Vitamin D 100,000 IU/month vs 12,000 IU/month
Serum 25-hydroxyvitamin D level · people with sickle cell disease
1 finding from 1 review
- no estimate extracted1 study · 57 participantsLow
Findings
What do systematic reviews say?
63 questions · 65 findings · 7 reviews · Cystic Fibrosis and Genetic Disorders
No studies found 40 · 61.5%GRADE not reported 1 · 1.5%Very low 9 · 13.8%Low 11 · 16.9%Moderate 4 · 6.2%High 0 · 0%
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Frequency of pain crises in the · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of pain crisis compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.18 [0.64, 2.18]1 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Severity of pain (use of opioid analgesics) · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes severity of pain (use of opioid analgesics) compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.33 [0.4, 4.37]1 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
QoL of participants living with SCD and their caregivers · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Adverse effects · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes adverse effects compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.56 [0.31, 1]1 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Frequency of hospitalization · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).
1 finding from 1 review
- RR 2.661 study · 83 participantsVery low
Vitamin C 1400 mg plus vitamin E 800 mg vs placebo
Haemoglobin status · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
1 finding from 1 review
- no estimate extracted1 study · 83 participantsVery low
Summary of findings: fat‐soluble vitamin E vs control
Neuropathy due to vitamin E deficiency · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: fat‐soluble vitamin E vs control
Retinopathy due to vitamin E deficiency · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: fat‐soluble vitamin E vs control
Vitamin E total lipid ratio · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: fat‐soluble vitamin E vs control
Vitamin E levels in serum: umol/L · adults and children with cystic fibrosis
1 finding from 1 review
- no estimate extracted6 participantsGRADE not reported
Summary of findings: water‐soluble vitamin E vs control
Vitamin E total lipid ratio · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: water‐soluble vitamin E vs control
Vitamin E levels in serum: umol/L · adults and children with cystic fibrosis
Summary of findings: water‐soluble vitamin E may leads to higher vitamin E levels in serum: umol/L compared with control (low certainty).
1 finding from 1 review
- MD 19.74 [13.48, 26]1 study · 45 participantsLow
Summary of findings: water‐soluble vitamin E vs control
Neuropathy due to vitamin E deficiency · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: water‐soluble vitamin E vs control
Retinopathy due to vitamin E deficiency · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin K vs control
Time to cessation of bleeding · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Vitamin K vs control
BMD Z score (lumbar spine) · adults and children with cystic fibrosis
1 finding from 1 review
- no estimate extracted1 study · 38 participantsVery low
Vitamin K vs control
QoL · adults and children with cystic fibrosis
The review found no eligible studies for this question.
2 findings from 1 review
- no estimate extractedStudies not reportedNo studies found
- no estimate extractedStudies not reportedNo studies found
Vitamin K vs control
Adverse events · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found