Cochrane · intervention · CD007975
Topical treatments for HIV‐related oral ulcers
Kuteyi, T, Okwundu, CI · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Full textEvery question was extracted from the full review (methods and results), not only its Summary of Findings table.
Questions
20
current version
GRADE rated
0
No studies
20
Included studies
0
as reported
No studies 20 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers | Insufficient data |
| Intervention | Topical corticosteroids; Topical thalidomide; Antiseptic mouth washes such as chlorhexidine; Any HAART regimen + any topical treatment | Insufficient data |
| Comparison | Another topical agent; Placebo; HAART regimen alone | Insufficient data |
| Outcomes | Healing of ulceration; Pain relief; Duration to heal oral ulcerations after initiation of treatment; Incidence and recurrence after healing of ulcers; Adverse effects of long‐term use of available topical agents | Insufficient data |
| Study designs | Randomised controlled trials | Insufficient data |
| Timing | Not specified | Insufficient data |
Search date: 2011-05. Databases: PUBMED; EMBASE; The Cochrane Central Register of Controlled Trials (CENTRAL); AEGIS; ClinicalTrials.gov
Questions and results
Current version onlyTopical corticosteroids vs Another topical agent or placebo
Population: HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain relief | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Adverse effects of long‐term use of available topical agents | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Duration to heal oral ulcerations after initiation of treatment | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Healing of ulceration | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Incidence and recurrence after healing of ulcers | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Topical thalidomide vs Another topical agent or placebo
Population: HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence and recurrence after healing of ulcers | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Pain relief | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Adverse effects of long‐term use of available topical agents | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Healing of ulceration | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Duration to heal oral ulcerations after initiation of treatment | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo
Population: HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain relief | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Incidence and recurrence after healing of ulcers | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Duration to heal oral ulcerations after initiation of treatment | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Healing of ulceration | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Adverse effects of long‐term use of available topical agents | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
HAART regimen + topical treatment vs HAART regimen alone
Population: HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Adverse effects of long‐term use of available topical agents | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Duration to heal oral ulcerations after initiation of treatment | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Healing of ulceration | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Pain relief | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Incidence and recurrence after healing of ulcers | No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6… | 0 studies | No studies |
Topical corticosteroids vs Another topical agent or placebo
Population: HIV‐positive individuals of at least 15 years of age with one or more painful intraoral ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration to heal oral ulcerations after initiation of treatment | no estimate extracted | 0 studies | No studies |
Incidence and recurrence after healing of ulcers | no estimate extracted | 0 studies | No studies |
Adverse effects of long‐term use of available topical agents | no estimate extracted | 0 studies | No studies |
Healing of ulceration | no estimate extracted | 0 studies | No studies |
Pain relief | no estimate extracted | 0 studies | No studies |
Topical thalidomide vs Another topical agent or placebo
Population: HIV‐positive individuals of at least 15 years of age with one or more painful intraoral ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration to heal oral ulcerations after initiation of treatment | no estimate extracted | 0 studies | No studies |
Pain relief | no estimate extracted | 0 studies | No studies |
Incidence and recurrence after healing of ulcers | no estimate extracted | 0 studies | No studies |
Adverse effects of long‐term use of available topical agents | no estimate extracted | 0 studies | No studies |
Healing of ulceration | no estimate extracted | 0 studies | No studies |
Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo
Population: HIV‐positive individuals of at least 15 years of age with one or more painful intraoral ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration to heal oral ulcerations after initiation of treatment | no estimate extracted | 0 studies | No studies |
Incidence and recurrence after healing of ulcers | no estimate extracted | 0 studies | No studies |
Pain relief | no estimate extracted | 0 studies | No studies |
Adverse effects of long‐term use of available topical agents | no estimate extracted | 0 studies | No studies |
Healing of ulceration | no estimate extracted | 0 studies | No studies |
HAART regimen + topical treatment vs HAART regimen alone
Population: HIV‐positive individuals of at least 15 years of age with one or more painful intraoral ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence and recurrence after healing of ulcers | no estimate extracted | 0 studies | No studies |
Healing of ulceration | no estimate extracted | 0 studies | No studies |
Pain relief | no estimate extracted | 0 studies | No studies |
Adverse effects of long‐term use of available topical agents | no estimate extracted | 0 studies | No studies |
Duration to heal oral ulcerations after initiation of treatment | no estimate extracted | 0 studies | No studies |