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What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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- Surgically induced or chronic acid gastroesophageal reflux (experimental) vs Non-reflux control animals · Dental erosion, alveolar bone destruction and oral/pharyngeal lesions
  Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. 2020 All outcomes
  Experimental animal (rat) models
  Two rat-model studies found significantly higher rates of dental erosion, alveolar bone destruction and osteomyelitis (Higo) and shorter molar crown heights with dentin exposure, inflammatory infiltration and fibrosis…
  2 studies
  GRADE not reported

Surgically induced or chronic acid gastroesophageal reflux (experimental) vs Non-reflux control animals

Dental erosion, alveolar bone destruction and oral/pharyngeal lesions · Rat models with surgically induced or chronic acid gastroesophageal reflux

In experimental rat models, induced gastroesophageal reflux caused dental erosion, alveolar bone destruction and oral lesions compared with controls, supporting biological plausibility; evidence is ungraded animal research.

1 finding from 1 review

Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. 2020 All outcomes
Experimental animal (rat) models
Two rat-model studies found significantly higher rates of dental erosion, alveolar bone destruction and osteomyelitis (Higo) and shorter molar crown heights with dentin exposure, inflammatory infiltration and fibrosis…
2 studies
GRADE not reported

Perceived psychosocial stress vs No or lower perceived stress

GCF elastase activity and non-surgical periodontal treatment outcome (salivary cortisol, ICTP measured; no effect reported) · Adults with periodontitis needing non-surgical periodontal treatment

In one 6-month longitudinal study, patients under psychosocial stress had higher gingival crevicular fluid elastase and poorer outcomes after non-surgical periodontal therapy; not pooled (ungraded).

1 finding from 1 review

Social-Biological Interactions in Oral Disease: A 'Cells to Society' View. 2016 All outcomes
6-month follow-up · Adults with periodontitis needing non-surgical treatment, UK (Sheffield)
no estimate extracted
1 study · 45 participants
GRADE not reported