Cochrane · systematic review · CD010995
Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake‐up stroke
Roaldsen, MB, Lindekleiv, H, Mathiesen, EB · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 5 · 83.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyIntravenous thrombolytic treatment compared to standard medical care for wake‐up stroke
Population: people with stroke upon awakening
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Independent functional outcome at end of Intravenous thrombolytic treatment vs standard medical care | RR 1.13 [1.01, 1.26] | 5 studies · 763 participants | High |
Symptomatic intracranial haemorrhage at Intravenous thrombolytic treatment vs standard medical care | RR 3.47 [0.98, 12.26] | 4 studies · 754 participants | High |
Death at Intravenous thrombolytic treatment vs standard medical care | RR 0.68 [0.43, 1.07] | 5 studies · 763 participants | High |
Endovascular treatment compared to standard medical care for wake‐up stroke
Population: people with stroke upon awakening
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Independent functional outcome at end of Endovascular treatment vs standard medical care | RR 5.12 [2.57, 10.17] | 2 studies · 205 participants | High |
Intracranial haemorrhage at Endovascular treatment vs standard medical care | no estimate extracted | NR | No studies |
Death at Endovascular treatment vs standard medical care | RR 0.68 [0.43, 1.07] | 2 studies · 205 participants | High |
Recanalisation therapies compared to no recanalisation therapies for wake‐up stroke
Population: wake‐up stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Independent functional outcome (mRS score 0 to 2) at end of Recanalisation therapies vs no recanalisation therapies | no estimate extracted | NR | No studies |
Symptomatic intracranial haemorrhage at 14 days Recanalisation therapies vs no recanalisation therapies | no estimate extracted | NR | No studies |
Dead at end of Recanalisation therapies vs no recanalisation therapies | no estimate extracted | NR | No studies |
Quality of life at end of Recanalisation therapies vs no recanalisation therapies | no estimate extracted | NR | No studies |
Neurological status at 7 to 14 days and at end of Recanalisation therapies vs no recanalisation therapies | no estimate extracted | NR | No studies |