Cochrane · systematic review · CD011537
Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction
Craciunas, L, Tsampras, N, Raine‐Fenning, N, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyIntrauterine administration of hCG for women undergoing assisted reproduction
Population: subfertile women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Cleavage stage: hCG < 500 IU | RR 0.76 [0.58, 1.01] | 1 study · 280 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage | RR 1.04 [0.81, 1.35] | 11 studies · 3927 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy Cleavage stage: hCG < 500 IU | RR 0.88 [0.7, 1.1] | 1 study · 280 participants | Very low Downgraded: risk of bias, imprecision |
Complications | no estimate extracted | 7 studies · 1764 participants | Very low Downgraded: risk of bias, imprecision |
Intrauterine administration of hCG for women undergoing assisted reproduction
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth ‐ cleavage stage: hCG < 500 IU RR | RR 0.76 [0.58, 1.01] | 1 study · 280 participants | Very low Downgraded: risk of bias, imprecision |
Live birth ‐ cleavage stage: hCG ≥ 500 IU RR | RR 1.57 [1.32, 1.87] | 3 studies · 914 participants | Moderate Downgraded: risk of bias |
Live birth ‐ blastocyst stage: hCG ≥ 500 IU RR | RR 0.92 [0.8, 1.04] | 2 studies · 1666 participants | Moderate Downgraded: risk of bias |
Pregnancy ‐ cleavage stage: hCG < 500 IU RR | RR 0.88 [0.7, 1.1] | 1 study · 280 participants | Very low Downgraded: risk of bias, imprecision |
Pregnancy ‐ cleavage stage: hCG ≥ 500 IU RR | RR 1.41 [1.25, 1.58] | 7 studies · 1414 participants | Moderate Downgraded: risk of bias |
Pregnancy ‐ blastocyst stage: hCG ≥ 500 IU RR | RR 0.95 [0.86, 1.06] | 3 studies · 1991 participants | Moderate Downgraded: risk of bias |
Miscarriage | RR 1.09 [0.83, 1.43] | 7 studies · 3395 participants | Very low Downgraded: risk of bias, imprecision |
Other complications | no estimate extracted | 3 studies · 915 participants | Very low Downgraded: risk of bias, imprecision |