Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 95 findings · 21 reviews

No studies found 8 · 8.4%GRADE not reported 5 · 5.3%Very low 26 · 27.4%Low 35 · 36.8%Moderate 19 · 20%High 2 · 2.1%

Cognitive‐behavioural intervention vs unspecific control

ADHD symptoms · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
2 findings from 1 review

Cognitive‐behavioural intervention vs unspecific control

ADHD symptoms: self‐reported Assessed by: various scales · adults with ADHD (available evidence for participants aged between 25 to 53 years old)
2 findings from 1 review

Augmentation of current antidepressant (various) with cariprazine (1 mg/d to 4.5 mg/d) vs augmentation of current antidepressant (various) with placebo

Dropouts ‐ Any dose · treatment‐resistant depression in adults

Augmentation of current antidepressant (various) with cariprazine (1… probably leads to higher dropouts ‐ any dose compared with augmentation of current antidepressant (various) with placebo (moderate certainty).

1 finding from 1 review

Augmentation of current antidepressant (various) with cariprazine (1 mg/d to 4.5 mg/d) vs augmentation of current antidepressant (various) with placebo

> 50% reduction in depressive symptoms · treatment‐resistant depression in adults

Augmentation of current antidepressant (various) with cariprazine (1… probably leads to higher response (≥ 50% improvement in MADRS score) ‐ any dose compared with augmentation of current antidepressant (various) with placebo (moderate certainty).

1 finding from 1 review