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What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 115 findings · 8 reviews

No studies found 27 · 23.5%GRADE not reported 63 · 54.8%Very low 14 · 12.2%Low 3 · 2.6%Moderate 8 · 7%High 0 · 0%

Fluoride varnish vs Fluoride toothpaste alone

Proportion of children developing new caries (deciduous) · Children and adolescents aged 16 years or less
1 finding from 1 review

Fluoride varnish vs placebo or no treatment

Proportion of children developing new caries (deciduous) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in proportion of children developing one or more new caries… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Fluoride varnish vs placebo or no treatment

Proportion of children developing new caries (permanent) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in proportion of children developing one or more new caries (permanent… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish

Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)

It is very uncertain whether resin-based fissure sealant plus fluoride varnish changes dentine caries in permanent molars (yes/no) compared with fluoride varnish alone (very low certainty).

1 finding from 1 review

Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations)

Caries arrest · Children and adults (with or without carious lesions)

Silver diamine fluoride (SDF) plus fluoride varnish showed no clear difference in caries arrest compared with sealants plus fluoride varnish (with or without restorations) (low certainty).

1 finding from 1 review

Fluoride varnish vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride toothpaste; GRADE not reported.

1 finding from 1 review

Fluoride varnish vs Fluoride mouthrinse

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride mouthrinse; GRADE not reported.

1 finding from 1 review