Clobetasol propionate cream probably leads to higher disease control (healing of skin lesions) at day 21 compared with oral prednisone (moderate certainty).
Doxycycline probably leads to lower treatment‐related mortality at 1 year (mITT) compared with prednisolone (moderate certainty).
Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty).
It is very uncertain whether prednisone plus azathioprine changes disease control (at 6 months) compared with prednisone (very low certainty).
It is very uncertain whether prednisone plus azathioprine changes mortality (at 6 months) compared with prednisone (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether nicotinamide plus tetracycline changes disease control: complete response at 8 weeks: excluding dropouts compared with prednisone (very low certainty).
It is very uncertain whether nicotinamide plus tetracycline changes mortality at 6 months compared with prednisone (very low certainty).
The review found no eligible studies for this question.
Clobetasol propionate cream showed no clear difference in mortality at 1 year compared with oral prednisone (low certainty).
It is very uncertain whether methylprednisolone plus azathioprine changes mortality at 1 year compared with methylprednisolone plus dapsone (very low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Clobetasol propionate cream may leads to lower adverse events: severe complications at day 21 compared with oral prednisone (low certainty).
Mild clobetasol propionate cream regimen (10 to 30 g/day) showed no clear difference in disease control (healing of skin lesions) at day 21.… compared with standard clobetasol propionate cream regimen (40 g/day) (moderate certainty).