What do systematic reviews say?

QoL of participants living with SCD and their caregivers · people with sickle cell disease

Adverse effects · people with sickle cell disease

Frequency of hospitalization · people with sickle cell disease

Frequency of sickle cell‐related complications: number of participants with completely healed leg ulcer ( · people with sickle cell disease

Haemoglobin status · people with sickle cell disease

Frequency of crisis · people with sickle cell disease

Severity of pain · people with sickle cell disease

BMD Z score (total hip/femoral neck) · children and adults with β‐thalassaemia major and low bone mass

BMD Z score (lumbar spine) · children and adults with β‐thalassaemia major and low bone mass

BMD Z score (wrist) · children and adults with β‐thalassaemia major and low bone mass

Incidence of fractures · children and adults with β‐thalassaemia major and low bone mass

Mobility · children and adults with β‐thalassaemia major and low bone mass

Quality of life · children and adults with β‐thalassaemia major and low bone mass

Adverse effects of treatment · children and adults with β‐thalassaemia major and low bone mass

Pulmonary exacerbations number of participants requiring IV antibiotics · children with cystic fibrosis

FEV1 % predicted · children with cystic fibrosis

Adverse events number of participants hospitalised during the trial · children with cystic fibrosis

Need for antibiotics days of antibiotic use · children with cystic fibrosis

QoL · children with cystic fibrosis

Sputum microbiology · children with cystic fibrosis