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Evidence found and GRADE certainty

12 questions · 13 findings · 4 reviews · Skin

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No studies found 6 · 46.2%GRADE not reported 0 · 0%Very low 1 · 7.7%Low 3 · 23.1%Moderate 3 · 23.1%High 0 · 0%

Mohs micrographic surgery vs surgical excision

Recurrence · adults with basal cell carcinoma of the skin

Mohs micrographic surgery showed no clear difference in recurrence at 3 years compared with surgical excision (low certainty).

2 findings from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Eating a normally varied diet · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Restoration of sexual activity · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Reduction in number of flares · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Reduction in severity of flares · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Neoadjuvant immunotherapy (high dose interferon) plus chemotherapy vs neoadjuvant chemotherapy

Overall response rate (ORR), · stage III and IV cutaneous melanoma

It is very uncertain whether neoadjuvant immunotherapy (high dose interferon) plus chemotherapy changes overall response rate (ORR), measured after 8 weeks of treatment and… compared with neoadjuvant chemotherapy (very low certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Adverse effects ‐ complication rate at 1 week after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in adverse effects ‐ complication rate at 1 week after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Adverse effects ‐ complication rate at 3 months after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in adverse effects ‐ complication rate at 3 months after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Recurrence after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in recurrence rate at 3 months after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review