Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 68 findings · 8 reviews · Pregnancy and Childbirth

No studies found 15 · 22.1%GRADE not reported 3 · 4.4%Very low 11 · 16.2%Low 33 · 48.5%Moderate 6 · 8.8%High 0 · 0%

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review