Cochrane · systematic review · CD004832
Aspirin for in vitro fertilisation
Siristatidis, CS, Basios, G, Pergialiotis, V, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyLow‐dose aspirin compared to placebo or no treatment for women undergoing ART
Population: Women with subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Low‐dose aspirin vs placebo or no treatment | RR 0.91 [0.72, 1.15] | 3 studies · 1053 participants | Moderate Downgraded: imprecision |
Clinical pregnancy Low‐dose aspirin vs placebo or no treatment | RR 1.03 [0.91, 1.17] | 10 studies · 2142 participants | Moderate Downgraded: risk of bias |
Multiple pregnancy (on ultrasound) Low‐dose aspirin vs placebo or no treatment | RR 0.67 [0.37, 1.25] | 2 studies · 656 participants | Low Downgraded: imprecision |
Miscarriage rate per woman Low‐dose aspirin vs placebo or no treatment | RR 1.1 [0.68, 1.77] | 5 studies · 1497 participants | Low Downgraded: imprecision |
Ectopic pregnancy Low‐dose aspirin vs placebo or no treatment | RR 1.86 [0.75, 4.63] | 3 studies · 1135 participants | Very low Downgraded: risk of bias, imprecision |
Vaginal bleeding Low‐dose aspirin vs placebo or no treatment | RR 1.01 [0.14, 7.13] | 1 study · 487 participants | Very low Downgraded: risk of bias, imprecision |
Other adverse events Low‐dose aspirin vs placebo or no treatment | no estimate extracted | NR | No studies |
Comparison
Population: Patients with subfertile women undergoing ART
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per woman or couple | RR 0.91 | 3 studies · 1053 participants | Moderate Downgraded: risk of bias |
Clinical pregnancy rate per woman or couple1‐3 | RR 1.03 | 10 studies · 2142 participants | Low Downgraded: risk of bias |
Multiple pregnancy rate per woman per couple (on ultrasound) | no estimate extracted | 2 studies · 656 participants | Moderate Downgraded: risk of bias |
Multiple pregnancy rate per woman per couple at birth | RR 0.74 [0.38, 1.46] | 2 studies · 680 participants | Low Downgraded: risk of bias |
Complications during pregnancy per woman per couple ‐ ectopic pregnancy4 | RR 1.86 | 3 studies · 1135 participants | Low Downgraded: risk of bias |
Miscarriage rate per woman per couple | RR 1.1 | 5 studies · 1497 participants | Moderate Downgraded: risk of bias |