Cochrane · systematic review · CD001894

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI))

Lacey, L, Hassan, S, Franik, S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library

Gynaecology and Fertility2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 25%Low 3 · 75%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Assisted hatching compared to no assisted hatching for women undergoing assisted conception

Population: women undergoing assisted conception

CD001894.PUB6 (current) · 4 questions

Outcome	Effect	Evidence	Status / GRADE
Live births per woman randomised Assisted hatching vs no assisted hatching	OR 1.09 [0.92, 1.29]	14 studies · 2849 participants	Low Downgraded: risk of bias, publication bias
Multiple pregnancy rate per woman randomised Assisted hatching vs no assisted hatching	OR 1.38 [1.13, 1.68]	18 studies · 4308 participants	Low Downgraded: risk of bias, imprecision, inconsistency, publication bias
Clinical pregnancy rate per woman randomised Assisted hatching vs no assisted hatching	OR 1.2 [1.09, 1.33]	39 studies · 7249 participants	Low Downgraded: risk of bias, imprecision, inconsistency, publication bias
Miscarriage rate per woman randomised Assisted hatching vs no assisted hatching	OR 1.13 [0.82, 1.56]	17 studies · 2810 participants	Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias

Live birth

Population: Women undergoing assisted conception

CD001894.PUB5 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Live birth per woman randomised	OR 1.03 [0.85, 1.26]	9 studies · 1921 participants	Moderate Downgraded: risk of bias

Multiple pregnancy

Population: Women undergoing assisted reproduction

CD001894.PUB5 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Multiple pregnancy rate per woman randomised	OR 1.38 [1.11, 1.7]	14 studies · 3447 participants	Low Downgraded: risk of bias

Clinical pregnancy

Population: Women undergoing assisted reproduction

CD001894.PUB5 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Clinical pregnancy rate per woman randomised	OR 1.13 [1.01, 1.27]	31 studies · 5728 participants	Moderate Downgraded: risk of bias

Miscarriage

Population: Women undergoing assisted reproduction

CD001894.PUB5 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Miscarriage per woman randomised	OR 1.03 [0.69, 1.54]	14 studies · 2131 participants	Moderate Downgraded: risk of bias