Cochrane · systematic review · CD003212
Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation
Lemyre, B, Deguise, M-O, Benson, P, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyNasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) to prevent extubation failure
Population: preterm neonates after extubation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Respiratory failure postextubation Nasal intermittent positive pressure ventilation (NIPPV) vs nasal continuous positive airway pressure (NCPAP) | RR 0.75 [0.67, 0.84] | 19 studies · 2738 participants | Moderate Downgraded: risk of bias |
Endotracheal reintubation Nasal intermittent positive pressure ventilation (NIPPV) vs nasal continuous positive airway pressure (NCPAP) | RR 0.78 [0.7, 0.87] | 17 studies · 2608 participants | Moderate Downgraded: risk of bias |
Gastrointestinal perforation Nasal intermittent positive pressure ventilation (NIPPV) vs nasal continuous positive airway pressure (NCPAP) | RR 0.89 [0.58, 1.38] | 8 studies · 1478 participants | Low Downgraded: risk of bias, imprecision |
Necrotising enterocolitis Nasal intermittent positive pressure ventilation (NIPPV) vs nasal continuous positive airway pressure (NCPAP) | RR 0.86 [0.65, 1.15] | 10 studies · 2069 participants | Moderate Downgraded: risk of bias |
Chronic lung disease (oxygen supplementation at 36 weeks) Nasal intermittent positive pressure ventilation (NIPPV) vs nasal continuous positive airway pressure (NCPAP) | RR 0.93 [0.84, 1.05] | 9 studies · 2001 participants | Moderate Downgraded: risk of bias |
Pulmonary air leak Nasal intermittent positive pressure ventilation (NIPPV) vs nasal continuous positive airway pressure (NCPAP) | RR 0.57 [0.37, 0.87] | 13 studies · 2404 participants | Low Downgraded: risk of bias, imprecision |
Mortality (defined as death before discharge) Nasal intermittent positive pressure ventilation (NIPPV) vs nasal continuous positive airway pressure (NCPAP) | RR 0.81 [0.61, 1.07] | 11 studies · 2258 participants | Low Downgraded: risk of bias, imprecision |
NIPPV versus NCPAP
Population: preterm neonates after extubation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Respiratory failure post extubation NIPPV vs NCPAP | RR 0.7 [0.6, 0.8] | 10 studies · 1431 participants | Moderate |
Endotracheal re‐intubation during the week post extubation NIPPV vs NCPAP | RR 0.76 [0.65, 0.88] | 8 studies · 1301 participants | Moderate |
Abdominal distension requiring cessation of feeds NIPPV vs NCPAP | RR 1.27 [0.64, 2.53] | 4 studies · 199 participants | Low |
Gastrointestinal perforation NIPPV vs NCPAP | RR 0.94 [0.6, 1.48] | 5 studies · 1066 participants | Moderate |
Necrotising enterocolitis NIPPV vs NCPAP | RR 0.87 [0.64, 1.19] | 6 studies · 1214 participants | Moderate |
Chronic lung disease (oxygen supplementation at 36 weeks) NIPPV vs NCPAP | RR 0.94 [0.8, 1.1] | 6 studies · 1140 participants | Moderate |
Pulmonary air leak NIPPV vs NCPAP | RR 0.48 [0.28, 0.82] | 6 studies · 1229 participants | Moderate |
Duration of hospitalisation (days) NIPPV vs NCPAP | no estimate extracted | 4 studies · 238 participants | Low |
Death before discharge NIPPV vs NCPAP | RR 0.69 [0.48, 0.99] | 6 studies · 1237 participants | Moderate |