Cochrane · systematic review · CD003709

Vasopressors for hypotensive shock

Gamper, G, Havel, C, Arrich, J, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

Emergency and Critical Care2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 1 · 16.7%Moderate 1 · 16.7%High 2 · 33.3%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Dopamine compared with norepinephrine for hypotensive shock

Population: hypotensive shock

CD003709.PUB4 (current) · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Total mortalitya Dopamine vs norepinephrine	RR 1.07 [0.99, 1.16]	6 studies · 1400 participants	High
Arrhythmia < BR/> Dopamine vs norepinephrine	RR 2.33 [1.45, 3.85]	2 studies · 1931 participants	High

Terlipressin compared with norepinephrine for hypotensive shock

Population: hypotensive shock

CD003709.PUB4 (current) · 1 question

Outcome	Effect	Evidence	Status / GRADE
Total mortalitya Terlipressin vs norepinephrine	RR 0.93 [0.69, 1.26]	7 studies · 231 participants	Very low Downgraded: risk of bias, imprecision, indirectness

Vasopressin compared with norepinephrine for hypotensive shock

Population: hypotensive shock

CD003709.PUB4 (current) · 1 question

Outcome	Effect	Evidence	Status / GRADE
Total mortalitya Vasopressin vs norepinephrine	RR 0.9 [0.78, 1.03]	8 studies · 1108 participants	Moderate Downgraded: indirectness

Phenylephrine compared with norepinephrine for hypotensive shock

Population: hypotensive shock

CD003709.PUB4 (current) · 1 question

Outcome	Effect	Evidence	Status / GRADE
Total mortalitya Phenylephrine vs norepinephrine	RR 1.08 [0.76, 1.55]	2 studies · 86 participants	Very low Downgraded: risk of bias, imprecision, indirectness

Epinephrine compared with norepinephrine for hypotensive shock

Population: hypotensive shock

CD003709.PUB4 (current) · 1 question

Outcome	Effect	Evidence	Status / GRADE
Total mortalitya Epinephrine vs norepinephrine	RR 0.88 [0.63, 1.25]	1 study · 269 participants	Low

Norepinephrine compared to dopamine for hypotensive shock

Population: hypotensive shock

CD003709.PUB3 · 6 questions

Outcome	Effect	Evidence	Status / GRADE
Mortality Norepinephrine vs dopamine	RR 0.95 [0.87, 1.03]	6 studies · 1400 participants	High
Arrhythmia Norepinephrine vs dopamine	RR 0.43 [0.26, 0.69]	2 studies · 1931 participants	High
Length of stay in intensive care unit Days in ICU. Scale from: 5 to 6.8. Norepinephrine vs dopamine	no estimate extracted	2 studies · 1931 participants	High
Length of stay in hospital Days in hospital. Scale from: 11 to 14. Norepinephrine vs dopamine	no estimate extracted	2 studies · 1931 participants	High
Health related quality of life ‐ not reported Norepinephrine vs dopamine	no estimate extracted	NR	No studies
Anxiety and depression ‐ not reported Norepinephrine vs dopamine	no estimate extracted	NR	No studies