Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Gynaecology and Fertility

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 0 · 0%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Thyroxine vs placebo or no treatment

Adverse events including maternal pregnancy complications, foetal complications and adverse effects of thyroxine · subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism

Thyroxine led to lower adverse events including maternal pregnancy complications, foetal… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 1 participants
GRADE not reported

Thyroxine vs placebo or no treatment

Live birth rate – euthyroid women with anti‐TPO antibodies · subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism

Thyroxine showed no clear difference in live birth rate – euthyroid women with anti‐TPO antibodies compared with placebo or no treatment (low certainty).

1 finding from 1 review

Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism 2019 · Cochrane Headline outcomes only
RR 1.04 [0.83, 1.29]
2 studies · 686 participants
Low

Thyroxine vs placebo or no treatment

Miscarriage – anti‐TPO antibodies · subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism

Thyroxine showed no clear difference in miscarriage – anti‐TPO antibodies compared with placebo or no treatment (low certainty).

1 finding from 1 review

Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism 2019 · Cochrane Headline outcomes only
RR 0.83 [0.47, 1.46]
2 studies · 686 participants
Low