Findings

What do systematic reviews say?

20 questions · 21 findings · 4 reviews

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No studies found 9 · 42.9%GRADE not reported 6 · 28.6%Very low 5 · 23.8%Low 1 · 4.8%Moderate 0 · 0%High 0 · 0%

Topical phenytoin vs hydrocolloid dressing

Time to complete healing · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs hydrocolloid dressing

The proportion of pressure ulcers healed · people with pressure ulcers

Topical phenytoin may leads to lower proportion of ulcers healed within trial period (eight weeks) compared with hydrocolloid dressing (low certainty).

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
RR 0.55 [0.33, 0.92]
1 study · 56 participants
Low

Topical phenytoin vs hydrocolloid dressing

Adverse events · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 84 participants
GRADE not reported

Topical phenytoin vs hydrocolloid dressing

Pain · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
GRADE not reported

Topical phenytoin vs triple antibiotic ointment

Time to complete healing · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs triple antibiotic ointment

The proportion of pressure ulcers healed · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs triple antibiotic ointment

Adverse events · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
GRADE not reported

Topical phenytoin vs triple antibiotic ointment

Pain · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
GRADE not reported

Topical phenytoin vs simple dressing

The proportion of pressure ulcers healed · people with pressure ulcers

It is very uncertain whether topical phenytoin group changes proportion of ulcers healed within trial period (eight weeks) compared with a simple dressing (very low certainty).

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
RR 1.33 [0.63, 2.78]
1 study · 55 participants
Very low

Topical phenytoin vs simple dressing

Adverse events · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 81 participants
GRADE not reported

Topical phenytoin vs simple dressing

Pain · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs simple dressing

Time to complete healing · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs saline dressing

Primary outcome: prevention of ulcer · ulceration and other skin changes caused by nerve damage in leprosy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs saline dressing

Ulcer healing · ulceration and other skin changes caused by nerve damage in leprosy

2 findings from 1 review

Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Very low
Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23 participants
Very low

Topical phenytoin vs saline dressing

Primary outcome 3: Adverse events · ulceration and other skin changes caused by nerve damage in leprosy

1 finding from 1 review

Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 123 participants
Very low

Topical phenytoin vs saline dressing

Secondary outcome: quality of life · ulceration and other skin changes caused by nerve damage in leprosy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs saline dressing

Secondary outcome: acceptability of treatment · ulceration and other skin changes caused by nerve damage in leprosy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs saline dressing

Cost of the intervention · ulceration and other skin changes caused by nerve damage in leprosy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical triamcinolone acetonide vs Phenytoin syrup mouthwash (30 mg in 5 mL)

Positive response (not defined) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Triamcinolone acetonide 0.1% ointment (topical) led to higher positive response (not defined) compared with phenytoin syrup mouthwash (30 mg in 5 mL); GRADE not reported.

1 finding from 1 review

Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
7 days
RR 1.63 [1.13, 2.34]
1 study · 60 participants
GRADE not reported

NMA evidence for individual network: proportion with complete healing ‐ interventions vs saline gauze

Phenytoin · people with pressure ulcers

It is very uncertain whether NMA evidence for individual network: proportion with complete… changes phenytoin compared with saline gauze (very low certainty).

1 finding from 1 review

Dressings and topical agents for treating pressure ulcers 2017 · Cochrane Headline outcomes only
RR 1.27 [0.58, 2.8]
Studies not reported
Very low