What do systematic reviews say?

Tissue adhesive vs tape

Tissue adhesive showed no clear difference in wound dehiscence compared with adhesive tape (low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 0.96 [0.06, 14.55]
  1 study · 50 participants
  Low

Tissue adhesive vs tape

Tissue adhesive showed no clear difference in wound infection compared with adhesive tape (low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 1.37 [0.39, 4.81]
  3 studies · 190 participants
  Low

High viscosity tissue adhesive vs tissue adhesives

It is very uncertain whether high viscosity tissue adhesive changes wound infection compared with low viscosity tissue adhesive (very low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 0.82 [0.16, 4.31]
  1 study · 148 participants
  Very low

High viscosity tissue adhesive vs tissue adhesives

It is very uncertain whether high viscosity tissue adhesive changes wound dehiscence compared with low viscosity tissue adhesive (very low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 3.74 [0.21, 67.93]
  1 study · 148 participants
  Very low

Tissue adhesive vs suture

Tissue adhesive may leads to higher wound dehiscence compared with sutures (low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 3.35 [1.53, 7.32]
  10 studies · 736 participants
  Low

Tissue adhesive vs suture

It is very uncertain whether tissue adhesive changes wound infection compared with sutures (very low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 1.72 [0.92, 3.16]
  10 studies · 744 participants
  Very low

Tissue adhesive vs staples

Tissue adhesive showed no clear difference in wound dehiscence compared with staples (low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 0.53 [0.05, 5.33]
  1 study · 37 participants
  Low

Tissue adhesive vs staples

It is very uncertain whether tissue adhesive changes wound infection compared with staples (very low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 1.39 [0.3, 6.54]
  3 studies · 250 participants
  Very low

Tissue adhesive vs other methods

Tissue adhesive showed no clear difference in wound dehiscence compared with other methods (low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 0.55 [0.13, 2.38]
  1 study · 209 participants
  Low

Tissue adhesive vs other methods

Tissue adhesive showed no clear difference in wound infection compared with other methods (low certainty).

• Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
  RR 0.41 [0.11, 1.6]
  1 study · 209 participants
  Low

Standard polyurethane plus tissue adhesive vs standard polyurethane

It is very uncertain whether standard polyurethane plus tissue adhesive changes arterial catheter failure assessed during catheter dwell compared with standard polyurethane (very low certainty).

• Dressings and securement devices to prevent complications for peripheral arterial catheters 2024 · Cochrane Headline outcomes only
  RR 0.44 [0.2, 0.98]
  2 studies · 165 participants
  Very low

Standard polyurethane plus tissue adhesive vs standard polyurethane

• Dressings and securement devices to prevent complications for peripheral arterial catheters 2024 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 165 participants
  Very low

Standard polyurethane plus tissue adhesive vs standard polyurethane

It is very uncertain whether standard polyurethane plus tissue adhesive changes dislodgement assessed during catheter dwell compared with standard polyurethane (very low certainty).

• Dressings and securement devices to prevent complications for peripheral arterial catheters 2024 · Cochrane Headline outcomes only
  RR 0.54 [0.03, 9.62]
  2 studies · 165 participants
  Very low

Standard polyurethane plus tissue adhesive vs standard polyurethane

It is very uncertain whether standard polyurethane plus tissue adhesive changes occlusion assessed during catheter dwell compared with standard polyurethane (very low certainty).

• Dressings and securement devices to prevent complications for peripheral arterial catheters 2024 · Cochrane Headline outcomes only
  RR 1.2 [0.37, 3.91]
  2 studies · 165 participants
  Very low

Standard polyurethane plus tissue adhesive vs standard polyurethane

It is very uncertain whether standard polyurethane plus tissue adhesive changes adverse events assessed during catheter dwell and on product removal compared with standard polyurethane (very low certainty).

• Dressings and securement devices to prevent complications for peripheral arterial catheters 2024 · Cochrane Headline outcomes only
  RR 0.89 [0.09, 8.33]
  2 studies · 165 participants
  Very low

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

• Adhesively bonded versus non‐bonded amalgam restorations for dental caries 2016 · Cochrane All outcomes

  Mean 24 months
  Marginal deterioration of the restoration and fracture of the remaining tooth tissue - Follow‐up: mean 24 months | Study population | Relative effect (95% CI): Not estimable | Number of participants (studies): 31 (1…
  1 study · 31 participants
  Low

Subcuticular sutures vs tissue adhesives

Subcuticular sutures showed no clear difference in surgical site infection Incidence of wound infection compared with tissue adhesives (moderate certainty).

• Subcuticular sutures for skin closure in non‐obstetric surgery 2020 · Cochrane Headline outcomes only
  RR 0.77 [0.41, 1.45]
  10 studies · 869 participants
  Moderate

Subcuticular sutures vs tissue adhesives

Subcuticular sutures showed no clear difference in wound complications Incidence of wound complications compared with tissue adhesives (low certainty).

• Subcuticular sutures for skin closure in non‐obstetric surgery 2020 · Cochrane Headline outcomes only
  RR 0.62 [0.35, 1.11]
  11 studies · 1058 participants
  Low

Subcuticular sutures vs tissue adhesives

Subcuticular sutures may leads to lower wound dehiscence Incidence of wound dehiscence compared with tissue adhesives (low certainty).

• Subcuticular sutures for skin closure in non‐obstetric surgery 2020 · Cochrane Headline outcomes only
  RR 0.23 [0.07, 0.74]
  11 studies · 1155 participants
  Low

Subcuticular sutures vs tissue adhesives

• Subcuticular sutures for skin closure in non‐obstetric surgery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 99 participants
  Low