Non-Cochrane · umbrella · PM40576216
The Impacts of Probiotics Supplementation on the Treatment of Periodontitis: An Umbrella Meta-Analysis.
Tan Junfeng, Zhang Dan, Cheng Li, et al. · Nutrition reviews · 2026 · PubMed · doi:10.1093/nutrit/nuae190
Findings
Population People with periodontitis (healthy adults with periodontitis or periodontal disease)
34 findings
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Sample size >500 | ES 0.14 [-0.09, 0.37] GRADE not reported 10 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Number of included studies >10 | ES 0.17 [-0.06, 0.41] GRADE not reported 10 studies |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Duration 8-16 weeks | ES 0.11 [-0.14, 0.36] GRADE not reported 7 studies |
| Probiotic supplementation | Control group | Bleeding on probing (BOP) Analyzed as WMD | WMD -8.20 [-15.10, -1.31] GRADE not reported 3 studies |
| Probiotic supplementation | Control group | PPD reduction in deep pockets Overall | ES -0.28 [-0.84, 0.29] GRADE not reported 4 studies |
| Probiotic supplementation | Control group | Plaque index (PI) Overall | ES 0.00 [-0.14, 0.15] GRADE not reported 8 studies |
| Probiotic supplementation | Control group | Plaque index (PI) Sample size <1000 | ES -0.13 [-0.30, 0.04] GRADE not reported 4 studies |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Sample size <=500 | ES -0.15 [-0.52, 0.22] GRADE not reported 14 studies |
| Probiotic supplementation | Control group | Plaque index (PI) Duration <=8 weeks | ES 0.11 [-0.08, 0.30] GRADE not reported 5 studies |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Duration <=8 weeks | ES 0.21 [-0.03, 0.46] GRADE not reported 6 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Sample size <=1000 | ES 0.15 [-0.09, 0.39] GRADE not reported 11 studies |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Duration >16 weeks | ES -0.14 [-0.53, 0.25] GRADE not reported 9 studies |
| Probiotic supplementation | Control group | Bleeding on probing (BOP) Analyzed as SMD | SMD 0.04 [-0.44, 0.53] GRADE not reported 4 studies |
| Probiotic supplementation | Control group | Gingival index (GI) Sensitivity: excluding Z. Gheisary (e) (2022) | ES 0.37 [0.08, 0.67] GRADE not reported Studies not reported |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Duration >16 weeks | ES 0.23 [-0.19, 0.64] GRADE not reported 7 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Duration <=16 weeks | ES 0.15 [-0.03, 0.33] GRADE not reported 7 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Trim-and-fill analysis (2 imputed studies) Unresolved: the two extractors disagree on this row. | ES 0.05 [-0.18, 0.30] GRADE not reported 16 studies |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Trim-and-fill analysis | ES -0.03 [-0.24, 0.17] GRADE not reported Studies not reported |
| Probiotic supplementation | Control group | Plaque index (PI) Number of included studies <10 | ES -0.37 [-0.83, 0.09] GRADE not reported 2 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Sensitivity: excluding J. Li (c) (2023) | ES -0.52 [-0.75, -0.28] GRADE not reported Studies not reported |
| Probiotic supplementation | Control group | Plaque index (PI) Number of included studies >=10 | ES 0.02 [-0.25, 0.28] GRADE not reported 6 studies |
| Probiotic supplementation | Control group | Plaque index (PI) Sample size >=1000 | ES -0.14 [-0.55, 0.27] GRADE not reported 4 studies |
| Probiotic supplementation | Control group | PPD reduction in medium (moderate) pockets Overall | ES -0.10 [-0.36, 0.16] GRADE not reported 4 studies |
| Probiotic supplementation | Control group | Gingival index (GI) Overall | ES -0.30 [-0.81, 0.21] GRADE not reported 4 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Overall | ES 0.16 [-0.04, 0.36] GRADE not reported 14 studies |
| Probiotic supplementation | Control group | Plaque index (PI) Overall (Table 3 subgroup analysis reference) | ES -0.11 [-0.27, 0.05] GRADE not reported 8 studies |
| Probiotic supplementation | Control group | Plaque index (PI) Duration >8 weeks | ES -0.34 [-0.69, 0.01] GRADE not reported 3 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Sample size >1000 | ES 0.23 [-0.07, 0.54] GRADE not reported 3 studies |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Number of included studies <=10 | ES -0.01 [-0.34, 0.32] GRADE not reported 10 studies |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Duration not reported | ES -0.43 [-0.71, -0.15] GRADE not reported 2 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Sensitivity: excluding R. Martin-Cabezas (c) (2016) | ES -0.42 [-0.68, -0.16] GRADE not reported Studies not reported |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Overall | ES -0.03 [-0.22, 0.16] GRADE not reported 24 studies |
