Cochrane · systematic review · CD002118
Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology
Glujovsky, D, Quinteiro Retamar, AM, Alvarez Sedo, CR, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
8
No studies
1
Included studies
NR
No studies 1 · 11.1%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 55.6%Moderate 3 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyBlastocyst‐stage versus cleavage‐stage embryo transfer for assisted reproductive technology
Population: women and couples with subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes per couple Blastocyst‐stage vs cleavage‐stage embryo transfer | no estimate extracted | NR | No studies |
Live birth rate per fresh transfer Blastocyst‐stage vs cleavage‐stage embryo transfer | OR 1.27 [1.06, 1.51] | 15 studies · 2219 participants | Low Downgraded: risk of bias, imprecision |
Cumulative pregnancy rate (slow freezing) Blastocyst‐stage vs cleavage‐stage embryo transfer | OR 0.69 [0.48, 0.99] | 4 studies · 512 participants | Low Downgraded: risk of bias, imprecision |
Cumulative pregnancy rate (vitrification) Blastocyst‐stage vs cleavage‐stage embryo transfer | OR 2.44 [1.17, 5.12] | 1 study · 120 participants | Moderate Downgraded: risk of bias |
Clinical pregnancy rate Blastocyst‐stage vs cleavage‐stage embryo transfer | OR 1.25 [1.12, 1.39] | 32 studies · 5821 participants | Moderate Downgraded: risk of bias |
Multiple pregnancy rate Blastocyst‐stage vs cleavage‐stage embryo transfer | OR 1.12 [0.9, 1.38] | 22 studies · 4208 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Miscarriage rate Blastocyst‐stage vs cleavage‐stage embryo transfer | OR 1.24 [0.98, 1.57] | 21 studies · 4106 participants | Low Downgraded: risk of bias, imprecision |
Embryo freezing rate Blastocyst‐stage vs cleavage‐stage embryo transfer | OR 0.48 [0.4, 0.57] | 14 studies · 2292 participants | Low Downgraded: risk of bias, inconsistency |
Failure rate to transfer any embryos Blastocyst‐stage vs cleavage‐stage embryo transfer | OR 2.5 [1.76, 3.55] | 17 studies · 2577 participants | Moderate Downgraded: risk of bias |
Blastocyst stage versus cleavage stage embryo transfer for assisted reproductive technology
Population: Couples with subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes per couple Blastocyst stage vs cleavage stage embryo transfer | no estimate extracted | NR | No studies |
Live birth rate Blastocyst stage vs cleavage stage embryo transfer | OR 1.48 [1.2, 1.82] | 13 studies · 1630 participants | Low Downgraded: risk of bias |
Cumulative pregnancy rate Blastocyst stage vs cleavage stage embryo transfer | OR 0.89 [0.64, 1.22] | 5 studies · 632 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Clinical pregnancy rate Blastocyst stage vs cleavage stage embryo transfer | OR 1.3 [1.14, 1.47] | 27 studies · 4031 participants | Moderate Downgraded: risk of bias |
Multiple pregnancy rate Blastocyst stage vs cleavage stage embryo transfer | OR 1.05 [0.83, 1.33] | 19 studies · 3019 participants | Low Downgraded: risk of bias |
Miscarriage rate Blastocyst stage vs cleavage stage embryo transfer | OR 1.15 [0.88, 1.5] | 18 studies · 2917 participants | Low Downgraded: risk of bias, imprecision |
Embryo freezing rate Blastocyst stage vs cleavage stage embryo transfer | OR 0.48 [0.4, 0.57] | 14 studies · 2292 participants | Low Downgraded: risk of bias, inconsistency |
Failure rate to transfer any embryos Blastocyst stage vs cleavage stage embryo transfer | OR 2.5 [1.76, 3.55] | 17 studies · 2577 participants | Moderate Downgraded: risk of bias |