Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

40 questions · 40 findings · 8 reviews

No studies found 7 · 17.5%GRADE not reported 1 · 2.5%Very low 11 · 27.5%Low 12 · 30%Moderate 6 · 15%High 3 · 7.5%

Vitrectomy vs vitreous tap biopsy and antibiotic injection

Additional surgical procedure, including vitrectomy and cataract surgery. · people with endophthalmitis following intraocular surgery

Vitrectomy showed no clear difference in additional surgical procedure, including vitrectomy and cataract… compared with vitreous tap biopsy and antibiotic injection (low certainty).

1 finding from 1 review

Vitrectomy vs vitreous tap biopsy and antibiotic injection

Improvement in visual acuity at 3 months' · people with endophthalmitis following intraocular surgery

It is very uncertain whether vitrectomy changes proportion of people with a visual acuity improvement of 10 letters… compared with vitreous tap biopsy and antibiotic injection (very low certainty).

1 finding from 1 review

Vitrectomy vs observation

Closure of macular hole · participants with idiopathic macular hole

Vitrectomy leads to higher hole closure at 6‐12 months compared with observation (high certainty).

1 finding from 1 review

Vitrectomy vs observation

Adverse outcomes · participants with idiopathic macular hole

Vitrectomy led to lower adverse outcomes compared with observation; GRADE not reported.

1 finding from 1 review

Vitrectomy vs scleral buckling

Primary retinal reattachment at least 3 months after operation · people with simple rhegmatogenous retinal detachments

Pars plana vitrectomy (PPV) showed no clear difference in primary retinal reattachment at least 3 months after operation compared with scleral buckling (low certainty).

1 finding from 1 review

Vitrectomy vs scleral buckling

Final anatomical success at least 3 months after operation · people with simple rhegmatogenous retinal detachments

Pars plana vitrectomy (PPV) showed no clear difference in final anatomical success at least 3 months after operation compared with scleral buckling (low certainty).

1 finding from 1 review

Vitrectomy vs scleral buckling

Recurrence of retinal detachment at least 3 months after operation · people with simple rhegmatogenous retinal detachments

Pars plana vitrectomy (PPV) may leads to lower recurrence of retinal detachment at least 3 months after operation compared with scleral buckling (low certainty).

1 finding from 1 review

Vitrectomy vs scleral buckling

Quality of life (satisfaction with vision) at least 3 months after operation · people with simple rhegmatogenous retinal detachments

It is very uncertain whether pars plana vitrectomy (PPV) changes quality of life (satisfaction with vision) at least 3 months after… compared with scleral buckling (very low certainty).

1 finding from 1 review

Vitrectomy vs scleral buckling

Adverse effects (cataract development, choroidal detachment, new/iatrogenic breaks, postoperative proliferative vitreoretinopathy, postoperative increase in intraocular pressure, development of cystoid macular oedema, macular pucker, strabismus) a... · people with simple rhegmatogenous retinal detachments

Pars plana vitrectomy (PPV) may leads to higher adverse effects (cataract development, choroidal detachment,… compared with scleral buckling (low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor (anti‐VEGF) with or without pan‐retinal photocoagulation (PRP) vs PRP alone

Need for vitrectomy · proliferative diabetic retinopathy

Anti‐vascular endothelial growth factor (anti‐VEGF) with or without… may leads to lower need for vitrectomy compared with PRP alone (low certainty).

1 finding from 1 review