Cochrane · systematic review · CD006536
Stem cell treatment for acute myocardial infarction
Fisher, SA, Zhang, H, Doree, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCells compared to no cells for acute myocardial infarction (AMI)
Population: patients with AMI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality ‐ short‐term Cells vs no cells | RR 0.8 [0.43, 1.49] | 17 studies · 1365 participants | Moderate Downgraded: imprecision |
All‐cause mortality ‐ long‐term Cells vs no cells | RR 0.93 [0.58, 1.5] | 14 studies · 996 participants | Moderate Downgraded: imprecision |
Cardiovascular mortality ‐ short‐term Cells vs no cells | RR 0.72 [0.28, 1.82] | 7 studies · 290 participants | Moderate Downgraded: imprecision |
Cardiovascular mortality ‐ long‐term Cells vs no cells | RR 1.04 [0.54, 1.99] | 9 studies · 527 participants | Moderate Downgraded: imprecision |
Composite death, reinfarction and hospitalisation for heart failure ‐ short‐term Cells vs no cells | RR 0.36 [0.12, 1.14] | 3 studies · 379 participants | Moderate Downgraded: imprecision |
Composite death, reinfarction and hospitalisation for heart failure ‐ long‐term Cells vs no cells | RR 0.63 [0.36, 1.1] | 6 studies · 497 participants | Moderate Downgraded: imprecision |
Comparison
Population: Anyone diagnosed with AMI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality <12 months | RR 0.75 [0.39, 1.45] | 15 studies · 1008 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Mortality >12 months | RR 0.59 [0.22, 1.56] | 6 studies · 494 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Reinfarction <12 months | RR 0.61 [0.29, 1.25] | 13 studies · 960 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Reinfarction >12 months | RR 0.75 [0.35, 1.62] | 8 studies · 669 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Adverse Events (see comments) | no estimate extracted | 13 studies · 1034 participants | Low Downgraded: risk of bias, inconsistency, indirectness |
LVEF (%) (MRI) <12 months | 1.78 [0.27, 3.28] | 17 studies · 879 participants | High |
LVEF (%) (MRI) >12 months | 3.07 [0.21, 5.93] | 7 studies · 328 participants | High |
Comparison
Population: Anyone diagnosed with AMI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality 1‐12 months | RR 0.62 [0.22, 1.76] | 5 studies · 391 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness, publication bias |
Adverse Events (see comments) | no estimate extracted | 5 studies · 296 participants | Low Downgraded: risk of bias, inconsistency, indirectness, publication bias |
LVEF (%) (MRI) | 2.19 | 5 studies · 298 participants | Low Downgraded: risk of bias, inconsistency, indirectness, publication bias |