Cochrane · systematic review · CD010001
Vasodilators for women undergoing fertility treatment
Gutarra‐Vilchez, RB, Bonfill Cosp, X, Glujovsky, D, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyVasodilator compared to placebo or no treatment for women undergoing fertility treatment
Population: women undergoing fertility treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Vasodilator vs placebo or no treatment | RR 1.18 [0.83, 1.69] | 3 studies · 350 participants | Moderate Downgraded: imprecision |
Vasodilator side effects Vasodilator vs placebo or no treatment | RR 2.35 [1.51, 3.66] | 4 studies · 418 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Clinical pregnancy Vasodilator vs placebo or no treatment | RR 1.45 [1.19, 1.77] | 11 studies · 1054 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Thickened endometrium Vasodilator vs placebo or no treatment | no estimate extracted | 5 studies · 477 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Multiple gestation or birth Vasodilator vs placebo or no treatment | RR 1.15 [0.55, 2.42] | 3 studies · 370 participants | Low Downgraded: imprecision |
Spontaneous miscarriage Vasodilator vs placebo or no treatment | RR 0.83 [0.37, 1.86] | 3 studies · 350 participants | Low Downgraded: imprecision |
Ectopic pregnancy Vasodilator vs placebo or no treatment | RR 1.48 [0.25, 8.69] | 2 studies · 250 participants | Low Downgraded: imprecision |
Vasodilator compared with placebo/no treatment for women undergoing fertility treatment
Population: women undergoing fertility treatment
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Vasodilator vs placebo/no treatment | RR 1.18 [0.82, 1.69] | 3 studies · 350 participants | Moderate |
Vasodilator side effects Vasodilator vs placebo/no treatment | RR 1.63 [0.33, 7.93] | 2 studies · 258 participants | Low |
Clinical pregnancy Vasodilator vs placebo/no treatment | RR 1.38 [1, 1.92] | 8 studies · 717 participants | Low |
Multiple gestation Vasodilator vs placebo/no treatment | RR 0.89 [0.39, 2.03] | 2 studies · 250 participants | Moderate |
Spontaneous miscarriage Vasodilator vs placebo/no treatment | RR 0.84 [0.37, 1.91] | 3 studies · 350 participants | Moderate |
Ectopic pregnancy Vasodilator vs placebo/no treatment | RR 1.47 | 2 studies · 250 participants | Moderate |