Maternal red blood cell folate at or near term (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review
Serum folate at or near term · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review
Neural tube defects (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate leads to lower neural tube defects (All) compared with no intervention, placebo or other micronutrients without folate… (high certainty).
1 finding from 1 review
Miscarriage · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in miscarriage (All) compared with no intervention, placebo or other micronutrients without folate… (moderate certainty).
1 finding from 1 review
Cleft lip (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in cleft lip (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Cleft palate (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in cleft palate (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Congenital cardiovascular anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in congenital cardiovascular anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Other congenital anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
Supplementation with folate showed no clear difference in other congenital anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).
1 finding from 1 review
Neonatal mortality · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review
Maternal anaemia at or near term (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention
1 finding from 1 review
Intervention not reported
Folate concentration Serum folate levels, measured between 6 and 12 months after entry to the study · 117 children with homozygous sickle cell (SS) disease
1 finding from 1 review
Intervention not reported
Haemoglobin concentration Haematological analyses were performed in the 100/115 (87%) children in whom baseline (within 2 months of entry to study) and 1 year (between 10 and 14 months after entry) · 117 children with homozygous sickle cell (SS) disease
1 finding from 1 review
Intervention not reported
Outcomes1 · 117 children with homozygous sickle cell (SS) disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Adverse events ‐ acute splenic sequestration Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ acute splenic sequestration Clinical events… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ painful episodes Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ painful episodes Clinical events experienced by… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ minor Infections Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ minor Infections Clinical events experienced by… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ major infections Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ major infections Clinical events experienced by… (low certainty).
1 finding from 1 review
Intervention not reported
Adverse events ‐ dactylitis Clinical events experienced by children during the 1 year period commencing at entry to the trial · 117 children with homozygous sickle cell (SS) disease
The intervention showed no clear difference in adverse events ‐ dactylitis Clinical events experienced by children… (low certainty).
1 finding from 1 review