Cochrane · systematic review · CD010692
Oxycodone for neuropathic pain in adults
Gaskell, H, Derry, S, Stannard, C, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyOxycodone MR compared with placebo for neuropathic pain
Population: adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
'Substantial benefit' (≥ 50% reduction in pain or PGIC very much improved) Oxycodone MR vs placebo | no estimate extracted | NR | Very low |
'Moderate benefit' (≥ 30% reduction in pain or PGIC much or very much improved) Oxycodone MR vs placebo | no estimate extracted | 3 studies · 537 participants | Very low |
Withdrawals due to adverse events Oxycodone MR vs placebo | no estimate extracted | 5 studies · 680 participants | Very low |
Withdrawals due to lack of efficacy Oxycodone MR vs placebo | no estimate extracted | 5 studies · 680 participants | Very low |
Serious adverse events Oxycodone MR vs placebo | no estimate extracted | 4 studies · 352 participants | Very low |
Death Oxycodone MR vs placebo | no estimate extracted | 5 studies · 680 participants | Very low |
Comparison
Population: adults with neuropathic pain (two studies in peripheral diabetic neuropathy and one study in postherpetic neuralgia)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
At least 50% reduction in pain or equivalent | no estimate extracted | NR | No studies |
"Moderate" benefit At least 30% reduction in pain | no estimate extracted | 1 study · 159 participants | Very low |
Proportion below 30/100 mm on VAS | no estimate extracted | NR | No studies |
Patient Global Impression of Change much or very much improved | no estimate extracted | 1 study · 38 participants | Very low |
Adverse event withdrawals | no estimate extracted | 3 studies · 254 participants | Very low |
Serious adverse events | no estimate extracted | 3 studies · 254 participants | Very low |
Death | no estimate extracted | 3 studies · 254 participants | Very low |