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What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 30%Low 1 · 10%Moderate 6 · 60%High 0 · 0%

Zonisamide vs placebo

50% responder rate · people with focal epilepsy

Zonisamide probably leads to higher 50% responder rate (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Withdrawal rates ‐ Any dose · people with focal epilepsy

Zonisamide probably leads to higher withdrawal rates (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Frequency of adverse effects ‐ dizziness ( · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: dizziness (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Adverse effect: fatigue · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: fatigue (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Nausea · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: nausea (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Somnolence · people with focal epilepsy

Zonisamide probably leads to higher adverse effects: somnolence (whole treatment period; any dose) compared with placebo (moderate certainty).

1 finding from 1 review

Zonisamide vs placebo

Functional abilities Change in TRS part B score (motor tasks) Change in TRS part C score (functional disability) (higher scores indicate a better outcome) · patients with essential tremor

It is very uncertain whether zonisamide changes functional abilities Change in TRS part B score (motor tasks) Change… compared with placebo (very low certainty).

1 finding from 1 review

Zonisamide vs placebo

Study Withdrawals · patients with essential tremor

It is very uncertain whether zonisamide changes study withdrawal for any reason Number of participants withdrawn… compared with placebo (very low certainty).

1 finding from 1 review

Zonisamide vs placebo

Adverse events Number of adverse events · patients with essential tremor

It is very uncertain whether zonisamide changes adverse events Number of adverse events compared with placebo (very low certainty).

1 finding from 1 review