| Probiotic supplementation | Control group | Probing pocket depth (PPD) Number of included studies >10 | ES -0.04 [-0.30, 0.22] GRADE not reported 14 studies |
| Probiotic supplementation | Control group | Clinical attachment level (CAL) Number of included studies <=10 | ES 0.10 [-0.29, 0.49] GRADE not reported 4 studies |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ethan 2021 [Lipoproteins as serum inhibitors in rubella hemagglutination inhibition test and their elimination (author's transl)]. PMID:202112 | 1977 | 2 other reviews | not stated | not extracted yet |
| Donos 2020 The adjunctive use of host modulators in non‐surgical periodontal therapy. A systematic review of randomized, placebo‐controlled clinical… DOI:10.1111/jcpe.13232 | 2020 | this review only | not stated | not extracted yet |
| Gheisary 2022 The Clinical, Microbiological, and Immunological Effects of Probiotic Supplementation on Prevention and Treatment of Periodontal Diseases:… DOI:10.3390/nu14051036 | 2022 | this review only | not stated | not extracted yet |
| Gruner 2016 Probiotics for managing caries and periodontitis: Systematic review and meta-analysis DOI:10.1016/j.jdent.2016.03.002 | 2016 | this review only | not stated | not extracted yet |
| Hardan 2022 The Use of Probiotics as Adjuvant Therapy of Periodontal Treatment: A Systematic Review and Meta-Analysis of Clinical Trials DOI:10.3390/pharmaceutics14051017 | 2022 | this review only | not stated | not extracted yet |
| Ho 2020 A Systematic Review and Meta-analysis of Clinical, Immunological, and Microbiological Shift in Periodontitis After Nonsurgical Periodontal… DOI:10.1016/j.jebdp.2020.101397 | 2020 | this review only | not stated | not extracted yet |
| Hu 2021 CLINICAL EFFICACY OF PROBIOTICS AS AN ADJUNCTIVE THERAPY TO SCALING AND ROOT PLANNING IN THE MANAGEMENT OF PERIODONTITIS: A SYSTEMATIC… DOI:10.1016/j.jebdp.2021.101547 | 2021 | this review only | not stated | not extracted yet |
| Huang 2022 Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis DOI:10.1136/bmjopen-2022-060753 | 2022 | this review only | not stated | not extracted yet |
| Ikram 2018 Systematic review and meta‐analysis of double‐blind, placebo‐controlled, randomized clinical trials using probiotics in chronic… DOI:10.1111/jicd.12338 | 2018 | this review only | not stated | not extracted yet |
| Li 2023 Probiotic adjuvant treatment in combination with scaling and root planing in chronic periodontitis: a systematic review and meta-analysis DOI:10.3920/bm2022.0056 | 2023 | this review only | not stated | not extracted yet |
| Liu 2020 Effect of probiotics on gingival inflammation and oral microbiota: A meta‐analysis DOI:10.1111/odi.13861 | 2021 | this review only | not stated | not extracted yet |
| Martin-Cabezas 2016 Clinical efficacy of probiotics as an adjunctive therapy to non‐surgical periodontal treatment of chronic periodontitis: a systematic… DOI:10.1111/jcpe.12545 | 2016 | this review only | not stated | not extracted yet |
| Mishra 2022 Role of probiotics in adjunct to non-surgical periodontal therapy in patients with chronic periodontitis: a systematic review and… DOI:10.23812/21-2supp1-6 | 2021 | this review only | not stated | not extracted yet |
| Nadelman 2018 Are dairy products containing probiotics beneficial for oral health? A systematic review and meta-analysis DOI:10.1007/s00784-018-2682-9 | 2018 | this review only | not stated | not extracted yet |
| Sayardoust 2022 Do Probiotics Cause a Shift in the Microbiota of Dental Implants—A Systematic Review and Meta-Analysis DOI:10.3389/fcimb.2022.823985 | 2022 | this review only | not stated | not extracted yet |
| Song 2020 DOI:10.26355/eurrev_202004_21032 | NR | this review only | not stated | not extracted yet |
| Zhao 2021 Efficacy of Probiotics as Adjunctive Therapy to Nonsurgical Treatment of Peri-Implant Mucositis: A Systematic Review and Meta-Analysis DOI:10.3389/fphar.2020.541752 | 2021 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients or healthy adults with periodontitis | People with periodontitis or periodontal disease (n=17 meta-analyses) |
| Intervention | Probiotics | Probiotics supplementation |
| Comparison | Control group | Control |
| Outcomes | PI, GI, PPD, CAL, BOP, PDD reduction in moderate and deep pockets | PPD (24 datasets), PI (8), CAL (14), BOP (SMD 4, WMD 3), GI (4), PPD reduction in medium pockets (4) and deep pockets (4) |
| Study designs | Umbrella meta-analysis (meta-analyses of RCTs) | Meta-analyses of RCTs published 2016-2023 (17 meta-analyses, 65 datasets) |
| Timing | Not specified | Intervention duration from 3 to 48 weeks in included meta-analyses |