Cochrane · systematic review · CD005351
Non‐invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema
Berbenetz, N, Wang, Y, Brown, J, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyNPPV compared to SMC for cardiogenic pulmonary oedema
Population: People with cardiogenic pulmonary oedema
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HOSPITAL MORTALITY NPPV vs SMC | RR 0.65 [0.51, 0.82] | 21 studies · 2484 participants | Low Downgraded: risk of bias, imprecision |
ETI RATE NPPV vs SMC | RR 0.49 [0.38, 0.62] | 20 studies · 2449 participants | Moderate Downgraded: risk of bias |
ACUTE MI INCIDENCE NPPV vs SMC | RR 1.03 [0.91, 1.16] | 5 studies · 1313 participants | Moderate Downgraded: imprecision |
HOSPITAL LENGTH OF STAY NPPV vs SMC | no estimate extracted | 11 studies · 1714 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
ICU LENGTH OF STAY NPPV vs SMC | no estimate extracted | 6 studies · 587 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
INTOLERANCE TO ALLOCATED TREATMENT ‐ not reported NPPV vs SMC | no estimate extracted | NR | No studies |
ADVERSE EVENTS NPPV vs SMC | no estimate extracted | 11 studies · 2038 participants | Low Downgraded: risk of bias, imprecision |
Non‐invasive positive pressure ventilation (CPAP and bilevel NPPV) for cardiogenic pulmonary edema
Population: patients with cardiogenic pulmonary oedema
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hospital mortalityY | RR 0.66 [0.48, 0.89] | 20 studies · 1107 participants | High |
Endotracheal intubation rate | RR 0.52 [0.36, 0.75] | 22 studies · 1261 participants | Low |
Incidence of acute myocardial infarction (During intervention) | RR 1.24 [0.79, 1.95] | 8 studies · 461 participants | Moderate |
Incidence of acute myocardial infarction (After intervention) | RR 0.7 [0.11, 4.26] | 4 studies · 154 participants | Very low |
Intolerance to allocated treatment | RR 0.47 [0.29, 0.77] | 13 studies · 1848 participants | Moderate Downgraded: inconsistency |
Hospital length of stay | no estimate extracted | 10 studies · 542 participants | Very low Downgraded: inconsistency |
Intensive care unit length of stay (Copy) | no estimate extracted | 6 studies · 222 participants | Low |