Cochrane · systematic review · CD005072
Levonorgestrel‐releasing intrauterine device (LNG‐IUD) for symptomatic endometriosis following surgery
Gibbons, T, Georgiou, EX, Cheong, YC, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
7
No studies
8
Included studies
NR
No studies 8 · 53.3%Ungraded 0 · 0%Very low 7 · 46.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyPostoperative use of LNG‐IUD compared to expectant management for symptomatic endometriosis following surgery
Population: Patients with symptomatic endometriosis following surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall pain at 12 months  Postoperative use of LNG‐IUD vs expectant management | no estimate extracted | NR | No studies |
Chronic pelvic pain at 12 months  Postoperative use of LNG‐IUD vs expectant management | no estimate extracted | NR | No studies |
Dysmenorrhoea at 12 months  Postoperative use of LNG‐IUD vs expectant management | no estimate extracted | 95 participants | Very low Downgraded: imprecision |
Improvement of the most troublesome symptom at 12 months  Postoperative use of LNG‐IUD vs expectant management | no estimate extracted | NR | No studies |
Quality of life at 12 months  Postoperative use of LNG‐IUD vs expectant management | no estimate extracted | 1 study · 55 participants | Very low Downgraded: imprecision |
Patient satisfaction at 12 months Postoperative use of LNG‐IUD vs expectant management | no estimate extracted | 2 studies · 95 participants | Very low Downgraded: imprecision |
Adverse events  Postoperative use of LNG‐IUD vs expectant management | no estimate extracted | 1 study · 55 participants | Very low Downgraded: imprecision |
Postoperative use of LNG‐IUD compared to postoperative GnRH‐a for symptomatic endometriosis after surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
 Postoperative use of LNG‐IUD vs postoperative GnRH‐a | no estimate extracted | NR | No studies |
Overall pain at 12 months  Postoperative use of LNG‐IUD vs postoperative GnRH‐a | no estimate extracted | NR | No studies |
Chronic pelvic pain at 12 months  Postoperative use of LNG‐IUD vs postoperative GnRH‐a | no estimate extracted | 1 study · 40 participants | Very low Downgraded: imprecision |
Dysmenorrhoea at 12 months  Postoperative use of LNG‐IUD vs postoperative GnRH‐a | no estimate extracted | 1 study · 18 participants | Very low Downgraded: imprecision |
Improvement of the most troublesome symptom at 12 months  Postoperative use of LNG‐IUD vs postoperative GnRH‐a | no estimate extracted | NR | No studies |
Quality of life at 12 months  Postoperative use of LNG‐IUD vs postoperative GnRH‐a | no estimate extracted | NR | No studies |
Patient satisfaction at 12 months Postoperative use of LNG‐IUD vs postoperative GnRH‐a | no estimate extracted | NR | No studies |
Adverse events  Postoperative use of LNG‐IUD vs postoperative GnRH‐a | no estimate extracted | 1 study · 40 participants | Very low Downgraded: imprecision |
Postoperative use of LNG‐IUD compared to no postoperative treatment for symptomatic endometriosis following surgery
Population: Patients with symptomatic endometriosis following surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Painful symptoms Postoperative use of LNG‐IUD vs no postoperative treatment | RR 0.22 [0.08, 0.6] | 2 studies · 95 participants | Moderate Downgraded: risk of bias, imprecision |