandibular disorders (TMD); Migraine | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults of both sexes | Adults (n=17 studies, 10131 individuals; 6 studies in meta-analysis) |
| Intervention | Exposure: presence of TMD of any type or migraine | Migraine as exposure for TMD (n=6 studies); TMD as exposure for migraine (n=6 studies) |
| Comparison | Absence of the respective condition | Participants without migraine or without TMD |
| Outcomes | Prevalence or risk of migraine or TMD | TMD (OR 2.25 overall; 6.08 after excluding Memmedova 2021) and migraine (OR 0.50 overall; 2.64 after excluding Cioffi 2014) |
| Study designs | Observational cross-sectional studies in any language; TMD by RDC/TMD or DC/TMD; migraine by ICHD | Analytical cross-sectional (n=14) and descriptive cross-sectional (n=3) |
| Timing | Not specified | Not specified |